Molecular Nutrition

Taurine: Physiological Function and Application in Pig Production

Expand
  • College of Animal Science and Technology, Hunan Agricultural University, Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China

Received date: 2017-12-08

  Online published: 2018-06-20

Abstract

Taurine is a kind of free amino acid presents in animal body and has the functions of anti-oxidation, enhancing immunity and anti-apoptosis et al. As a feed additive, taurine has attracted attention in livestock production, which has the effects of improving production performance, breeding performance and reducing stress injury. This article describes the physiological function of taurine and its mechanism of action, and summarizes the recent application of taurine in pig production, in order to provide a reference for the better application of taurine in pig production.

Cite this article

HAO Zhongyu, YANG Jiaming, XIAO Kequan, YANG Tai, LI Xue, GAO Fengxian . Taurine: Physiological Function and Application in Pig Production[J]. Chinese Journal of Animal Nutrition, 2018 , 30(6) : 2050 -2056 . DOI: 10.3969/j.issn.1006-267x.2018.06.005

References

[1] HUXTABLE R J.Physiological action of taurine[J].Physiological Reviews,1992,72(1):101-163.  

[2] 刘洋景.牛磺酸对笼养后备蛋鸭的作用研究[D].硕士学位论文.哈尔滨:东北农业大学,2012.

[3] TIEDEMANN F,GMELIN L.Einige neue bestandtheile der galle des ochsen[J].Annalen der Physik,2010,85(2):326-337.

[4] HAYES K C,STURMAN J A.Taurine in metabolism[J].Annual Review of Nutrition,1981,1(1):401-425.  

[5] ZHANG X L,WANG X H,JING Z,et al.Effects of taurine on alterations of neurobehavior and neurodevelopment key proteins expression in infant rats by exposure to hexabromocyclododecane[C]//LEE D H,SCHAFFER S W,PARK E,et al.Advances in Experimental Medicine and Biology.Dordrecht:Springer,2017:119-130.

[6] ZHANG X,TU S,WANG Y,et al.Mechanism of taurine-induced apoptosis in human colon cancer cells[J].Acta Biochimica et Biophysica Sinica,2014,46(4):261-272.  

[7] 宋玉美,贺瑜,梁柏莹,等.牛磺酸对裸鼠乳腺癌模型肿瘤生长的影响及其机制[J].中国癌症防治杂志,2016,8(5):269-272.

[8] THAEOMOR A,TEANGPHUCK P,CHAISAKUL J,et al.Perinatal taurine supplementation prevents metabolic and cardiovascular effects of maternal diabetes in adult rat offspring[C]//LEE D H, SCHAFFER S W, PARK E,et al.Advances in experimental medicine and biology.Dordrecht:Springer,2017,975:295.

[9] 武晓红,曹力,徐廷生,等.牛磺酸对产蛋后期蛋鸡生产性能及蛋壳品质的影响[J].湖北农业科学,2016,55(10):2600-2602.

[10] 王学习,周铭文,黄岩,等.饲料牛磺酸水平对不同生长阶段斜带石斑鱼幼鱼生长性能和体成分的影响[J].动物营养学报,2017,29(5):1810-1820.

[11] 任双.牛磺酸缓解大鼠慢性应激的作用研究[D].硕士学位论文.哈尔滨:沈阳农业大学,2016.

[12] 张小龙.牛磺酸对早期断奶仔猪生长性能和肠道发育的影响及机制[D].硕士学位论文.重庆:西南大学,2015.

[13] NAKAMURA-KUSAKABE I,NAGASAKI T,KINJO A,et al.Effect of sulfide,osmotic,and thermal stresses on taurine transporter mRNA levels in the gills of the hydrothermal vent-specific mussel Bathymodiolus septemdierum[J].Comparative Biochemistry & Physiology Part A:Molecular & Integrative Physiology,2016,191:74-79.

