In order to find methods for relieving oxidative and immune stress, and promote growth of yaks with growth retardation, forty 1-year-old Qinghai high plateau yaks with growth retardation (which was 1.5-fold standard deviations less than the average weight of yak groups with same age and breed) were selected and randomly assigned into 4 groups, which were farming yaks with growth retardation group, concentrate group, cysteamine group (concentrate+80 mg/kg BW cysteamine) and yeast group (concentrate+0.3% active dry yeast); another ten 1-year-old Qinghai high plateau yaks with normal growth performance were selected as farming healthy yaks group. Each group had 5 replicates with 2 yaks per replicate. The pre-trial lasted for 15 d, and the trial lasted for 60 d. The results showed as follows:1) compared with farming yaks with retardation group, body measurements in concentrate group, cysteamine group and yeast group were significantly increased (P<0.05). 2) Compared with farming yaks with retardation group, concentrate group had significantly higher red blood cell count and hemoglobin content, and significantly lower white blood cell count in blood (P<0.05). 3) On day 1, plasma malondialdehyde (MDA) content in farming healthy yaks group were significantly lower than that in the other four groups (P<0.05), and plasma total superoxide dismutase (T-SOD) activity, glutathione peroxidase (GSH-Px) content and the total antioxidant capacity(T-AOC) in farming healthy yaks group were significantly higher than those in the other four groups (P<0.05). On day 60, plasma MDA content in cysteamine group and yeast group was significantly decreased compared with day 1 (P<0.05), and was significantly lower than that farming yaks with retardation group (P<0.05); plasma T-SOD activity and total antioxidant capacity (T-AOC) in cysteamine group and yeast group were significantly increased compared with day 1 (P<0.05), and were significantly higher than those farming yaks with retardation group (P<0.05); plasma GSH-Px content in yeast group was significantly increased compared with day 1 (P<0.05), and was significantly higher than that in farming yaks with retardation group (P<0.05). 4)On day 1, plasma immunoglobulin A (IgA) and immunoglobulin G (IgG) contents in farming healthy yaks group were significantly higher than those in the other four group (P<0.05). On day 60, plasma IgG content in concentrate group was significantly increased compared with day 1 (P<0.05), and was significantly higher than that in farming yaks with retardation group (P<0.05); plasma IgA content in cysteamine group was significantly increased compared with day 1 (P<0.05), and was significantly higher than that in farming yaks with retardation group (P<0.05); plasma IgA and IgG contents in yeast group were significantly increased compared with day 1 (P<0.05), and were significantly higher than that in farming yaks with retardation group (P<0.05). The results indicate that concentrate supplementation and further supplementation of 80 mg/kg BW cysteamine and 0.3% active dry yeast can improve antioxidant capacity and immunity of yaks with growth retardation, and promote compensatory growth; the supplementation of concentrate and 0.3% active dry yeast has the best effects.