Effects of Cysteamine on Serum Biochemical Indices and Liver Lipid Metabolism of Ningxiang Pigs

QIN Longshan, XING Yueteng, ZHANG Yang, CHEN Yuguang, SHU Xugang, LIU Xingliang, ZHANG Bin, WU Xin

doi:10.3969/j.issn.1006-267x.2017.11.019

Chinese Journal of Animal Nutrition >

2017 , Vol. 29 >Issue 11: 3987 - 3993

DOI: https://doi.org/10.3969/j.issn.1006-267x.2017.11.019

Molecular Nutrition

Effects of Cysteamine on Serum Biochemical Indices and Liver Lipid Metabolism of Ningxiang Pigs

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1. Hunan Co-Innovation Center of Safety Animal Production, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China;
2. Research Center of Healthy Breeding of Livestock and Poultry, Hunan Engineering and Research Center of Animal and Poultry Science, Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;
3. College of Animal Science and Technology, Zhongkai University of Agricultural and Engineering, Guangzhou 510225, China;
4. Ningxiang Animal Husbandry, Veterinary and Aquatic Products Bureau, Ningxiang 410600, China

Received date: 2017-04-14

Online published: 2017-10-31

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Abstract

This study was conducted to explore the effects of cysteamine (CS) on serum biochemical indices and lipid metabolism in liver of Ningxiang pigs. Thirty Ningxiang barrows with an average initial weight of 43 kg were randomly allocated into 2 groups (each group had 5 replicates with 3 pigs each). Pigs in the control group were fed a basal diet, and in the experimental group were fed the basal diet supplemented with 80 mg/kg CS. The trial lasted for 8 weeks. The results were showed as follows:1) compared with the control group, dietary supplementation with CS increased serum contents of glucose, low density lipoprotein and total cholesterol by 21.91% (P<0.01), 26.22% (P<0.01) and 9.75% (P<0.10), but significantly decreased serum urea nitrogen content by 14.14% (P<0.05). 2) Compared with the control group, dietary supplementation with CS significantly decreased the contents of saturated fatty acids such as C14:0, C16:0 and C20:0 by 72.09% (P<0.01), 13.12% (P<0.05) and 71.13% (P<0.01), but increased C17:0 content by 11.77% (P<0.10); and increased the monounsaturated fatty acid content by 40.37% (P<0.01) in which C18:1n9c content was increased by 55.80% (P<0.01), but C18:1n9t content was decreased by 85.90% (P<0.01); while decreased the polyunsaturated fatty acid content by 7.56% (P<0.05) in which C18:2n6c content was decreased by 18.56% (P<0.01), while contents of C22:6n3 (DHA) and C20:3n6 were increased by 96.13% and 37.99% (P<0.01) in liver. 3) Compared with the control group, dietary supplementation with CS significantly raised the gene expression level of peroxisome proliferator-activated receptor-α (PPARα) (P<0.05). It is concluded that diet supplementation with CS can increase the DHA content in liver, which may be related to the regulation of the expression of PPARα in liver tissue, and then affects the liver lipid metabolism.

Key words： cysteamine; Ningxiang pig; serum biochemical indices; fatty acid composition; lipid metabolism

Cite this article

QIN Longshan, XING Yueteng, ZHANG Yang, CHEN Yuguang, SHU Xugang, LIU Xingliang, ZHANG Bin, WU Xin . Effects of Cysteamine on Serum Biochemical Indices and Liver Lipid Metabolism of Ningxiang Pigs[J]. Chinese Journal of Animal Nutrition, 2017 , 29(11) : 3987 -3993 . DOI: 10.3969/j.issn.1006-267x.2017.11.019

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