[14] HELLER-STILB B,VAN ROEYEN C,RASCHER K,et al.Disruption of the Taurine transporter gene (Taut) leads to retinal degeneration in mice[J].FASEB Journal,2002,16(2):231-233.  

[15] ITO T,OISHI S,TAKAI M,et al.Cardiac and skeletal muscle abnormality in Taurine transporter-knockout mice[J].Journal of Biomedical Science,2010,17(Suppl.1):1-5.

[16] 王继强,龙强,李爱琴,等.牛磺酸的营养价值及其在家禽日粮上的应用[J].家禽科学,2010(4):43-46.

[17] 常林,赵晶,徐建兴,等.牛磺酸拮抗同型半胱氨酸诱导的线粒体呼吸链自由基生成和同型半胱氨酸抑制线粒体牛磺酸转运体[J].中国病理生理杂志,2004,20(7):1126-1133.

[18] 张晓丹,蔡瑞雪,吕高照,等.牛磺酸对阿霉素所致大鼠心肌线粒体损伤的影响[J].中成药,2011,33(2):218-221.

[19] 张星光,依桂艳,吕肖锋,等.牛磺酸对大乳鼠心肌细胞抗氧化作用的荧光免疫化学分析[J].分析化学,2012,40(6):955-959.

[20] 白剑,肖漓,韩永,等.牛磺酸对肝纤维化模型小鼠肝组织超氧化物歧化酶和丙二醛的影响[J].中国组织工程研究,2015,19(27):4379-4383.

[21] 吴志红,马燕芬,赵磊,等.Nrf2-ARE信号通路在机体氧化应激损伤中的作用及与其他信号通路的关系[J].畜牧与饲料科学,2016,37(3):42-48.

[22] 孔媛.牛磺酸保护三氧化二砷引起的子代大鼠胰腺自噬性损伤的实验研究[D].硕士学位论文.大连:大连医科大学,2017.

[23] 李乐慧,徐兆发,奉姝,等.牛磺酸对甲基汞染毒大鼠脑皮质Nrf2及HO-1、γ-GCSGpx-1表达的影响[J].中国工业医学杂志,2013(3):163-166.

[24] 梁栋.牛磺酸对高糖诱导的内皮细胞凋亡的影响及其机制[D].硕士学位论文.太原:山西医科大学,2014.

[25] 乔梦,刘萍,任晓菲,等.牛磺酸对铝染毒大鼠脑组织抗氧化系统的保护作用[J].环境与健康杂志,2014,31(5):406-409.

[26] ZHOU J P,LI Y,YAN G Y,et al.Protective role of Taurine against morphine-induced neurotoxicity in C6 cells via inhibition of oxidative stress[J].Neurotoxicity Research,2011,20(4):334-342.  

[27] 张茗晰,张萌,Ripps H,等.牛磺酸的研究进展[J].黑龙江畜牧兽医,2015(7):76-78.

[28] VESCE S,KIRK L,NICHOLLS D G.Relationships between superoxide levels and delayed calcium deregulation in cultured cerebellar granule cells exposed continuously to glutamate[J].Journal of Neurochemistry,2004,90(3):683-693.  

[29] HAMAGUCHI T,AZUMA J,SCHAFFER S.Interaction of Taurine with methionine:inhibition of myocardial phospholipid methyltransferase[J].Journal of Cardiovascular Pharmacology,1991,18(2):224-230.  

[30] 龚慧,万慧芳,王美凤,等.牛磺酸对肾NRK-52E细胞缺氧/复氧损伤的保护及初步机制[J].中国药理学通报,2011,27(7):961-965.

[31] 刘阳,王李瑶,张庆华,等.活化Caspase 9在牛磺酸保护神经细胞中的保护作用[J].医学研究生学报,2014(8):793-796.

[32] LIU J,WANG X F,LIU Y,et al.Antenatal Taurine reduces cerebral cell apoptosis in fetal rats with intrauterine growth restriction[J].Neural Regeneration Research,2013,8(23):2190-2197.

