Molecular Nutrition

Application of Bacillus subtilis Spore Surface Display of Functional Heterologous Protein

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  • 1. College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China;
    2. Branch College of Animal Husbandry and Veterinar, Chengdu Vocational College of Agricultural Science and Technology, Chengdu 611130, China

Received date: 2017-04-19

  Online published: 2017-10-31

Abstract

Bacillus subtilis is an aerobic positive bacteria which is used as a probiotic for both human and animal. It can be induced to differentiate into the spore by unfavorable condition of circumstances. Because of the special structure and physiological characteristics of Bacillus subtilis spore, researchers found that the spore was the ideal vector of enzymes and antigens, and had been used the coat protein as a carrier, adsorption or covalent methods to display foreign proteins on the surface of the spore. Now, some enzymes, antigens and other functional proteins have successes to be displayed on the spore. The paper introduced the structure of Bacillus subtilis spore, the technology of spore surface display and its application.

Cite this article

FENG Jie, WANG Zhenhua, PAN Kangcheng . Application of Bacillus subtilis Spore Surface Display of Functional Heterologous Protein[J]. Chinese Journal of Animal Nutrition, 2017 , 29(11) : 3893 -3898 . DOI: 10.3969/j.issn.1006-267x.2017.11.008

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