XU Qiaoyun, HU Liangyu, WANG Mengzhi . Metabolic Pathway and Turnover Mechanism of Methionine in Animals[J]. Chinese Journal of Animal Nutrition, 2017 , 29(11) : 3877 -3884 . DOI: 10.3969/j.issn.1006-267x.2017.11.006

[1] LU S C.S-Adenosylmethionine[J].The International Journal of Biochemistry & Cell Biology,2000,32(4):391-395.  

[2] ZEISEL S H.Choline:critical role during fetal development and dietary requirements in adults[J].Annual Review of Nutrition,2006,26(1):229-250.  

[3] 胡诚军,江青艳,孔祥峰.畜禽蛋氨酸代谢及其生理功能研究进展[J].饲料工业,2016,37(15):23-27.

[4] LEVINE R L,MOSKOVITZ J,STADTMAN E R.Oxidation of methionine in proteins:roles in antioxidant defense and cellular regulation[J].IUBMB Life,2000,50(4/5):301-307.

[5] LU S C,MATO J M.S-adenosylmethionine in liver health,injury,and cancer[J].Physiolo cal Reviews,2012,92(4):1515-1542.  

[6] WU G.Dietary requirements of synthesizable amino acids by animals:a paradigm shift in protein nutrition[J].Journal of Animal Science and Biotechnology,2014,5:34.

[7] KLEMESRUD M J, KLOPFENSTEIN T J, LEWIS A J. Metabolize methionine and lysine require ments of growing cattle[J].Journal Animal Science,2000,78(1):199-206.  

[8] NRC. Nutrient requirements of dairy cattle[S].Seventh Revised Edition.Washington,D.C.:The National Academies Press,2001.

[9] SAKI A A,NASERI HARSINI R,TABATABACI M M,et al.Estimates of methionine and sulfur amino acid requirements for laying hens using different models[J].Revista Brasileira De Ciência Avícola,2012,14(3):209-216

[10] BARTSOCAS C S,THIER S O,CRAWFORD J D.Transport of L-methionine in rat intestine and kidney[J].Pediatric Research,1974,8(6):673-678.  

[11] TAUTT J.Transport of methionine by normal and transformed rat embryo fibrobla[J]. Acta Biochimica Polonica,1982,29(3/4):213-218.

[12] PÉNZES L,SIMON G.Intestinal absorption and turnover of DL-methionine during reproduction in the rat[J].Journal of Physiological Anthropology,1968,18(3):288-296.

[13] BROSNAN J T,BROSNAN M E.The sulfur-containing amino acids:an overview[J].Journal of Nutrition,2006,136(6):1636S-1640S.

[14] LODISH H,BERK A J,ZIPURSKY S L,et al.The three roles of RNA in protein synt-hesis[M]//FREEMAN W H,et al.Laboratory notebook.New York:Molecular Cell Biology Press,2000.

[15] LIU S M,TAVENDALE M,BERMINGHAM E N,et al.The effects of parasite infection on methionine metabolism in sheep[J].Proceedings of the Australian Society of Animal Production,2002,24:133-136.

[16] CAREW L B,EVARTS K G,ALSTER F A.Growth and plasma thyroid hormone concentrations of chicks fed diets deficient in essential amino acids[J].Poultry Science,1997,76(10):1398-1404.  

[17] CAREW L B,MCMURTRY J P,ALSTER F A.Effects of methionine deficiencies on plasma levels of thyroid hormones, insulin-like growth factors Ⅰ and Ⅱ,liver and bady weights, and feed intake in growing chickens[J].Poultry Science,2003,82(12):1932-1938.  

[18] SCHICK B P.Synthesis of proteins from[35S]methionine by guinea pig megakaryoc ytes in vivo and time course of appearance of newly synthesized proteins in platelets[J].Blood,1990,76(5):887-891.

[19] MAAIKE A R,BARBARA S,SHAJI C,et al.Methionine transmethylation and transsulfuration in the piglet gastrointestinal tract[J].Proceedings of the National Academy of Science,2007,104(9):3408-3413.  

[20] GOULAS C,ZERVAS G,PAPADOPOULOS G.Effect of dietary animal fat and methionine on dairy ewes milk yield and milk composition[J].Animal Feed Science and Technology,2003,105(1/2/3/4):43-54.

[21] PREYNAT A,LAPIERRE H,THIVIERGE M C,et al.Effects of supplements of folic acid, vitamin B₁₂, and rumen protected methionine on whole body metabolism of methionine and glucose in lactating dairy cows[J].Journal Dairy Science,92:677-689.

[22] HEGEDVS M,FEKETE S,ANDRÁSOFSZKY E,et al.Effect of methionine and its derivatives on the weight gain and protein utilization of growing rats[J].Acta Veterinaria Hungarica,1998,46(4):421-429.

[23] IZUMI K,KIKUCHI C,OKAMOTO M.Effect of rumen protected methionine on lactation performance of dairy cows[J].Asian-Australasian Journal of Animal Science,2000,13(9):1235-1238.  

[24] LEE C,GIALLONGO F,HRISTOV A N,et al.Effect of dietary protein level and rumenprotected amino acid supplementation on amino acid utilization for milk protein in lactating dairy cows[J].Journal of Dairy Science,2015,98(3):1885-1902.  

