Effects of Attapulgite Nano Zinc Oxide on Growth Performance, Organ Indices and Blood Biochemical Indices of Weaned Piglets

MAO Junzhou, DONG Li, WANG Shu, PENG Zhong, ZHONG Zhaoxin, QU Guomin, YU Lihuai

doi:10.3969/j.issn.1006-267x.2018.04.031

2018 , Vol. 30 >Issue 4: 1471 - 1480

DOI: https://doi.org/10.3969/j.issn.1006-267x.2018.04.031

Molecular Nutrition

Effects of Attapulgite Nano Zinc Oxide on Growth Performance, Organ Indices and Blood Biochemical Indices of Weaned Piglets

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1. College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China;
2. Animal Disease Prevention and Control Center of Liyang, Changzhou 213300, China

Received date: 2017-09-30

Online published: 2018-04-03

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Abstract

The experiment was conducted to explore the effects of attapulgite nano zinc oxide on the growth performance, organ indices and blood biochemical indices of weaned piglets. A total of 210 Duroc×Landrace×Yorkshire piglets with 21-day-old and similar body weight of (6.30±0.51) kg were randomly allocated into 7 groups with 6 replicates each and 5 pigs in each replicate. Pigs in the control group (CON group) were fed a basal diet, in antibiotic group (ANT group) were fed a basal diet supplemented with 100 mg/kg 50% olaquindox, 150 mg/kg 15% chlortetracycline and 50 mg/kg 10% sulfate colistin, and in the other groups were fed the basal diet supplemented with 3 000 mg/kg zinc oxide (ZO group), 800 mg/kg nano-zinc oxide (NZO group), and 700, 1 000 and 1 300 mg/kg attapulgite nano zinc oxide (LA-ZO group, MA-ZO group and HA-ZO group), respectively. The experiment lasted for 9 days after 3 days adaption. The results showed as follows:1) compared with CON group, dietary attapulgite nano zinc oxide significantly increased the average daily feed intake and average daily gain of weaned piglets (P<0.05). 2) Compared with CON group and ANT group, the diarrhea rate in LA-ZO group was significantly decreased (P<0.05). The diarrhea index in LA-ZO group was significantly lower than that in CON group, ANT group and NZO group (P<0.05). 3) The pancreas index in LA-ZO group and MA-ZO group was significantly higher than that in NZO group (P<0.05). 4) Compared with CON group, the contents of blood total cholesterol (TC) and triglyceride (TG) in MA-ZO group was significantly decreased (P<0.05), and the blood high density lipoprotein content in MA-ZO group was significantly increased (P<0.05), which was significantly higher than that in ANT group and NZO group (P<0.05). The blood high density lipoprotein content in HA-ZO group was significantly higher than that in CON group and ANT group (P<0.05). The results indicate that dietary attapulgite nano-zinc oxide can improve the growth performance, decrease the diarrhea rate, and promote the growth and development of weaned piglets, meanwhile decrease the contents of TG and TC in blood, increase blood high density lipoprotein content, strengthen lipid metabolism and pancreas development. Thus, it has potential to replace the utilization of antibiotics and high zinc for weaned piglets.

Key words： attapulgite nano zinc oxide; weaned piglets; growth performance; organ index; blood biochemical index

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MAO Junzhou, DONG Li, WANG Shu, PENG Zhong, ZHONG Zhaoxin, QU Guomin, YU Lihuai . Effects of Attapulgite Nano Zinc Oxide on Growth Performance, Organ Indices and Blood Biochemical Indices of Weaned Piglets[J]. Chinese Journal of Animal Nutrition, 2018 , 30(4) : 1471 -1480 . DOI: 10.3969/j.issn.1006-267x.2018.04.031

References

[1] HU C H,SONG J,YOU Z T,et al.Zinc oxide-montmorillonite hybrid influences diarrhea,intestinal mucosal integrity,and digestive enzyme activity in weaned pigs[J].Biological Trace Element Research,2012,149(2):190-196.

[2] HOFER U.Microbiome:effects of in-feed antibiotics on pig microbiota[J].Nature Reviews Microbiology,2014,12(4):234-234.

[3] BARTON M D.Antibiotic use in animal feed and its impact on human health[J].Nutrition Research Reviews,2000,13(2):279-299.

