[1] 余超.生物素对围产期奶牛泌乳净能和代谢蛋白平衡及生产性能的影响[D].硕士学位论文.杨凌:西北农林科技大学,2016.
[2] 孙菲菲,曹阳春,李生祥,等.胆碱对奶牛围产期代谢的调控[J].动物营养学报,2014,26(1):26-33.
[3] 孙菲菲.胆碱和蛋氨酸对奶牛围产期营养平衡和机体健康的影响及机制[D].博士学位论文.杨凌:西北农林科技大学,2017.
[4] LI C,BATISTEL F,OSORIO J S,et al.Peripartal rumen-protected methionine supplementation to higher energy diets elicits positive effects on blood neutrophil gene networks,performance and liver lipid content in dairy cows[J].Journal of Animal Science and Biotechnology,2016,7(1):18.
[5] OSORIO J,TREVISI E,JI P,et al.Biomarkers of inflammation,metabolism,and oxidative stress in blood,liver,and milk reveal a better immunometabolic status in peripartal cows supplemented with Smartamine M or MetaSmart[J].Journal of Dairy Science,2014,97(12):7437-7450.

[6] OSORIO J,JI P,DRACKLEY J,et al.Smartamine M and MetaSmart supplementation during the peripartal period alter hepatic expression of gene networks in 1-carbon metabolism,inflammation,oxidative stress,and the growth hormone-insulin-like growth factor 1 axis pathways[J].Journal of Dairy Science,2014,97(12):7451-7464.

[7] JACOMETO C B,ZHOU Z,LUCHINI D,et al.Maternal supplementation with rumen-protected methionine increases prepartal plasma methionine concentration and alters hepatic mRNA abundance of 1-carbon,methionine,and transsulfuration pathways in neonatal Holstein calves[J].Journal of Dairy Science,2017,100(4):3209-3219.

[8] NAN X M,BU D P,LI X Y,et al.Ratio of lysine to methionine alters expression of genes involved in milk protein transcription and translation and mTOR phosphorylation in bovine mammary cells[J].Physiological Genomics,2014,46(7):268-275.

[9] 胡诚军,江青艳,孔祥峰.畜禽蛋氨酸代谢及其生理功能研究进展[J].饲料工业,2016,37(15):23-27.
[10] ARDALAN M,DEHGHAN-BANADAKY M,REZAYAZDI K,et al.The effect of rumen-protected methionine and choline on plasma metabolites of Holstein dairy cows[J].The Journal of Agricultural Science,2011,149(5):639-646.

[11] SUN F F,CAO Y C,CAI C J,et al.Regulation of nutritional metabolism in transition dairy cows:energy homeostasis and health in response to post-ruminal choline and methionine[J].PLoS One,2016,11(8):e0160659.
[12] ZHOU Z,BULGARI O,VAILATI-RIBONI M,et al.Rumen-protected methionine compared with rumen-protected choline improves immunometabolic status in dairy cows during the peripartal period[J].Journal of Dairy Science,2016,99(11):8956-8969.

[13] SAHOO A,SOREN N.Nutrition for wool production[J].Webmedcentral Nutrition,2011,2(10):WMC002384.
[14] ZHOU Z,VAILATI-RIBONI M,TREVISI E,et al.Better postpartal performance in dairy cows supplemented with rumen-protected methionine compared with choline during the peripartal period[J].Journal of Dairy Science,2016,99(11):8716-8732.

[15] SINCLAIR K D,GARNSWORTHY P C,MANN G E,et al.Reducing dietary protein in dairy cow diets:implications for nitrogen utilization,milk production,welfare and fertility[J].Animal,2014,8(2):262-274.

[16] WANG C,LIU H Y,WANG Y M,et al.Effects of dietary supplementation of methionine and lysine on milk production and nitrogen utilization in dairy cows[J].Journal of Dairy Science,2010,93(8):3661-3670.

[17] HUANG X,ZANG Y L,ZHANG M H,et al.Nuclear factor of κB1 is a key regulator for the transcriptional activation of milk synthesis in bovine mammary epithelial cells[J].DNA and Cell Biology,2017,36(4):295-302.

[18] OSORIO J S,JACOMETO C B,ZHOU Z,et al.Hepatic global DNA and peroxisome proliferator-activated receptor alpha promoter methylation are altered in peripartal dairy cows fed rumen-protected methionine[J].Journal of Dairy Science,2016,99(1):234-244.

[19] ZHOU Z,GARROW T A,DONG X W,et al.Hepatic activity and transcription of betaine-homocysteine methyltransferase,methionine synthase,and cystathionine synthase in periparturient dairy cows are altered to different extents by supply of methionine and choline[J].The Journal of Nutrition,2017,147(1):11-19.

