Effects of Pasteurized &beta;-Lactam Antibiotic Milk on Growth, Development and Serum Immune Parameters of Calves

XIN Xiaoyue, QU Yongli, YUAN Xue, GAO Yan, WANG Lu, ZHANG Shuai, YIN Shuxin

doi:10.3969/j.issn.1006-267x.2018.04.046

Chinese Journal of Animal Nutrition >

2018 , Vol. 30 >Issue 4: 1603 - 1610

DOI: https://doi.org/10.3969/j.issn.1006-267x.2018.04.046

Molecular Nutrition

Effects of Pasteurized β-Lactam Antibiotic Milk on Growth, Development and Serum Immune Parameters of Calves

Expand

College of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China

Received date: 2017-09-10

Online published: 2018-04-03

Fold

Abstract

This study was performed to investigate the effects of feeding pasteurized β-lactam antibiotic milk on growth, development and serum immune parameters of calves. Eighteen healthy 3-day-old Holstein male calves with similar body weight was randomly divided into 2 groups with 9 calves per group. Calves in control group were fed β-lactam antibiotic milk, and those in experimental group were fed pasteurized β-lactam antibiotic milk. The pasteurization condition was as follows:milk was heated at 63 to 65℃ for 30 min. Calves were weaned at 60 days of age, and the experiment period was 180 days. The results were as follows:1) compared with β-lactam antibiotic milk, the counts of total bacteria, Escherichia coli and Salmonella in pasteurized β-lactam antibiotic milk were significantly decreased (P<0.01); 2)compared with control group, average daily gain of calves during 3 to 60 days of age of experimental group was significantly higher (P<0.05); 3) compared with control group, serum immunoglobulin A (IgA) content at 30 days of age, and serum immunoglobulin M (IgM) content at 15 and 30 days of age was significantly lower (P<0.05), serum immunoglobulin G (IgG) content at 30 days of age was significantly decreased (P<0.05), serum interleukin 1β (IL-1β) content at 15 days of age was significantly increased (P<0.05), and serum interleukin 6 (IL-6) content at 7 days of age was significantly decreased (P<0.05). The results prove that the feeding of pasteurized β-lactam antibiotic milk can improve growth and development of lactating calves, and has effects on immune system, however, the conclusions of promotion or inhibition can not be made.

Key words： Holstein male calve; antibiotic milk; pasteurisation; growth and development; serum immune parameter

Cite this article

XIN Xiaoyue, QU Yongli, YUAN Xue, GAO Yan, WANG Lu, ZHANG Shuai, YIN Shuxin . Effects of Pasteurized β-Lactam Antibiotic Milk on Growth, Development and Serum Immune Parameters of Calves[J]. Chinese Journal of Animal Nutrition, 2018 , 30(4) : 1603 -1610 . DOI: 10.3969/j.issn.1006-267x.2018.04.046

References

[1] 张致平.β-内酰胺类抗生素研究的进展(Ⅰ)[J].中国抗生素杂志,2000,25(2):81-86.

[2] SCHAEREN W.Fakten zur Verfu tterung von antibiotikahaltiger Milch an Kalber[J].ALP Forum,2006,35,1-2.

[3] Milcherzeugung und-verwendung[M].Wiesbaden,Germany:Statistisches Bundesamt.2008.

[4] 顾佳升,张书义,韩荣伟.巴氏杀菌工艺是引领我国奶业走出困境的核心技术[J].中国奶牛,2016(8):60-65.

[5] 国家质量技术监督局.GB 5408.1-1999巴氏杀菌乳[S].北京:中国标准出版社,1999.

[6] 姚新奎,车驰.巴氏杀菌乳营养价值及发展前景[J].新疆畜牧业,2010(6):10-13.

[7] 刘根涛,卜登攀,赵连生,等.巴氏初乳对犊牛生长性能及胃肠道发育的影响[J].中国畜牧兽医,2017,44(6):1714-1719.

[8] 韩云胜,曲永利,吴健豪,等.含β-内酰胺类药物有抗奶对犊牛生长发育和血液免疫指标的影响[J].中国畜牧兽医,2017,44(7):2009-2015.

