Effects of Dietary Sanguinarine on Growth Performance, Intestinal Mucosal Morphology and Immune Function of Small Intestinal Mucosa of Weaned Piglets

CHEN Jiashun, KANG Baoju, ZENG Jianguo, HU Haibo, ZHAO Yurong, CHEN Liu, YAO Kang, FU Chenxing

doi:10.3969/j.issn.1006-267x.2018.05.027

2018 , Vol. 30 >Issue 5: 1845 - 1853

DOI: https://doi.org/10.3969/j.issn.1006-267x.2018.05.027

Molecular Nutrition

Effects of Dietary Sanguinarine on Growth Performance, Intestinal Mucosal Morphology and Immune Function of Small Intestinal Mucosa of Weaned Piglets

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1. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China;
2. Hunan Provincial Engineering Research Center for Healthy Breeding of Livestock and Poultry, Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;
3. Hunan Collaborative Innovation Center for Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha 410128, China;
4. Hunan Micolt Bioresource Co., Ltd., Changsha 410128, China;
5. Bureau of Animal Husbandry and Veterinary and Aquaculture in Liuyang City, Liuyang 410300, China

Received date: 2017-10-18

Online published: 2018-05-06

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Abstract

This experiment was conducted to study the effects of dietary sanguinarine (SAN) on growth performance, intestinal mucosal morphology and immune function of small intestinal mucosa of weaned piglets. Thirty-six "Duroc×Landrace×Yorkshire" hybrid pigs with initial weight of (6.55±0.18) kg were randomly divided into three groups with twelve replicates per group and one pig per replicate according to similar body weight and the same ratio of gender. The pigs in the control group were fed a basal diet, those in antibiotic group were fed the basal diet supplemented with 75 mg/kg chlortetracycline, and the others in SAN group were fed the basal diet supplemented with 50 mg/kg sanguinarine. The experiment lasted for 21 days. The results showed as follows:1) compared with the control group, the average daily gain and the average daily feed intake were significantly increased (P<0.05), and the ratio of feed to gain and diarrhea rate were significantly decreased (P<0.05) in SAN group and antibiotic group. But there were no significant differences in above growth performance indices between SAN group and antibiotic group (P>0.05). 2) Compared with the control group, the villus height and the ratio of villus height to crypt depth (V/C) of duodenum and jejunum were significantly increased (P<0.05 or P<0.01) in SAN group and antibiotic group, and no significant differences were found in above indices between SAN group and antibiotic group (P>0.05), while the villus height and V/C of ileum in SAN group were significantly higher than those in the other two groups (P<0.05). 3) Compared with the control group, the contents of immunoglobulin A (IgA), immunoglobulin G (IgG) and immunoglobulin M (IgM) in duodenum, jejunum and ileum in SAN group and antibiotic group were significantly increased (P<0.05 or P<0.01) except the IgG content in duodenum mucosa and the IgM content in jejunum mucosa. But no significant differences were found in above indices between SAN group and antibiotic group (P>0.05). In conclusion, dietary sanguinarine with the same effects of antibiotic can improve intestinal mucosal morphology, and increase small intestinal mucosal immune function, consequently improve the growth performance of weaned piglets.

Key words： sanguinarine; weaned piglets; growth performance; intestinal mucosal morphology; immunoglobulin

Cite this article

CHEN Jiashun, KANG Baoju, ZENG Jianguo, HU Haibo, ZHAO Yurong, CHEN Liu, YAO Kang, FU Chenxing . Effects of Dietary Sanguinarine on Growth Performance, Intestinal Mucosal Morphology and Immune Function of Small Intestinal Mucosa of Weaned Piglets[J]. Chinese Journal of Animal Nutrition, 2018 , 30(5) : 1845 -1853 . DOI: 10.3969/j.issn.1006-267x.2018.05.027

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