[4] SAHOO A,SWAIN R K,MISHRA S K.Effect of inorganic,organic and nano zinc supplemented diets on bioavailability and immunity status of broilers[J].International Journal of Advanced Research,2014,2(11):828-837.

[5] SWAIN P S,RAJENDRAN D,RAO S B N,et al.Preparation and effects of nano mineral particle feeding in livestock:a review[J].Veterinary World,2015,8(7):888-891.

[6] 田丽娜,姜建阳,朱风华,等.纳米氧化锌对肉鸡生长性能和屠宰性能的影响[J].中国农学通报,2009,25(2):1-5.

[7] MISHRA A,SWAIN R K,MISHRA S K,et al.Growth performance and serum biochemical parameters as affected by nano zinc supplementation in layer chicks[J].Indian Journal of Animal Nutrition,2014,31(4):384-388.

[8] SAHOO A,SWAIN R K,MISHRA S K,et al.Serum biochemical indices of broiler birds fed on inorganic,organic and nano zinc supplemented diets[J].International Journal of Recent Scientific Research,2014,5(11):2078-2081.

[9] ZHAO C Y,TAN S X,XIAO X Y,et al.Effects of dietary zinc oxide nanoparticles on growth performance and antioxidative status in broilers[J].Biological Trace Element Research,2014,160(3):361-367.

[10] LONG L N,CHEN J S,ZHANG Y G,et al.Comparison of porous and nano zinc oxide for replacing high-dose dietary regular zinc oxide in weaning piglets[J].PLoS One,2017,12(8):e0182550.

[11] SWAIN P S,RAO S B N,RAJENDRAN D,et al.Nano zinc,an alternative to conventional zinc as animal feed supplement:a review[J].Animal Nutrition,2016,2(3):134-141.

[12] WANG B,FENG W Y,WANG M,et al.Acute toxicological impact of nano-and submicro-scaled zinc oxide powder on healthy adult mice[J].Journal of Nanoparticle Research,2008,10(2):263-276.

[13] CHEN H,WANG A Q.Kinetic and isothermal studies of lead ion adsorption onto palygorskite clay[J].Journal of Colloid and Interface Science,2007,307(2):309-316.

[14] WANG W B,TIAN G Y,ZHANG Z F,et al.A simple hydrothermal approach to modify palygorskite for high-efficient adsorption of methylene blue and Cu(Ⅱ) ions[J].Chemical Engineering Journal,2015,265:228-238.

[15] ZHOU S Y,XUE A L,ZHANG Y,et al.Novel polyamidoamine dendrimer-functionalized palygorskite adsorbents with high adsorption capacity for Pb²⁺ and reactive dyes[J].Applied Clay Science,2015,107:220-229.

[16] BERHANE T M,LEVY J,KREKELER M P S,et al.Adsorption of bisphenol A and ciprofloxacin by palygorskite-montmorillonite:effect of granule size,solution chemistry and temperature[J].Applied Clay Science,2016,132-133:518-527.

[17] MONTE M B M,MIDDEA A,PAIVA P R P,et al.Nutrient release by a Brazilian sedimentary zeolite[J].Anais da Academia Brasileira de Ciências,2009,81(4):641-653.

[18] RAHIMI M,MOBEDI H,BEHNAMGHADER A,et al.Fat-soluble vitamins release based on clinoptilolite zeolite as an oral drug delivery system[J].Letters in Drug Design & Discovery,2012,9(2):213-217.

[19] THE EUROPEAN COMMISSION.Commission regulation (EU) 575/2011 of 16 June 2011 on the catalogue of feed materials[J].Official Journal of the European Union,2011,159:25-65.

[20] ZHANG J M,LV Y F,TANG C H,et al.Effects of dietary supplementation with palygorskite on intestinal integrity in weaned piglets[J].Applied Clay Science,2013,86:185-189.

[21] TANG C H,WANG X Q,ZHANG J M.Effects of supplemental palygorskite instead of zinc oxide on growth performance,apparent nutrient digestibility and fecal zinc excretion in weaned piglets[J].Animal Science Journal,2014,85(4):435-439.

[22] LV Y F,TANG C H,WANG X Q,et al.Effects of dietary supplementation with palygorskite on nutrient utilization in weaned piglets[J].Livestock Science,2015,174:82-86.

