Molecular Nutrition

Effects of Mycotoxins on Intestinal Mucins and Its Action Mechanism

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  • 1. Ministry of Agriculture-Milk Risk Assessment Laboratory, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    2. Ministry of Agriculture-Milk and Dairy Product Inspection Center, Beijing 100193, China;
    3. State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received date: 2017-08-02

  Online published: 2018-02-02

Abstract

Mycotoxins are secondary metabolites produced by fungi in the field of cereal growth, harvest and storage or processing which is widely found in feed ingredients and human food. Mycotoxins not only reduce the quality of feed, but also seriously damage the health of animals, reduce animal production performance; its residues in animal products have a serious threat to human health. A large number of studies have shown that mycotoxins can damage the intestinal mucosal barrier, affecting the composition of intestinal flora, regulate intestinal immune response, induced intestinal lesions and finally causing intestinal inflammation. The mucins secreted by intestinal goblet cells, the main component of the mucus layer function as the intestine innate immune first defense line. Intestinal mucins play an important role in maintaining the dynamic balance of the intestinal mucosa and regulating the microbial-host immune response. The effects of mycotoxins on intestinal mucins and underlying mechanism were reviewed in this paper, which provided a theoretical basis for further researches in this field.

Cite this article

HUANG Xin, GAO Ya, WANG Jiaqi, ZHENG Nan . Effects of Mycotoxins on Intestinal Mucins and Its Action Mechanism[J]. Chinese Journal of Animal Nutrition, 2018 , 30(2) : 476 -483 . DOI: 10.3969/j.issn.1006-267x.2018.02.010

References

[1] IQBAL S Z,ASI M R,ARIÑO A.Aflatoxin M1 contamination in cow and buffalo milk samples from the North West Frontier Province (NWFP) and Punjab provinces of Pakistan[J].Food Additives and Contaminants Part B:Surveillance,2011,4(4):282-288.  

[2] 李晓晗.浅谈饲料中霉菌毒素的危害[J].甘肃畜牧兽医,2016,46(16):51.

[3] 龙定彪,罗敏,肖融,等.霉菌毒素及其毒性效应的研究进展[J].黑龙江畜牧兽医,2015(11):77-79.

[4] 易中华,吴兴利.饲料中常见霉菌毒素间的毒性互作效应[J].饲料研究,2009(1):15-18.

[5] ZIELONKA ?,ZWIERZCHOWSKI W,OBREMSKI K,et al.Evaluation of selected indicators of immune response (IL-1,IL-4,IL-6,SAA,and Hp) in pigs fed diets containing deoxynivalenol,T-2 toxin,and zearalenone[J].Bulletin-Veterinary Institute in Pulawy,2010,54(4):631-635.

[6] GAJECKA M,JAKIMIUK E,ZIELONKA ?,et al.The biotransformation of chosen mycotoxins[J].Polish Journal of Veterinary Sciences,2009,12(2):293-303.

[7] GILL N,WLODARSKA M,FINLAY B B.Roadblocks in the gut:barriers to enteric infection[J].Cellular Microbiology,2011,13(5):660-669.  

[8] TARABOVA L,MAKOVA Z,PIESOVA E,et al.Intestinal mucus layer and mucins (a review)[J].Folia Veterinaria,2016,60(1):21-25.

[9] VAN KLINKEN B J W,DEKKER J,VAN GOOL S A,et al.MUC5B is the prominent mucin in human gallbladder and is also expressed in a subset of colonic goblet cells[J].American Journal of Physiology,1998,274(5):G871-G878.

[10] ANTONISSEN G,VAN IMMERSEEL F,PASMANS F,et al.Mycotoxins deoxynivalenol and fumonisins alter the extrinsic component of intestinal barrier in broiler chickens[J].Journal of Agricultural and Food Chemistry,2015,63(50):10846-10855.  

[11] HO S B,NIEHANS G A,LYFTOGT C,et al.Heterogeneity of mucin gene expression in normal and neoplastic tissues[J].Cancer Research,1993,53(3):641-651.

