Regulatory Effects of Adenosine Monophosphate-Activated Protein Kinase on Glucose and Lipid Metabolism in Animals

GAO Xiaona, GUO Xiaoquan

doi:10.3969/j.issn.1006-267x.2017.12.007

Chinese Journal of Animal Nutrition >

2017 , Vol. 29 >Issue 12: 4287 - 4294

DOI: https://doi.org/10.3969/j.issn.1006-267x.2017.12.007

Molecular Nutrition

Regulatory Effects of Adenosine Monophosphate-Activated Protein Kinase on Glucose and Lipid Metabolism in Animals

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College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China

Received date: 2017-05-17

Online published: 2017-12-04

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Abstract

The adenosine monophosphate-activated protein kinase (AMPK) is found in all eukaryotic cells. AMPK activity is a response to adenosine monophosphate (AMP)/adenosine triphosphate (ATP). When a stress causes an inhibition of ATP production or an increase of ATP consumption, cellular AMP/ATP increases, AMPK is activated. Once activated AMPK can phosphorylates its downstream target proteins. As a result, the lipid and carbohydrate metabolisms are changed towards the switches on promoting ATP-producing and inhibiting ATP-consumption pathways, such as inhibitions of fatty acid and glycogen synthesis, stimulations of fatty acid oxidation and glucose absorption, by which energy in cells are rapidly recovered. Thus AMPK is called regulator of cell energy, and plays an important role for animals to adapt to the environment. This review summarized the structure, distribution, activity regulation and the regulatory roles on the glucose and lipid metabolism of AMPK based on the previous studies at home and abroad.

Key words： AMPK; animal; glucose metabolism; lipid metabolism

Cite this article

GAO Xiaona, GUO Xiaoquan . Regulatory Effects of Adenosine Monophosphate-Activated Protein Kinase on Glucose and Lipid Metabolism in Animals[J]. Chinese Journal of Animal Nutrition, 2017 , 29(12) : 4287 -4294 . DOI: 10.3969/j.issn.1006-267x.2017.12.007

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