[9] JORGENSEN M,HOFFMAN P,NYTES A.Efficacy of on-farm pasteurized waste milk systems on upper Midwest dairy and custom calf rearing operations[J/OL].Professional Animal Scientist,2005.http://www.extension.umn.edu/agriculture/dairy/beef/on-farm-pasteurized-waste-milk-systems.pdf

[10] 臧长江,王加启,杨永新,等.热处理牛乳中乳蛋白变化的比较蛋白质组学的研究[J].畜牧兽医学报,2012,43(11):1754-1759.

[11] WELPER R D,FREEMAN A E.Genetic parameters for yield traits of holsteins,including lactose and somatic cell score[J].Journal of Dairy Science,1992,75(5):1342-1348.

[12] 朱正鹏,单安山,薛艳林,等.牛乳体细胞数对牛奶品质的影响[J].中国畜牧杂志,2006,42(13):47-50.

[13] SHARMA N,SINGH N K,BHADWAL M S.Relationship of somatic cell count and mastitis:an overview[J].Asian-Australasian Journal of Animal Sciences,2011,24(3):429-438.

[14] CECILIANI F,CERON J J,ECKERSALL P D,et al.Acute phase proteins in ruminants[J].Journal of Proteomics,2012,75(14):4207-4231.

[15] 李龙柱,张富新,葛萍,等.巴氏杀菌对原料羊乳卫生质量的影响[J].食品工业科技,2014,35(1):223-226.

[16] JORGENSEN M A,HOFFMAN P C,NYTES A J.A field survey of on-farm milk pasteurization efficacy[J].Professional Animal Scientist,2006,22(6):472-476.

[17] AUST V,KNAPPSTEIN K,KUNZ H J,et al.Feeding untreated and pasteurized waste milk and bulk milk to calves:effects on calf performance,health status and antibiotic resistance of faecal bacteria[J].Journal of Animal Physiology & Animal Nutrition,2013,97(6):1091-1103.

[18] 宋健,韩盈利,周波,等.规模奶牛场哺乳犊牛饲喂巴氏消毒奶的效果观察[J].新疆畜牧业,2013(10):39-40.

[19] STROET D L, DÍAZ J A C,STALDER K J,et al.Association of calf growth traits with production characteristics in dairy cattle[J].Journal of Dairy Science,2016,99(10):8347-8355.

[20] 莫放.养牛生产学[M].2版.北京:中国农业大学出版社,2010.

[21] HILL S R,KNOWLTON K F,DANIELS K M,et al.Effects of milk replacer composition on growth,body composition,and nutrient excretion in preweaned holstein heifers[J].Journal of Dairy Science,2008,91(8):3145-3155.

[22] MCEWEN S A,FEDORKA-CRAY P J.Antimicrobial use and resistance in animals[J].Clinical Infectious Diseases,2002,34(Suppl.3):S93-S106.

[23] HORTON R E,VIDARSSON G.Antibodies and their receptors:different potential roles in mucosal defense[J].Frontiers in Immunology,2013,4:200.

[24] DANIELS K M,HILL S R,KNOWLTONK F,et al.Effects of milk replacer composition on selected blood metabolites and hormones in preweaned Holstein heifers[J].Journal of Dairy Science,2008,91(7):2628-2640.

[25] 陈庆华,王欣.冷藏温度及时间对巴氏杀菌乳品质的影响研究[J].食品科技,2009(1):84-87.

[26] ZOU Y,WANG Y J,DENG Y F,et al.Effects of feeding untreated,pasteurized and acidified waste milk and bunk tank milk on the performance,serum metabolic profiles,immunity,and intestinal development in Holstein calves[J].Journal of Animal Science and Biotechnology,2017,8(1):53.

[27] KIDD P.Th1/Th2 balance:the hypothesis,its limitations,and implications for health and disease[J].Alternative Medicine Review,2003,8(3):223-246.

[28] 金宁一,王宏伟,方厚华,等.中国流行株HIV-1gag-gp120与IL-2/IL-6共表达核酸疫苗质粒的构建和实验免疫研究[J].中国预防兽医学报,2001,23(1):1-51.

[29] LOWENTHAL J W,O'NEIL T E,BROADWAY M,et al.Coadministration of IFN-γ enhances antibody responses in chickens[J].Journal of Interferon & Cytokine Research the Official Journal of the International Society for Interferon & Cytokine Research,1998,18(8):617-622.

Options

Outlines

模态框（Modal）标题

Abstract

Cite this article

References