[12] 于秀文,安锦丹,王静芬.黏蛋白MRC1及MUC2与胃肠道肿瘤的相关性研究进展[J].医学研究杂志,2003,32(11):30-32.

[13] LINDÉN S K,FLORIN T H J,MCGUCKIN M A.Mucin dynamics in intestinal bacterial infection[J].PLoS One,2008,3(12):e3952.

[14] VERSANTVOORT C H,OOMEN A G,VAN D,et al.Applicability of an in vitro digestion model in assessing the bioaccessibility of mycotoxins from food[J].Food and Chemical Toxicology,2005,43(1):31-40.  

[15] MEHROTRA R,THORNTON D J,SHEEHAN J K.Isolation and physical characterization of the MUC7(MG2) mucin from saliva:evidence for self-association[J].Biochemical Journal,1998,334(2):415-422.  

[16] SHENG Y H,HASNAIN S Z,FLORIN T H,et al.Mucins in inflammatory bowel diseases and colorectal cancer[J].Journal of Gastroenterology and Hepatology,2012,27(1):28-38.  

[17] DEKKER J,ROSSEN J W A,BVLLER H A,et al.The MUC family:an obituary[J].Trends in Biochemical Sciences,2002,27(3):126-131.  

[18] JOHANSSON M E V,HANSSON G C.Immunological aspects of intestinal mucus and mucins[J].Nature Reviews Immunology,2016,16(10):639-649.  

[19] BARTMAN A E,BUISINE M P,AUBERT J P,et al.The MUC6 secretory mucin gene is expressed in a wide variety of epithelial tissues[J].The Journal of Pathology,1998,186(4):398-405.  

[20] WILLIAMS S J,MCGUCKIN M A,GOTLEY D C,et al.Two novel mucin genes down-regulated in colorectal cancer identified by differential display[J].Cancer Research,1999,59(16):4083-4089.

[21] GUM J R,Jr,CRAWLEY S C,HICKS J W,et al.MUC17,a novel membrane-tethered mucin[J].Biochemical and Biophysical Research Communications,2002,291(3):466-475.  

[22] CARRAWAY K L,FUNES M,WORKMAN H C,et al.Contribution of membrane mucins to tumor progression through modulation of cellular growth signaling pathways[J].Current Topics in Developmental Biology,2007,78:1-22.

[23] VELCICH A,YANG W C,HEYER J,et al.Colorectal cancer in mice genetically deficient in the mucin MUC2[J].Science,2002,295(5560):1726-1729.  

[24] MCAULEY J L,LINDEN S K,PNG C W,et al.MUC1 cell surface mucin is a critical element of the mucosal barrier to infection[J].Journal of Clinical Investigation,2007,117(8):2313-2324.  

[25] UENO K,KOGA T,KATO K,et al.MUC1 mucin is a negative regulator of Toll-like receptor signaling[J].American Journal of Respiratory Cell and Molecular Biology,2008,38(3):263-268.  

[26] KUFE D W.Mucins in cancer:function,prognosis and therapy[J].Nature Reviews Cancer,2009,9(12):874-885.  

[27] STROUS G J,DEKKER J.Mucin-type glycoproteins[J].Critical Reviews in Biochemistry and Molecular Biology,1992,27(1/2):57-92.

[28] APPLEGATE T J,SCHATZMAYR G,PRICKEL K,et al.Effect of aflatoxin culture on intestinal function and nutrient loss in laying hens[J].Poultry Science,2009,88(6):1235-1241.  

[29] BRACARENSE A P F L,LUCIOLI J,GRENIER B,et al.Chronic ingestion of deoxynivalenol and fumonisin,alone or in interaction,induces morphological and immunological changes in the intestine of piglets[J].British Journal of Nutrition,2012,107(12):1776-1786.  

[30] WAN M L Y,TURNER P C,ALLEN K J,et al.Lactobacillus rhamnosus GG modulates intestinal mucosal barrier and inflammation in mice following combined dietary exposure to deoxynivalenol and zearalenone[J].Journal of Functional Foods,2016,22:34-43.