[23] ZHANG L,YAN R,ZHANG R Q,et al.Effect of different levels of palygorskite inclusion on pellet quality,growth performance and nutrient utilization in broilers[J].Animal Feed Science and Technology,2017,223:73-81.

[24] CASTILLO M,MARTÍN-OR ÚE S M,TAYLOR-PICKARD J A,et al.Use of mannan-oligosaccharides and zinc chelate as growth promoters and diarrhea preventative in weaning pigs:effects on microbiota and gut function[J].Journal of Animal Science,2008,86(1):94-101.

[25] DUNSHEA F R.Sexual dimorphism in growth of sucking and growing pigs[J].Asian-Australasian Journal of Animal Sciences,2001,14(11):1610-1615.

[26] SPREEUWENBERG M A M,VERDONK J,GASKINS H R,et al.Small intestine epithelial barrier function is compromised in pigs with low feed intake at weaning[J].The Journal of Nutrition,2001,131(5):1520-1527.

[27] WANG C,ZHANG L G,SU W P,et al.Zinc oxide nanoparticles as a substitute for zinc oxide or colistin sulfate:Effects on growth,serum enzymes,zinc deposition,intestinal morphology and epithelial barrier in weaned piglets[J].PLoS One,2017,12(7):e0181136.

[28] 孟艳莉.凹凸棒石、蒙脱石及其复合物对断奶仔猪肠道的保护作用研究[D].硕士学位论文.北京:中国农业科学院,2011.

[29] 罗友文,周岩民,王恬.凹凸棒石粘土的生物学功能及其在动物生产上的应用[J].硅酸盐通报.2006,25(6):159-164.

[30] 肖金松,罗有文.凹凸棒石黏土在动物生产上的应用及其作用机制[J].江西农业学报,2008,20(10):97-99.

[31] 韩萌.纳米氧化锌对断奶仔猪肠道菌群平衡及黏膜免疫的影响[D].硕士学位论文.北京:中国农业大学,2017.

[32] LI Y,GUO W,HAN S S,et al.The evolution of the gut microbiota in the giant and the red pandas[J].Scientific Reports,2015,5:10185.

[33] KATOULI M,MELIN L,JENSEN-WAERN M,et al.The effect of zinc oxide supplementation on the stability of the intestinal flora with special reference to composition of coliforms in weaned pigs[J].Journal of Applied Microbiology,1999,87(4):564-573.

[34] 红玮,王贺,童春晖.具有药用前景的天然矿物——凹凸棒石[J].药学进展,2005,29(1):43-45.

[35] ROUSSEL A J,Jr,BRUMBAUGH G W.Treatment of diarrhea of neonatal calves[J].Veterinary Clinics of North America:Food Animal Practice,1991,7(3):713-728.

[36] ARABI F,IMANDAR M,NEGAHDARY M,et al.Investigation anti-bacterial effect of zinc oxide nanoparticles upon life of Listeria monocytogenes[J].Annals of Biological Research,2012,3(7):3679-3685.

[37] 梁晓维,李发弟,张军民,等.蒙脱石和凹凸棒石对霉菌毒素吸附性能的研究[J].中国畜牧兽医,2014,41(11):133-138.

[38] 黄强,徐稳,王恬,等.日粮补充亮氨酸对超早期断奶宫内发育迟缓仔猪内源消化酶活性及胰腺抗氧化能力的影响[J].南京农业大学学报,2017,40(1):123-129.

[39] ZIMMERMANN R,STRAUSS J G,HAEMMERLE G,et al.Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase[J].Science,2004,306(5700):1383-1386.

[40] DUKES H H.The physiology of domestic animals[M].New York:Comstock Publishing Associates,1955.

[41] 徐奇友,刘立波,侯奉雨,等.纳米氧化锌对肉仔鸡血清生化指标的影响[J].动物营养学报,2007,19(1):76-80.

[42] TOTH P P,DAVIDSON M H.Therapeutic interventions targeted at the augmentation of reverse cholesterol transport[J].Current Opinion in Cardiology,2004,19(4):374-379.

[43] 王彬,刘路杰,祝佳,等.纳米氧化锌对断奶仔猪生长性能、血清免疫和生化指标的影响[J].动物营养学报,2016,28(11):3626-3633.

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