Molecular Nutrition

Intestinal Epithelium Major Glucose Transporters and Their Action Mechanisms

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  • College of Animal Science and Technology, Southwest University, Beibei 400715, China

Received date: 2017-06-27

  Online published: 2018-01-04

Abstract

Glucose is primarily absorbed via sodium dependent glucose transporter 1 (SGLT1) and facilitative glucose transporter 2 (GLUT2) in intestinal epithelia. Many factors involved in the glucose absorption in the gut are acted by regulation of SGLT1 and GLUT2 at the transcription level, mRNA stability and protein level. Through the studies on structures and functions of those glucose transporters, not only for human relative disease including obesity and diabetes to provide potential drug target, but also can provide ideas for controlling animal nutrition absorption. This review summarized glucose transporters SGLT1 and GLU2, their functions and factors affecting their expression, and conducted to elucidate the process of glucose absorption in intestine and regulation of glucose homeostasis at the molecular level.

Cite this article

LU Yao, SUN Peipei, SONG Daijun . Intestinal Epithelium Major Glucose Transporters and Their Action Mechanisms[J]. Chinese Journal of Animal Nutrition, 2018 , 30(1) : 50 -58 . DOI: 10.3969/j.issn.1006-267x.2018.01.008

References

[1] FENG L,FROMMER W B.Structure and function of semisweet and sweet sugar transporters[J].Trends in Biochemical Sciences,2015,40(8):480-486.  

[2] CHEN L Q,CHEUNG L S,FENG L,et al.Transport of sugars[J].Annual Review of Biochemistry,2015,84(1):865-894.  

[3] MUECKLER M,THORENS B.The SLC2(GLUT) family of membrane transporters[J].Molecular Aspects of Medicine,2013,34(2/3):121-138.

[4] WRIGHT E M,LOO D D,HIRAYAMA B A.Biology of human sodium glucose transporters[J].Physiological Reviews,2011,91(2):733-794.  

[5] FAHAM S,WATANABE A,BESSERER G M,et al.The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+/sugar symport[J].Science,2008,321(5890):810-814.  

[6] SALA-RABANAL M,HIRAYAMA B A,LOO D D,et al.Bridging the gap between structure and kinetics of human SGLT1[J].American Journal of Physiology Cell Physiology,2012,302(9):C1293-C1305.

[7] YANG C B,ALBIN D M,WANG Z R,et al.Apical Na+-D-glucose cotransporter 1(SGLT1) activity and protein abundance are expressed along the jejunal crypt-villus axis in the neonatal pig[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2010,300(1):G60-G70.

[8] EROKHOVA L,HORNER A,OLLINGER N,et al.The sodium glucose cotransporter SGLT1 is an extremely efficient facilitator of passive water transport[J].Journal of Biological Chemistry,2016,291(18):9712-9720.  

[9] SUN L F,ZENG X,YAN C Y,et al.Crystal Structure of a bacterial homologue of glucose transporters GLUT1-4[J].Nature,2012,490(7420):361-366.  

[10] THORENS B.GLUT2,glucose sensing and glucose homeostasis[J].Diabetologia,2015,58(2):221-232.  

[11] CORPE C P,ECK P,WANG J,et al.Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters,GLUT2 and GLUT8[J].Journal of Biological Chemistry,2013,288(13):9092-9101.  

[12] CHEN L H,TUO B G,DONG H.Regulation of intestinal glucose absorption by ion channels and transporters[J].Nutrients,2016,8(1):43-53.  

[13] RÖDER P V,GEILLINGER K E,ZIETEK T S,et al.The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing[J].Plos One,2014,9(2):e89977.

[14] KUHRE R E,FROST C R,SVENDSEN B,et al.Molecular mechanisms of glucose-stimulated GLP-1 secretion from perfused rat small intestine[J].Diabetes,2015,64(2):370-382.  

[15] MARGOLSKEE R F,DYERJ,KOKRASHVILI Z,et al.T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1[J].Proceedings of the National Academy of Sciences of the United States of America,2007,104(38):15075-15080.  

[16] KUHRE R E,BECHMANN L E,ALBRECHTSEN N J W,et al.Glucose stimulates neurotensin secretion from the rat small intestine by mechanisms involving SGLT1 and GLUT2,leading to cell depolarization and calcium influx[J].American Journal of Physiology:Endocrinology and Metabolism,2015,308(12):E1123-E1130.

[17] EGEROD K L,ENGELSTOFT M S,GRUNDDAL K V,et al.A major lineage of enteroendocrine cells coexpress CCK,secretin,GIP,GLP-1,PYY,and neurotensin but not somatostatin[J].Endocrinology,2012,153(12):5782-5795.  

[18] YAN N.Structural advances for the major facilitator superfamily (MFS) transporters[J].Trends in Biochemical Sciences,2013,38(3):151-159.  

