[1] 胡越,许军,刘燕华,等.PPARα激动剂降血脂作用的研究进展[J].中国药科大学学报,2016,47(1):118-124.
[2] 金鹏,陈保林,杨永曜.PPARα/PGC-1α信号通路对阿霉素损伤h9c2心肌细胞能量代谢的调节[J].临床心血管病杂志,2016,32(4):388-391.
[3] NAEEM A.Effect of age and dietary plane of nutrition on transcript profiles of ruminal tissue of Holstein bull calves[D].Ph.D.Thesis.Urbana:University of Illinois at Urbana-Champaign,2012.
[4] WANG W M,CHONG L,LI F D,et al.Effects of early feeding on the host rumen transcriptome and bacterial diversity in lambs[J].Scientific Reports,2016,6:32479.
[5] KINOSHITA M,SUZUKI Y,SAITO Y.Butyrate reduces colonic paracellular permeability by enhancing PPARγ activation[J].Biochemical and Biophysical Research Communications,2002,293(2):827-831.
[6] WANG L J,CHEN L,TAN Y Z,et al.Betaine supplement alleviates hepatic triglyceride accumulation of apolipoprotein E deficient mice via reducing methylation of peroxisomal proliferator-activated receptor alpha promoter[J].Lipids in Health and Disease,2013,12(1):34.
[7] JIAO J Z,LI X P,BEAUCHEMIN K A,et al.Rumen development process in goats as affected by supplemental feeding v.Grazing:age-related anatomic development,functional achievement and microbial colonisation[J].British Journal of Nutrition,2015,113(6):888-900.
[8] GEORGIADI A,KERSTEN S.Mechanisms of gene regulation by fatty acids[J].Advances in Nutrition,2012,3(2):127-134.
[9] 林圣宸.核受体PPARs家族与新型激动剂的结构与功能研究[D].博士学位论文.厦门:厦门大学,2013.
[10] WAKU T,SHIRAKI T,OYAMA T,et al.Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids[J].Journal of Molecular Biology,2009,385(1):188-199.
[11] FERRÉ P.The biology of peroxisome proliferator-activated receptors:Relationship with lipid metabolism and insulin sensitivity[J].Diabetes,2004,53(1S):43-50.
[12] 杨亚维,袁杰.PPARα抗氧化应激作用的研究进展[J].东南大学学报(医学版),2016,35(1):147-150.
[13] NAEEM A,DRACKLEY J K,STAMEY J,et al.Role of metabolic and cellular proliferation genes in ruminal development in response to enhanced plane of nutrition in neonatal Holstein calves[J].Journal of Dairy Science,2012,95(4):1807-1820.
[14] COLLET N,THÉOLEYRE S,RAGEUL J,et al.PPARγ is functionally expressed in clear cell renal cell carcinoma[J].International Journal of Oncology,2011,38(3):851-857.
[15] BIONAZ M,CHEN S W,KHAN M J,et al.Functional role of PPARs in ruminants:potential targets for fine-tuning metabolism during growth and lactation[J].PPAR Research,2013,2013:684159.
[16] PYPER S R,NAVIN V,YU S T,et al.PPARα:energy combustion,hypolipidemia,inflammation and cancer[J].Nuclear Receptor Signaling,2010,8:e002.
[17] 王丽,那威,王宇祥,等.鸡PPARγ基因的表达特性及其对脂肪细胞增殖分化的影响[J].遗传,2012,34(4):454-464.
[18] CAPPON G D,LIU R C M,FRAME S R,et al.Effects of the rat hepatic peroxisome proliferator,wyeth 14,643,on the lactating goat[J].Drug and Chemical Toxicology,2002,25(3):255-266.
[19] SCHLEGEL G,KELLER J,HIRCHE F,et al.Expression of genes involved in hepatic carnitine synthesis and uptake in dairy cows in the transition period and at different stages of lactation[J].BMC Veterinary Research,2012,8:28.
[20] BRENNAN K M,MICHAL J J,RAMSEY J J,et al.Body weight loss in beef cows:Ⅰ.The effect of increased β-oxidation on messenger ribonucleic acid levels of uncoupling proteins two and three and peroxisome proliferator-activated receptor in skeletal muscle[J].Journal of Animal Science,2009,87(9):2860-2866.
