Effects of Glutamine on Intestinal Development of Meat Rabbits

GUO Zhiqiang, TANG Li, LI Congyan, XIE Xiaohong, REN Yongjun, KUANG Liangde, ZHENG Jie, LEI Min

doi:10.3969/j.issn.1006-267x.2017.09.014

Chinese Journal of Animal Nutrition >

2017 , Vol. 29 >Issue 9: 3132 - 3137

DOI: https://doi.org/10.3969/j.issn.1006-267x.2017.09.014

Molecular Nutrition

Effects of Glutamine on Intestinal Development of Meat Rabbits

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1. Sichuan Animal Science Academy, Chengdu 610066, China;
2. Animal Breeding and Genetics Key Laboratory of Sichuan Province, Chengdu 610066, China

Received date: 2017-02-15

Online published: 2017-09-08

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Abstract

This experiment was conducted to evaluate the effects of glutamine on intestinal development of meat rabbits. Three hundred and sixty 28-day-old weaned New Zealand meat rabbits were selected and randomly divided into 4 groups with 9 replicates per group and 10 meat rabbits (half male and half female) per replicate. Meat rabbits in the 4 groups were fed experimental diets supplemented with 0, 0.4%, 0.8% and 1.2% glutamine based on a basal diet, respectively. The experimental period was 4 weeks. The results showed that glutamine supplementation had no significant effects on stomach weight and cecum weight at 35, 42 and 56 days of age and small intestine length at 56 days of age for meat rabbits (P>0.05), but diet supplemented with 0.8% glutamine could significantly increase the small intestine weight at 35 and 42 days of age for meat rabbits (P<0.05). Diet supplemented with 0.8% and 1.2% glutamine could significantly elevate the duodenum and jejunum villus height at 35 and 42 days of age for meat rabbits (P<0.05), and diet supplemented with 0.8% glutamine could significantly elevate the ileum villus height at 35 and 42 days of age and duodenum and jejunum villus height at 56 days of age for meat rabbits (P<0.05). Diet supplemented with 0.8% glutamine could significantly reduce the duodenum and jejunum crypt depth at 35 and 42 days of age and ileum crypt depth at 35 days of age for meat rabbits (P<0.05). In conclusion, glutamine supplementation can improve the intestinal development of meat rabbits at 1 to 2 weeks post weaning. In this experiment condition, the suitable supplemental level of glutamine in the diet of meat rabbits is 0.8%.

Key words： glutamine; meat rabbits; intestinal development

Cite this article

GUO Zhiqiang, TANG Li, LI Congyan, XIE Xiaohong, REN Yongjun, KUANG Liangde, ZHENG Jie, LEI Min . Effects of Glutamine on Intestinal Development of Meat Rabbits[J]. Chinese Journal of Animal Nutrition, 2017 , 29(9) : 3132 -3137 . DOI: 10.3969/j.issn.1006-267x.2017.09.014

References

[1] 谷子林,秦应和,任克良,等.中国养兔学[M].北京:中国农业出版社,2013:268-431.

[2] 郭志强,李丛艳,谢晓红,等.断奶日龄对肉兔肠道发育的影响[J].动物营养学报,2016,28(1):102-108.

[3] 李雪,王小城,熊霞,等.谷氨酰胺对断奶仔猪肠黏膜更新的影响及其机制[J].动物营养学报,2016,28(12):3729-3374.

[4] 布拉斯,威斯曼.家兔营养[M].2版.北京:中国农业出版社,2015.

[5] WU G Y,KNABE D A.Free and protein-bound amino acids in sow's colostrum and milk[J].The Journal of Nutrition,1994,124(3):415-424.

[6] WU G Y.Intestinal mucosal amino acid catabolism[J].The Journal of Nutrition,1998,128(8):1249-1252.

[7] SON J,LYSSIOTIS C A,YING H Q,et al.Glutamine supports pancreatic cancer growth through a KRAS-reg-ulated metabolic pathway[J].Nature,2013,496(7443):101-105.

[8] WANG B,WU G Y,ZHOU Z G,et al.Glutamine and intestinal barrier function[J].Amino Acids,2015,47(10):2143-2154.

[9] CABRERA R A,USRY J L,ARRELLANO C,et al.Effects of creep feeding and supplemental glutamine or glutamine plus glutamate (aminogut) on pre-and post-weaning growth performance and intestinal health of piglets[J].Journal of Animal Science and Biotechnology,2013,4(1):29.

[10] 叶亚玲,王自蕊,游金明,等.丙氨酰-谷氨酰胺对断奶仔猪小肠黏膜固有层免疫球蛋白A浆细胞数量、分泌型免疫球蛋白A及黏膜中白细胞介素含量的影响[J].动物营养学报,2015,27(1):59-66.

[11] 路静,李文立,姜建阳,等.谷氨酰胺对肉鸡小肠组织结构和吸收能力的影响[J].动物营养学报,2012,24(2):291-300.

[12] 付朝晖,李福昌,李冰,等.饲粮谷氨酰胺添加水平对生长獭兔生长性能、氮代谢和空肠黏膜酶活性的影响[J].动物营养学报,2014,26(2):397-403.

[13] 高玉琪,任战军,胡志刚,等.日粮添加不同水平谷氨酰胺对幼龄獭兔免疫性能及回肠黏蛋白基因表达的影响[J].中国兽医学报,2016,36(4):655-660.

[14] SUN X,MCELORY A,WEBB K E,Jr,et al.Broiler performance and intestinal alterations when fed drug-free diets[J].Poultry Science,2005,84(8):1294-1302.

[15] BROSNAN J T,BROSNAN M E. Glutamate:a truly functional amino acid[J].Amino Acids,2013,45(3):413-418.

[16] 周联高,章世元,刘艳芬,等.谷氨酰胺对肉仔鸡生产性能及免疫机能的影响[J].动物营养学报,2008,20(3):305-310.

[17] SOLTAN M A.Influence of dietary glutamine supplementation on growth performance,small intestinal morphology,immune response and some blood parameters of broiler chickens[J].International Journal of Poultry Science,2009,8(1):60-68.

[18] NRC.Nutrient requirements of swine[S].10th ed.Washington,D.C.:National Academy Pres,1998.

[19] 刘玉洁,刘军花,许婷婷,等.谷氨酰胺对饲喂高精料奶山羊盲肠黏膜形态及炎症因子mRNA表达的影响[J].动物营养学报,2014,26(2):513-518.

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