[25] MOORE L D,LE T,FAN G.DNA methylation and its basic function[J].Neuropsychopharmacology Official Publication of the American College of Neuropsychopharmacology,2013,38(1):23-38.  

[26] FISCHLE W,WANG Y M,ALLIS C D.Histone and chromatin cross-talk[J].Current Opinion in Cell Biology,2003,15(2):172-183.  

[27] TURBERVILLE C,CRADDOCK V M.Methylation of nuclear proteins by dimethylnitrosamine and by methionine in the rat in vivo[J].Biochemical Journal,1971,124(4):725-739.  

[28] MATO J M,ALVAREZ L,ORTIZ P,et al.S-adenosylmethionine synthesis:molecular mechanisms and clinical implications[J].Pulmonary Pharmacology & Therapeutics,1997,73(3):265-280.  

[29] FRIEDEL H A,GOA K L,BENFIELD P.S-adenosyl-l-methionine.A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism[J].Drugs,1989,38(3):389-416.  

[30] POTTER J D.Methyl supply,methyl metabolizing enzymes and colorectal neoplasia[J].Journal of Nutrition,2002,132(8):2410-2412.

[31] PASCALE R M,SIMILE M M,MIGLIO M D,et al.Chemoprevention of hepatocarcinogenesis:S-adenosyl-L-methionine[J].Alcohol,2002,27(3):193-198.  

[32] KRAZ S,SENGUL T.Relationship between abdominal fat and methionine deficiency in broilers[J].Czech Journal of Animal Science 2005,50(8):362-368.

[33] ELSHORBAGY A K,VALDIVIA-GARCIA M, MATTOCKS D A,et al.Cysteine supplementation reverses methionine restriction effects on rat adiposity:significance of stearoylcoenzyme A desaturase[J].Journal of Lipid Research,2011,52(1):104-112.  

[34] WALDROUP P W,M A MOTL,F YAN,et al.Effects of betaine and choline on response to methionine supplementation to broiler diets formulated to industry standards[J].Journal of Applied Poultry Research,2006,15:58-71

[35] NICULESCU M D,ZEISEL S H.Diet,methyl donors and DNA methylation:interactions between dietary folate,methionine and choline[J].Journal of Nutrition,2002,132(8):2333S-2335S.

[36] THOMAS T,THOMAS T J.Polyamines in cell growth and cell death:molecular mechanisms and therapeutic applications[J].Cellular and Molecular Life Science,2001,58(2):244-58.  

[37] LANDAU G,BERCOVICH Z,PARK M H,et al.The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation[J].Journal of Biological Chemistry,2010,285(17):12474-12481.  

[38] MANDAL S,MANDAL A,JOHANSSON H E,et al.Depletion of cellular polyamines,spermidine and spermine,causes a total arrest in translation and growth in mammaliancells[J].Proceedings of the National Academy of Sciences of the United States of America,2013,110(6):2169-2174.  

[39] YATIN M.Polyamines in living organisms[J].Journal of Cell and Molecular Biology,2002,1:57-67.

[40] CAI J,MAO Z,HWANG J J,et al.Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells[J].Cancer Research,1998,58(7):1444-1450.

[41] FINKELSTEIN J D.Methionine metabolism in mammals[J].Journal of Nutritional Biochemistry,1990,1(5):228-237.  

[42] KRAMER D L,SUFRIN J R,PORTER C W.Relative effects of S-adenosylmethionine depletion on nucleic acid methylation and polyamine biosynthesis[J].Biochemical Journal,1987,247(2):259-265.  

[43] SZABÓ C.Hydrogen sulphide and its therapeutic potential[J].Nature Reviews Drug Discovery,2007,6(11):917-935.  

[44] LOWICKA E,BELTOWSKI J.Hydrogen sulfide (H₂S)-the third gas of interest for pharmacologists[J].Pharmacological Reports,2007,59(1):4-24.

[45] BENAVIDES G A,SQUADRITO G L,MILLS R W,et al.Hydrogen sulfide mediates the vasoactivity of garlic[J].Proceedings of the National Academy of Sciences of theUnited States of America,2007,104(46):17977-17982.  

[46] LU S C.Regulation of hepatic glutathione synthesis[J].Seminars in Liver Disease,1998,18(4):331-343.  

[48] GREK C L,ZHANG J,MANEVICH Y,et al.Causes and consequences of cysteine S-glutathionylation[J].Journal of Biological Chemistry,2013,288(37):26497-26504.  

[49] CASTELLANO R,PERRUCHOT M H,CONDE-AGUILERA J A,et al.A methionine deficient diet enhances adipose tissue lipid metabolism and alters anti-oxidant pathways in young growing pigs[J].PLoS One,2015,10(7):e0130514.

[50] RIEDIJK M A,STOLL B,CHACKO S,et al.Methionine transmethylation and transsulfuration in the piglet gastrointestinal tract[J].Proceedings of the National Academy of Sciences of the United States of America,2007,104(9):3408-3413.  

[51] KIM Y G,KIM S K,KWON J W,et al.Effects of cysteine on amino acid concentrations and transsulfuration enzyme activities in rat liver with protein-calorie malnutrition[J].Life Sciences,2003,72(10):1171-1181.