[1] ZASLOFF M.Antimicrobial peptides of multicellular organisms[J].Nature,2002,415(6870):389-395.
[2] LAI Y P,GALLO R L.AMPed up immunity:how antimicrobial peptides have multiple roles in immune defense[J].Trends in Immunology,2009,30(3):131-141.
[3] NGUYEN L T,HANEY E F,VOGEL H J.The expanding scope of antimicrobial peptide structures and their modes of action[J].Trends in Biotechnoloy,2011,29(9):464-472.
[4] ZHANG L J,GALLO R L.Antimicrobial peptides[J].Current Biology,2016,26:R14-R19.
[5] BALTZER S A,BROWN M H.Antimicrobial peptides-promising alternatives to conventional antibiotics[J].Journal of Molecular Microbiology and Biotechnology,2011,20(4):228-235.
[6] MANSOUR S C,PENA O M,HANCOCK R E W.Host defense peptides:front-line immunomodulators[J].Trends Immunology,2014,35(9):443-450.
[7] FRITZ J H,BRUNNER S,BIRNSTIEL M L,et al.The artificial antimicrobial peptide KLKLLLLLKLK induces predominantly a TH2-type immune response to co-injected antigens[J].Vaccine,2004,22(25/26):3274-3284.
[8] ZHANG H H,YANG X M,XIE Q M,et al.The Potent adjuvant effects of chicken β-defensin-1 when genetically fused with infectious bursal disease virus VP2 gene[J].Veterinary Immunology and Immunopathology,2010,136(1/2):92-97.
[9] ACOSTA J,CARPIO Y,VALDES I,et al.Co-administration of tilapia alpha-helical antimicrobial peptides with subunit antigens boost immunogenicity in mice and tilapia (
Oreochromis niloticus)[J].Vaccine,2014,32(2):223-229.
[10] OMAN T J,BOETTCHER J M,WANG H,et al.Sublancin is not a lantibiotic but an S-linked glycopeptides[J].Nature Chemical Biology,2011,7(2):78-80.
[11] STEPPER J,SHASTRI S,LOO T S,et al.Cysteine S-glycosylation,a new post-translational modification found in glycopeptide bacteriocins[J].FEBS Letters,2011,585(4):645-650.
[12] JI S Y,LI W L,BALOCH A R,et al.Improved production of sublancin
via introduction of three characteristic promoters into operon clusters responsible for this novel distinct glycopeptides biosynthesis[J].Microbial Cell Factries,2015,14:17.
[13] PAIK S H,CHAKICHERLA A,HANSEN J N.Identification and characterization of the structural and transporter genes for,and the chemical and biological properties of Sublancin 168,a novel lantibiotic produced by
Bacillus subtilis 168[J].The Journal of Biological Chemistry,1998,273(36):23134-23142.
[14] WANG Q W,ZENG X F,S WANG S,et al.The bacteriocin Sublancin attenuates intestinal injury in young mice infected with
Staphylococcus aureus[J].Anatomical Record,2014,297(8):1454-1461.
[15] WANG G S,LI X,WANG Z.APD3.The antimicrobial peptide database as a tool for research and education[J].Nucleic Acids Research,2015,44:D1087-D1093.
[16] KOUWEN T R H M,TRIP E N,DENHAM E L,et al.The large mechanosensitive channel mscl determines bacterial susceptibility to the bacteriocin Sublancin 168[J].Antimicrobial Agents and Chemotherapy,2009,53(11):4702-4711.
[17] YANG D,BIRAGYN A,HOOVER D M,et al.Multiple roles of antimicrobial defensins,cathelicidins,and eosinophil-derived neurotoxin in host defense[J].Annual Review of Immunology,2004,22(1):181-215.
[18] NICHOLLS E F,MADERA L,HANCOCK R E W.Immunomodulators as adjuvants for vaccines and antimicrobial therapy[J].Annals of the New York Academy of Sciences,2010,1213:46-61.
[19] BOMMINENI Y R,PHAM G H,SUNKARA L T,et al.Immune regulatory activities of fowlicidin-1,a cathelicidin host defense peptide[J].Molecular Immunology,2014,59(1):55-63.
[20] 曹雪涛.医学免疫学[M].6版.北京:人民卫生出版社,2013:49-110.
[21] 龚非力.医学免疫学[M].3版.北京:科学出版社,2009:167-168.
[22] FINKELMAN F D,HOLMES J,KATONA I M,et al.Lymphokine control of in vivo immunoglobulin isotype selection[J].Annual Review of Immunology,1990,8(1):303-333.
[23] MOHAN T,SHARMA C,BHAT A A,et al.Modulation of HIV peptide antigen specific cellular immune response by synthetic α-and β-defensin peptides[J].Vaccine,2013,31(13):1707-1716.
[24] KANG Y M,JIN H L,ZHENG G X,et al.The adjuvant effect of levamisole on killed viral vaccines[J].Vaccine,2005,23(48/49):5543-5550.
[25] MALIK F,SINGH J,KHAJURIA A,et al.A standardized root extract of
Withania somnifera and its major constituent with an olide-A elicit humoral and cell-mediated immune responses by up regulation of Th1-dominant polarization in BALB/c mice[J].Life Sciences,2007,80(16):1525-1538.
[26] GAUTAM M,SAHA S,BANI S,et al.Immunomodulatory activity of
Asparagus racemosus on systemic Th1/Th2 immunity:implications for immunoadjuvant potential[J].Journal of Ethnopharmacology,2009,121(2):241-247.
[27] ZHAI L J,LI Y T,WANG W Y,et al.Effect of oral administration of ginseng stem-and-leaf saponins(GSLS) on the immune responses to Newcastle disease vaccine in chickens[J].Vaccine,2011,29(31):5007-5014.
[28] HANCOCK R E W,DIAMOND G.The role of cationic antimicrobial peptides in innate host defences[J].Trends in Microbiology,2000,8(9):402-410.
[29] LILLARD J W,BOYAKA P N,CHERTOV O,et al.Mechanisms for induction of acquired host immunity by neutrophil peptide defensins[J].Proceedings of the National Academy of Sciences of the United States of America,1999,96(2):651-656.
[30] TANI K,MURPHY W J,CHERTOV O,et al.Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype and carrier antigens[J].International Immunolog,2000,12(5):691-700.
[31] AGGER E M,ROSENKRANDS I,OLSEN A W,et al.Protective immunity to tuberculosis with Ag85B-ESAT-6 in a synthetic cationic adjuvant system IC31[J].Vaccine,2006,24(26):5452-5460.
[32] DE GONZALO C V G,ZHU L Y,OMAN T J,et al.NMR structure of the S-linked glycopeptides sublancin 168[J].ACS Chemical,Biology,2014,9(3):796-801.
[33] BIRAGYN A,RUFFINI P A,LEIFER C A,et al.Toll-like receptor 4-dependent activation of dendritic cells by β-defensin 2[J].Science,2002,298(5595):1025-1029.
[34] VAN DER DOES A M,JOOSTEN S A,VROOMANS E,et al.The antimicrobial peptide hLF1-11 drives monocyte-dendritic cell differentiation toward dendritic cells that promote antifungal responses and enhance Th17 polarization[J].Journal of Innate Immunity,2012,4(3):284-292.
[35] PENA O M,AFACAN N,PISTOLIC J,et al.Synthetic cationic peptide IDR-1018 modulates human macrophage differentiation[J].PLoS One,2013,8(1):e52449.
