Effects of Guanidine Acetic Acid on Growth Performance, Antioxidant Capacity and Glycometabolism Key Enzymes of Nursery Pigs

LI Jielei, HAO Yue, GU Xianhong

doi:10.3969/j.issn.1006-267x.2017.10.040

2017 , Vol. 29 >Issue 10: 3773 - 3780

DOI: https://doi.org/10.3969/j.issn.1006-267x.2017.10.040

Molecular Nutrition

Effects of Guanidine Acetic Acid on Growth Performance, Antioxidant Capacity and Glycometabolism Key Enzymes of Nursery Pigs

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State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received date: 2017-03-27

Online published: 2017-09-28

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Abstract

This experiment was conducted to investigate the effects of guanidine acetic acid on growth performance, antioxidant capacity and glycometabolism key enzymes of nursery pigs. Sixty four healthy "Duroc×Landrace×Yorkshire" hybrid piglets with body weight of (19.03±1.30) kg were randomly divided into two groups with four replicates per group and eight piglets per replicate. The piglets in control group were fed a basal diet, while the others in guanidine acetic acid group were fed the basal diet supplemented with 600 mg/kg guanidine acetic acid. The pretest lasted for 7 days, and the experiment lasted for 14 days. The results showed as follows:1) compared with control group, average daily gain of nursery pigs in guanidine acetic acid group was significantly increased (P<0.05), and the ratio of feed to gain was significantly decreased (P<0.05). There were no significant differences in final body weight and average daily feed intake between two groups (P>0.05). 2) The superoxide dismutase (SOD) inhibition rate, glutathione (GSH) content and total antioxidant capacity (T-AOC) in plasma of nursery pigs in guanidine acetic acid group were significantly higher than those in control group (P<0.05). There was no significant difference in the content of malondialdehyde (MDA) between two groups (P>0.05). 3) The activities of fructose-6-phosphate kinase (PFK), pyruvate kinase (PK), isocitrate dehydrogenase (IDH), malate dehydrogenase (MDH), nicotinamide adenine dinucleotide coenzyme Q reductase (NADH-CoQ) and creatine kinase (CK) in plasma of nursery pigs in guanidine acetic acid group were significantly higher than those in control group (P<0.01). Compared with control group, the activity of hexokinase (HK) in plasma in guanidine acetic acid group had a decrease trend (0.05 ≤ P < 0.10), and the activity of adenosine triphosphate (ATP) synthase (ATPase) in plasma in guanidine acetic acid group had an increase trend (0.05 ≤ P < 0.10). In conclusion, dietary guanidine acetic acid can improve the growth performance and antioxidant capacity, promote catabolism in vivo by increasing the activities of glycometabolism key enzymes (PFK, PK, IDH, MDH) and mitochondrial respiratory chain related enzymes (NADH-CoQ, ATPase), improve the body ATP level, and thus may promote the energy storage organizations (muscle and fat) synthesis.

Key words： guanidine acetic acid; nursery pigs; growth performance; antioxidant capacity; glycometabolism

Cite this article

LI Jielei, HAO Yue, GU Xianhong . Effects of Guanidine Acetic Acid on Growth Performance, Antioxidant Capacity and Glycometabolism Key Enzymes of Nursery Pigs[J]. Chinese Journal of Animal Nutrition, 2017 , 29(10) : 3773 -3780 . DOI: 10.3969/j.issn.1006-267x.2017.10.040

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