This experiment was conducted to study the effects of dietary copper addition on performance, serum biochemical indices and serum enzymatic activities of weaning to 2-month-old long hairy rabbits. One hundred and eighty weaning Mengyin fine wool type long hairy rabbits were randomly assigned to 6 groups with 30 rabbits in each group, and the rabbits were feed separately. Rabbits in 6 groups were fed experimental diets which supplemented with 0, 10, 20, 40, 80 and 160 mg/kg copper (the form was CuSO₄·5H₂O) based on a basal diet, and the measured values of the copper in them were 3.25, 13.13, 23.40, 43.56, 83.58 and 163.87 mg/kg, respectively. The trail lasted for 7 days for adaption, and 23 days for test. The results showed as follows:dietary copper addition had extremely significant effects on average daily gain (ADG) and feed/gain (F/G) (P<0.01), and the highest value of ADG and lowest value of F/G were found when copper addition was 80 mg/kg. Dietary copper addition had no significant effects on lanugo production, wool diameter and fur area (P>0.05). Dietary copper addition had significant effects on the contents of total protein (TP), albumin (ALB), globulin (GLB) and urea nitrogen (UN), albumin/globulin (A/G) in serum (P<0.05). The serum UN content was firstly decreased and then increased with dietary copper addition increasing, and its lowest value was found when copper addition was 80 mg/kg. Dietary copper addition had no significant effect on serum copper-zinc superoxide dismutase (Cu-Zn SOD) activity (P>0.05), but it had significant effect on serum ceruloplasmin activity (P<0.05). The serum ceruloplasmin activity was firstly increased and then decreased with dietary copper addition increasing, and its highest value was found when copper addition was 80 mg/kg. Dietary copper addition had significant effect on liver index (P<0.05), but it had no significant effects on other organ indices (P>0.05). When copper addition was 80 mg/kg, the liver index had the highest value. Considering all indices of this experiment, the appropriate copper addition is 20 to 80 mg/kg for weaning to 2-month-old long hairy rabbits.