[19] AFFLECK J A,HELLIWELL P A,KELLETT G L.Immunocytochemical detection of GLUT2 at the rat intestinal brush-border membrane[J].Journal of Histochemistry & Cytochemistry,2003,51(11):1567-1574.  

[20] KELLETT G L,BROT-LAROCHE E,MACE O J,et al.Sugar absorption in the intestine:the role of GLUT2[J].Annual Review of Nutrition,2008,28(1):35-54.  

[21] MORAN A W,AL-RAMMAHI M A,ARORA D K,et al.Expression of Na+/glucose co-transporter 1(SGLT1) in the intestine of piglets weaned to different concentrations of dietary carbohydrate[J].British Journal of Nutrition,2010,104(5):647-655.  

[22] COHEN M,KITSBERG D,TSYTKIN S,et al.Live imaging of GLUT2 glucose-dependent trafficking and its inhibition in polarized epithelial cysts[J].Open Biology,2014,4(7):140091.

[23] HELLIWELL P A,RUMSBY M G,KELLETT G L.Intestinal sugar absorption is regulated by phosphorylation and turnover of protein kinase C βⅡ mediated by phosphatidylinositol 3-kinase-and mammalian target of rapamycin-dependent pathways[J].Journal of Biological Chemistry,2003,278(31):28644-28650.  

[24] SHIRAZI-BEECHEY S P,MORAN A W,BATCHELOR D J,et al.Glucose sensing and signalling; regulation of intestinal glucose transport[J].Proceedings of the Nutrition Society,2011,70(2):185-193.  

[25] LOFLIN P,LEVER J E.Hur binds a cyclic nucleotide-dependent,stabilizing domain in the 3' untranslated region of Na+/glucose cotransporter (SGLT1) mRNA[J].FEBS Letters,2001,509(2):267-271.  

[26] INOUE S,HONMA K,MOCHIZUKI K,et al.Induction of histone H3K4 methylation at the promoter,enhancer,and transcribed regions of the Si and SGLT1 genes in rat jejunum in response to a high-starch/low-fat diet[J].Nutrition,2015,31(2):366-372.  

[27] CHINTALAPATI C,KELLER T,MUELLER T D,et al.Protein Rs1(RSC1A1) downregulates the exocytotic pathway of glucose transporter SGLT1 at low intracellular glucose via inhibition of ornithine decarboxylase[J].Molecular Pharmacology,2016,90(5):508-521.  

[28] MARTÍN M G,WANG J,SOLORZANO-VARGAS R S,et al.Regulation of the human Na+-glucose cotransporter gene,SGLT1,by HNF-1 and Sp1[J].American Journal of Physiology Gastrointestinal & Liver Physiology,2000,278(4):G591-G603.

[29] LEE H M,LEE O H,KIM K J,et al.Ginsenoside Rg1 promotes glucose uptake through activated AMPK pathway in insulin-resistant muscle cells[J].Phytotherapy Research,2012,26(7):1017-1022.  

[30] WANG C W,CHANG W L,HUANG Y C,et al.An essential role of camp response element-binding protein in epidermal growth factor-mediated induction of sodium/glucose cotransporter 1 gene expression and intestinal glucose uptake[J].The International Journal of Biochemistry & Cell Biology,2015,64:239-251.

[31] LANE R H,DVORAK B,MACLENNAN N K,et al.IGF alters jejunal glucose transporter expression and serum glucose levels in immature rats[J].American Journal of Physiology:Regulatory Integrative and Comparative Physiology,2002,283(6):R1450-R1460.

[32] JANKU F,HUANG H J,ANGELO L S,et al.A kinase-independent biological activity for insulin growth factor-1 receptor (IGF-1R):implications for inhibition of the IGF-1R signal[J].Oncotarget,2013,4(3):463-473.  

[33] BLANCO A M,BERTUCCI J I,RAMESH N,et al.Ghrelin facilitates GLUT2-,SGLT1-and SGLT2-mediated intestinal glucose transport in goldfish (Carassius Auratus)[J].Scientific Reports,2017,7:45024.

[34] CASSELBRANT A,MALINAUSKAS M,MARSCHALL H U,et al.Angiotensin Ⅱ exerts dual actions on sodium-glucose transporter Ⅰ-mediated transport in the human jejunal mucosa[J].Scandinavian Journal of Gastroenterology,2015,50(9):1068-1075.  

[35] LI Z W,SUN F,ZHANG Y H,et al.Tacrolimus induces insulin resistance and increases the glucose absorption in the jejunum:a potential mechanism of the diabetogenic effects[J].PLoS One,2015,10(11):e0143405.

[36] MATOSIN-MATEKALO M,MESONERO J E,DELEZAY O,et al.Thyroid hormone regulation of the Na+/glucose cotransporter SGLT1 in Caco-2 cells[J].Biochemical Journal,1998,334(3):633-640.  