[21] GARCÍA-ROJAS P,ANTARAMIAN A,GONZÁLEZ-DÁVALOS L,et al.Induction of peroxisomal proliferator-activated receptor gamma and peroxisomal proliferator-activated receptor gamma coactivator 1 by unsaturated fatty acids,retinoic acid,and carotenoids in preadipocytes obtained from bovine white adipose tissue[J].Journal of Animal Science,2010,88(5):1801-1808.
[22] SHARMA S,SUN X T,RAFIKOV R,et al.PPAR-gamma regulates carnitine homeostasis and mitochondrial function in a lamb model of increased pulmonary blood flow[J].PLoS One,2012,7(9):e41555.
[23] PENNER G B,STEELE M A,ASCHENBACH J R,et al.Ruminant Nutrition Symposium:Molecular adaptation of ruminal epithelia to highly fermentable diets[J].Journal of Animal Science,2011,89(4):1108-1119.
[24] CONNOR E E,BALDWIN R L,WALKER M P,et al.Transcriptional regulators transforming growth factor-β1 and estrogen-related receptor-α identified as putative mediators of calf rumen epithelial tissue development and function during weaning[J].Journal of Dairy Science,2014,97(7):4193-4207.
[25] LIN Z F,PAN X B,WU F,et al.Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and induction of adiponectin in mice[J].Circulation,2015,131(21):1861-1871.
[26] OKINE B N,SPICER C,MILLNS P,et al.Systemic administration of WY-14643,a selective synthetic agonist of peroxisome proliferator activator receptor-alpha,alters spinal neuronal firing in a rodent model of neuropathic pain[J].Scandinavian Journal of Pain,2015,9:42-48.
[27] 沈桂佳,安鹏,聂玉强,等.PPAR-β/δ及其激动剂l165041对小鼠肝脏成瘤的影响[J].胃肠病学和肝病学杂志,2015,24(11):1350-1353.
[28] HARMS M,SEALE P.Brown and beige fat:development,function and therapeutic potential[J].Nature Medicine,2013,19(10):1252-1263.
[29] RUBY M A,GOLDENSON B,ORASANU G,et al.VLDL hydrolysis by LPL activates PPAR-α through generation of unbound fatty acids[J].Journal of Lipid Research,2010,51(8):2275-2281.
[30] DENGLER F,RACKWITZ R,BENESCH F,et al.Both butyrate incubation and hypoxia upregulate genes involved in the ruminal transport of SCFA and their metabolites[J].Journal of Animal Physiology and Animal Nutrition,2015,99(2):379-390.
[31] KHAN S A,HEUVEL J P V.Reviews:current topicsrole of nuclear receptors in the regulation of gene expression by dietary fatty acids (review)[J].Journal of Nutritional Biochemistry,2003,14(10):554-567.
[32] HUSS J M,TORRA I P,STAELS B,et al.Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle[J].Molecular & Cellular Biology,2004,24(20):9079-9091.
[33] SHAO D,LIU Y,LIU X J,et al.PGC-1β-Regulated mitochondrial biogenesis and function in myotubes is mediated by NRF-1 and ERRα[J].Mitochondrion,2010,10(5):516-527.
[34] 丁勇,许超,吴季辉,等.表观遗传学研究进展[J].中国科学(生命科学),2017,47(1):3-15.
[35] 唐丹,周永健,李瑜元,等.姜黄素对脂肪变性肝细胞过氧化物酶体增殖物活化受体-α的去甲基化作用[J].广东医学,2014,35(2):175-179.
[36] KIRCHNER H,SINHA I,GAO H,et al.Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients[J].Molecular Metabolism,2016,5(3):171-183.
[37] OHASHI K,MUNETSUNA E,YAMADA H,et al.High fructose consumption induces DNA methylation at PPARα and CPT1A promoter regions in the rat liver[J].Biochemical & Biophysical Research Communications,2015,468(1/2):185-189.
[38] OSORIO J S,JACOMETO C B,ZHOU Z,et al.Hepatic global DNA and peroxisome proliferator-activated receptor alpha promoter methylation are altered in peripartal dairy cows fed rumen-protected methionine[J].Journal of Dairy Science,2016,99(1):234-244.
[39] 王洁,张心怡,郝彩丽,等.组蛋白去乙酰化酶抑制剂的研究进展[J].现代生物医学进展,2014,14(14):2783-2785.
[40] MYZAK M C,DASHWOOD R H.Histone deacetylases as targets for dietary cancer preventive agents:Lessons learned with butyrate,diallyl disulfide,and sulforaphane[J].Current Drug Targets,2006,7(4):443-452.
