Molecular Nutrition

Effects of Dietary α-Ketoglutarate and Allicin on Growing Development and Nutrient Apparent Digestibility of Growing Pigs

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  • 1. Key Lab Agro-Ecology Processing Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan Engineering & Research Center of Healthy Breeding Livestock & Poultry, Scientific Observational and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha 410125, China;
    2. University of Chinese Academy of Sciences, Beijing 100049, China;
    3. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China

Received date: 2017-02-16

  Online published: 2017-09-08

Abstract

This experiment was conducted to study the effects of dietary α-ketoglutarate (AKG) and allicin on growth performance, nutrient apparent digestibility, serum biochemical parameters and intestinal morphologic structure of growing pigs. Forty healthy crossbred (Duroc×Landrace×Large White) growing pigs with (30.64±1.35) kg were randomly divided into 5 groups with 8 replicates per group and 1 pig per replicate by similar body weight and gender ratio. Pigs in control group were fed a basal diet (without antibiotics), while pigs in the experimental groups were fed the basal diet supplemented with either 25 mg/kg antibiotics (group Ⅰ), or 1.0% AKG (group Ⅱ), or 0.5% allicin (group Ⅲ), or 1.0% AKG combined with 0.5% allicin (group Ⅳ). The experiment lasted for 21 days after 7 days for pre-feeding. The results showed as follows:1) compared with control group, the average daily gain of pigs in groups Ⅰ and Ⅳ was respectively improved by 10.80% and 9.91% without significant difference (P>0.05). 2) Compared with control group, the calcium (Ca) apparent digestibility in group Ⅱ was significantly improved (P<0.05), the apparent digestibility of crude protein (CP), Ca and phosphorus (P) in group Ⅳ was significantly increased (P<0.05). Compared with group Ⅰ, the P apparent digestibility in group Ⅳ was significantly increased (P<0.05). 3) Compared with control group, pigs in group Ⅱ had significantly improved serum immunoglobulin G (IgG) content (P<0.05), and the serum triglyceride content in group Ⅲ was significantly decreased (P<0.05); pigs in group Ⅳ had significantly lower serum contents of total cholesterol (TCHO) and TG (P<0.05), but had significantly higher serum activities of alkaline phosphatase (AKP), glutamic-oxalacetic transaminase (AST) and alanine aminotransferase (ALT) (P<0.05), and significantly higher serum contents of immunoglobulin A (IgA) and IgG (P<0.05). Compared with group Ⅰ, the serum contents of TCHO and TG in group Ⅳ were tend to be decreased (P>0.05), while the serum activities of AST and ALT in group Ⅳ were significantly increased (P<0.05). 4) Compared with control group, the villous height of ileum and the ratio of the villous height to crypt depth of ileum and jejunum in group Ⅳ were significantly improved (P<0.05). 5) Compared with control group, the amounts of goblet cells and lymphocytes in the ileum of group Ⅳ were increased significantly (P<0.05). The results suggest that dietary supplementation with 1.0% AKG and 0.5% allicin can ameliorate intestinal morphologic structure, increase the ability of nutrient digestibility and absorption such as CP, Ca and P, and promote intestinal health, thus improve growth performance of growing pigs.

Cite this article

LIU Shaojuan, CHEN Jiashun, KANG Baoju, JIANG Qian, HE Liuqin, WU Fei, HUANG Niu, LI Huan, YIN Yulong, YAO Kang . Effects of Dietary α-Ketoglutarate and Allicin on Growing Development and Nutrient Apparent Digestibility of Growing Pigs[J]. Chinese Journal of Animal Nutrition, 2017 , 29(9) : 3193 -3201 . DOI: 10.3969/j.issn.1006-267x.2017.09.022

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