Epigenetic Mechanisms of Lipopolysaccharide-Induced Inflammation and Their Nutritional Manipulations

CHEN Jingbo, DONG Guozhong, SUN Yawang, ZHANG Zhu

doi:10.3969/j.issn.1006-267x.2018.01.009

Chinese Journal of Animal Nutrition >

2018 , Vol. 30 >Issue 1: 59 - 65

DOI: https://doi.org/10.3969/j.issn.1006-267x.2018.01.009

Molecular Nutrition

Epigenetic Mechanisms of Lipopolysaccharide-Induced Inflammation and Their Nutritional Manipulations

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Chongqing Key Laboratory of Forage and Herbivores, College of Animal Science and Technology, Southwest University, Chongqing 400716, China

Received date: 2017-06-14

Online published: 2018-01-04

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Abstract

In practical animal production, lipopolysaccharide widely exists in air, drinking water, feed and feces. In addition, heat stress and the feeding of high concentrate diets also lead to release of more lipopolysaccharide in digestive tract. When lipopolysaccharide enters the body, it can cause inflammation. Studying molecular mechanisms and manipulative avenues of lipopolysaccharide-induced inflammation is of great significance for improving animal health and production performance. From an epigenetic point of view, mechanisms of inflammation may be better understood at the molecular level. Moreover, there is a close relationship between nutritional factors and epigenetic alterations. This article reviewed the epigenetic mechanisms of lipopolysaccharide-induced inflammation and their nutritional manipulations.

Key words： lipopolysaccharide; inflammation; epigenetics; mechanism; nutritional manipulation

Cite this article

CHEN Jingbo, DONG Guozhong, SUN Yawang, ZHANG Zhu . Epigenetic Mechanisms of Lipopolysaccharide-Induced Inflammation and Their Nutritional Manipulations[J]. Chinese Journal of Animal Nutrition, 2018 , 30(1) : 59 -65 . DOI: 10.3969/j.issn.1006-267x.2018.01.009

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