[37] 吴疑,匡梅,周红,等.TLR4信号通路及其负调控研究进展[J].现代医药卫生,2016,32(18):2821-2824.

[38] BARRENETXE J,SÁNCHEZ O,BARBER A,et al.TNFα regulates sugar transporters in the human intestinal epithelial cell line Caco-2[J].Cytokine,2013,64(1):181-187.  

[39] KEKUDA R,SAHA P,SUNDARAM U.Role of Sp1 and HNF1 transcription factors in SGLT1 regulation during chronic intestinal inflammation[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2008,294(6):G1354-G1361.

[40] BOUDRY G,CHEESEMAN C I,PERDUE M H.Psychological stress impairs Na+-dependent glucose absorption and increases GLUT2 expression in the rat jejunal brush-border membrane[J].American Journal of Physiology:Regulatory,Integrative and Comparative Physiology,2006,292(2):R862-R867.

[41] LI Y,CAI H Y,LIU G H,et al.Effects of stress simulated by dexamethasone on jejunal glucose transport in broilers[J].Poultry Science,2009,88(2):330-337.  

[42] SHEPHERD E J,HELLIWELL P A,MACE O J,et al.Stress and glucocorticoid inhibit apical GLUT2-trafficking and intestinal glucose absorption in rat small intestine[J].Journal of Physiology,2004,560(1):281-290.  

[43] CERVANTES M,COTA M,ARCE N,et al.Effect of heat stress on performance and expression of selected amino acid and glucose transporters,Hsp90,leptin and ghrelin in growing pigs[J].Journal of Thermal Biology,2016,59:69-76.

[44] EBRAHIMI R,JAHROMI M F,LIANG J B,et al.Effect of dietary lead on intestinal nutrient transporters MRNA expression in broiler chickens[J].Biomed Research International,2015,2015:149745.

[45] REICHARDT S D,FÖLLER M,REXHEPAJ R,et al.Glucocorticoids enhance intestinal glucose uptake via the dimerized glucocorticoid receptor in enterocytes[J].Endocrinology,2012,153(4):1783-1794.  

[46] GRAHAMMER F,HENKE G,SANDU C,et al.Intestinal function of gene-targeted mice lacking serum-and glucocorticoid-inducible kinase[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2006,290(6):1114-1123.  

[47] ASANUMA-DATE K,HIRANO Y,LE N,et al.Functional regulation of sugar assimilation by N-glycan-specific interaction of pancreatic α-amylase with glycoproteins of duodenal brush border membrane[J].Journal of Biological Chemistry,2012,287(27):23104-23118.  

[48] DATE K,SATOH A,ⅡDA K,et al.Pancreatic α-amylase controls glucose assimilation by duodenal retrieval through N-glycan-specific binding,endocytosis,and degradation[J].Journal of Biological Chemistry,2015,290(28):17439-17450.  

[49] KANE S,SEATTER M J,GOULD G W.Functional studies of human GLUT5:effect of pH on substrate selection and an analysis of substrate interactions[J].Biochemical and Biophysical Research Communications,1997,238(2):503-505.  

[50] DIAO H,YAN H L,XIAO Y,et al.Intestinal microbiota could transfer host gut characteristics from pigs to mice[J].BMC Microbiology,2016,16(1):238.

[51] FATIMA J,IQBAL C W,HOUGHTON S G,et al.Hexose transporter expression and function in mouse small intestine:role of diurnal rhythm[J].Journal of Gastrointestinal Surgery,2009,13(4):634-641.  

[52] BALAKRISHNAN A,STEARNS A T,ASHLEY S W,et al.Per1 modulates SGLT1 transcription in vitro independent of E-Box status[J].Digestive Diseases and Sciences,2012,57(6):1525-1536.  

[53] CAVIN J B,COUVELARD A,LEBTAHI R,et al.Differences in alimentary glucose absorption and intestinal disposal of blood glucose after roux-En-Y gastric bypass vs sleeve gastrectomy[J].Gastroenterology,2016,150(2):454-464.e9.  

[54] WANG Y M,ZHANG X,LIU T,et al.Jejunum-ileum circuit procedure improves glucose metabolism in diabetic rats independent of weight loss[J].Obesity,2016,24(2):342-351.  

[55] KHACHAB M,KANAAN A,AWAD D,et al.Colectomy induces an aldosterone-mediated increase in jejunal glucose uptake in rats[J].Life Sciences,2017,174:43-49.

[56] YALCIN S,GURSEL I,BILGEN G,et al.Effect of egg storage duration and brooding temperatures on chick growth,intestine morphology and nutrient transporters[J].Animal:An International Journal of Animal Bioscience,2017, 11(10):1791-1797.  
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