[20] CHANDLER T L,WHITE H M.Choline and methionine differentially alter methyl carbon metabolism in bovine neonatal hepatocytes[J].PLoS One,2017,12(2):e0171080.
[21] SODER K J,HOLDEN L A.Lymphocyte proliferation response of lactating dairy cows fed varying concentrations of rumen-protected methionine[J].Journal of Dairy Science,1999,82(9):1935-1942.

[22] OSORIO J,JI P,DRACKLEY J K,et al.Supplemental Smartamine M or MetaSmart during the transition period benefits postpartal cow performance and blood neutrophil function[J].Journal of Dairy Science,2013,96(10):6248-6263.

[23] DENG Q,MA D,SHI Z,et al.Effects of
β-hydroxybutyricacid on the synthesis and assembly of very low-density lipoprotein in bovine hepatocytes
in vitro[J].Journal of Animal Physiology and Animal Nutrition,2016,100(2):331-336.

[24] LI Y,DING H Y,WANG X C,et al.High levels of acetoacetate and glucose increase expression of cytokines in bovine hepatocytes,through activation of the NF-κB signalling pathway[J].Journal of Dairy Research,2016,83(1):51-57.

[25] SHI X,LI X,LI D,et al.
β-hydroxybutyrate activates the NF-κB signaling pathway to promote the expression of pro-inflammatory factors in calf hepatocytes[J].Cellular Physiology and Biochemistry,2014,33(4):920-932.

[26] SHI X X,LI D D,DENG Q H,et al.NEFAs activate the oxidative stress-mediated NF-κB signaling pathway to induce inflammatory response in calf hepatocytes[J].The Journal of Steroid Biochemistry and Molecular Biology,2015,145:103-112.
[27] LACETERA N,FRANCI O,SCALIA D,et al.Effects of nonesterified fatty acids and
β-hydroxybutyrate on functions of mononuclear cells obtained from ewes[J].American Journal of Veterinary Research,2002,63(3):414-418.

[28] LACETERA N,SCALIA D,FRANCI O,et al.Short communication:effects of nonesterified fatty acids on lymphocyte function in dairy heifers[J].Journal of Dairy Science,2004,87(4):1012-1014.

[29] LACETERA N,SCALIA D,BERNABUCCI U,et al.Lymphocyte functions in overconditioned cows around parturition[J].Journal of Dairy Science,2005,88(6):2010-2016.

[30] VAILATI-RIBONI M,OSORIO J S,TREVISI E,et al.Supplemental Smartamine M in higher-energy diets during the prepartal period improves hepatic biomarkers of health and oxidative status in Holstein cows[J].Journal of Animal Science and Biotechnology,2017,8(1):17.
[31] AWAWDEH M S.Rumen-protected methionine and lysine:effects on milk production and plasma amino acids of dairy cows with reference to metabolisable protein status[J].Journal of Dairy Research,2016,83(2):151-155.

[32] ROBINSON P H.Impacts of manipulating ration metabolizable lysine and methionine levels on the performance of lactating dairy cows:A systematic review of the literature[J].Livestock Science,2010,127(2/3):115-126.
[33] ZANTON G I,BOWMAN G R,VÁZQUEZ-AÑÍN M,et al.Meta-analysis of lactation performance in dairy cows receiving supplemental dietary methionine sources or postruminal infusion of methionine[J].Journal of Dairy Science,2014,97(11):7085-7101.

[34] ACOSTA D A V,DENICOL A C,TRIBULO P,et al.Effects of rumen-protected methionine and choline supplementation on the preimplantation embryo in Holstein cows[J].Theriogenology,2016,85(9):1669-1679.

[35] DALBACH K F,LARSEN M,RAUN B M L,et al.Effects of supplementation with 2-hydroxy-4-(methylthio)-butanoic acid isopropyl ester on splanchnic amino acid metabolism and essential amino acid mobilization in postpartum transition Holstein cows[J].Journal of Dairy Science,2011,94(8):3913-3927.

[36] ARDALAN M,REZAYAZDI K,DEHGHAN-BANADAKY M.Effect of rumen-protected choline and methionine on physiological and metabolic disorders and reproductive indices of dairy cows[J].Journal of Animal Physiology and Animal Nutrition,2010,94(6):e259-e265.
[37] ORDWAY R S,BOUCHER S E,WHITEHOUSE N L,et al.Effects of providing two forms of supplemental methionine to periparturient Holstein dairy cows on feed intake and lactational performance[J].Journal of Dairy Science,2009,92(10):5154-5166.

[38] SOCHA M T,PUTNAM D E,GARTHWAITE B D,et al.Improving intestinal amino acid supply of pre-and postpartum dairy cows with rumen-protected methionine and lysine[J].Journal of Dairy Science,2005,88(3):1113-1126.

[39] PHILLIPS G J,CITRON T L,SAGE J S,et al.Adaptations in body muscle and fat in transition dairy cattle fed differing amounts of protein a