[31] WAN L Y M,ALLEN K J,TURNER P C,et al.Modulation of Mucin mRNA (MUC5AC and MUC5B) expression and protein production and secretion in Caco-2/HT29-MTX co-cultures following exposure to individual and combined Fusarium mycotoxins[J].Toxicological Sciences,2014,139(1):83-98.  

[32] PINTON P,GRAZIANI F,PUJOL A,et al.Deoxynivalenol inhibits the expression by goblet cells of intestinal mucins through a PKR and MAP kinase dependent repression of the resistin-like molecule β[J].Molecular Nutrition & Food Research,2015,59(6):1076-1087.  

[33] ANTONISSEN G,MARTEL A,PASMANS F,et al.The impact of Fusarium mycotoxins on human and animal host susceptibility to infectious diseases[J].Toxins,2014,6(2):430-452.  

[34] PESTKA J J.Deoxynivalenol:mechanisms of action,human exposure,and toxicological relevance[J].Archives of Toxicology,2010,84(9):663-679.  

[35] PINTON P,OSWALD I P.Effect of deoxynivalenol and other Type B trichothecenes on the intestine:a review[J].Toxins,2014,6(5):1615-1643.  

[36] ARUNACHALAM C,DOOHAN F M.Trichothecene toxicity in eukaryotes:cellular and molecular mechanisms in plants and animals[J].Toxicology Letters,2013,217(2):149-158.  

[37] MARESCA M,FANTINI J.Some food-associated mycotoxins as potential risk factors in humans predisposed to chronic intestinal inflammatory diseases[J].Toxicon,2010,56(3):282-294.  

[38] NAGASHIMA H.Toxicity of trichothecene mycotoxin nivalenol in human leukemia cell line HL60[J].JSM Mycotoxins,2015,65(1):11-17.  

[39] WAN L Y M,WOO C S J,TURNER P C,et al.Individual and combined effects of Fusarium toxins on the mRNA expression of pro-inflammatory cytokines in swine jejunal epithelial cells[J].Toxicology Letters,2013,220(3):238-246.  

[40] MARESCA M,YAHI N,YOUNES-SAKR L,et al.Both direct and indirect effects account for the pro-inflammatory activity of enteropathogenic mycotoxins on the human intestinal epithelium:stimulation of interleukin-8 secretion, potentiation of interleukin-1β effect and increase in the transepithelial passage of commensal bacteria[J].Toxicology and Applied Pharmacology,2008,228(1):84-92.  

[41] AHN D H,CRAWLEY S C,HOKARI R,et al.TNF-alpha activates MUC2 transcription via NF-kappaB but inhibits via JNK activation[J].Cellular Physiology and Biochemistry,2005,15(1/2/3/4):29-40.

[42] PERRAIS M,PIGNY P,DUCOUROUBLE M P,et al.Characterization of human mucin gene MUC4 promoter:importance of growth factors and proinflammatory cytokines for its regulation in pancreatic cancer cells[J].Journal of Biological Chemistry,2001,276(33):30923-30933.  

[43] SHEKELS L L,HO S B.Characterization of the mouse MUC3 membrane bound intestinal mucin 5' coding and promoter regions:regulation by inflammatory cytokines[J].Biochimica et Biophysica Acta:Gene Structure and Expression,2003,1627(2/3):90-100.

[44] OTERO M,LAGO R,LAGO F,et al.Leptin,from fat to inflammation:old questions and new insights[J].FEBS Letters,2005,579(2):295-301.  

[45] EL HOMSI M,DUCROC R,CLAUSTRE J,et al.Leptin modulates the expression of secreted and membrane-associated mucins in colonic epithelial cells by targeting PKC,PI3K,and MAPK pathways[J].American Journal of Physiology,2007,293(1):G365-G373.

[46] 冯光德.自然霉变玉米对肉鸭生产性能和消化生理的影响及机制研究[D].博士学位论文.雅安:四川农业大学,2011.
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