[33] ITO Y,PANDEY P,MISHRA N,et al.Targeting of the c-Abl tyrosine kinase to mitochondria in endoplasmic reticulum stress-induced apoptosis[J].Molecular and Cellular Biology,2001,21(18):6233-6242.  

[34] CHAO C C,CHAN P,KUO C S,et al.Protection of differentiated neuronal NG108-15 cells from P2X7 receptor-mediated toxicity by Taurine[J].Pharmacological Reports,2014,66(4):576-584.  

[35] 成兰云,门秀丽,张连元,等.内质网应激诱导的细胞凋亡在大鼠肢体缺血再灌注后肺损伤中的作用及牛磺酸的影响[J].中国病理生理杂志,2010,26(9):1776-1780.

[36] MA Y J,BREWER J W,DIEHL J A,et al.Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response[J].Journal of Molecular Biology,2002,318(5):1351-1365.  

[37] 门秀丽,张连元,杨全会,等.大鼠肢体缺血再灌注后肺组织Bax基因表达上调[J].基础医学与临床,2005,25(3):261-264.

[38] 浦践一,赵琪,门秀丽,等.牛磺酸对大鼠肢体骨骼肌缺血再灌注后内质网应激反应的影响[J].中日友好医院学报,2010,24(4):223-225.

[39] 沈海涛,吴娜,王煜,等.牛磺酸对百草枯中毒大鼠肾损伤的作用及机制研究[J].中国病理生理杂志,2017,33(7):1295-1300.

[40] 吴彤,单颖.牛磺酸对心肌缺血再灌注大鼠模型心肌损伤的保护作用[J].中国临床药理学与治疗学,2016,21(8):884-889.

[41] 叶云,李筱俊,李子广,等.牛磺酸以p38丝裂原活化蛋白激酶依赖方式减轻大鼠心肌缺血再灌注损伤[J].实用医学杂志,2009,25(12):1923-1925.

[42] 邢雁霞,刘宏,刘斌钰,等.牛磺酸对大鼠急性肺损伤的保护作用与分子机制[J].长治医学院学报,2014(4):245-248.

[43] 田莉莉,李丽.牛磺酸对肉仔鸡生产性能和消化功能的影响[J].饲料研究,2012(3):54-55.

[44] 李万军.牛磺酸对肉鸡饲粮养分利用率、免疫器官发育及屠宰性能的影响研究[J].中国农学通报,2012,28(23):6-10.

[45] 王中华,黄修奇.牛磺酸对肉鸡生产性能和免疫器官指数的影响[J].中国家禽,2011,33(15):68-69.

[46] 王玉婷.长白猪组织中牛磺酸合成关键酶及转运体的表达研究[D].硕士学位论文.沈阳:沈阳农业大学,2016.

[47] 白剑,肖漓,韩勇,等.牛磺酸对四氯化碳诱导小鼠肝纤维化模型中白介素2的影响[J].解放军医药杂志,2015,27(7):24-27.

[48] JIMÉNEZ F D,LAMKANFI M.Inflammatory caspases:key regulators of inflammation and cell death[J].Biological Chemistry,2015,396(3):193-203.

[49] 郭杰,王蓓,戎瑞雪,等.牛磺酸对顺铂所致H22荷瘤小鼠免疫器官及淋巴细胞损伤的保护作用[J].食品科学,2015,36(5):200-204.

[50] 车向荣,陈娟娟,岳文斌,等.甘氨酰谷氨酰胺和牛磺酸对早期断奶仔猪肠黏膜形态与免疫功能的影响[C]//中国畜牧兽医学会动物营养学分会第十次学术研讨会论文集.杭州:中国畜牧兽医学会,2008.

[51] 范红艳,任旷,顾饶胜,等.牛磺酸对于心肌炎及其继发纤维化的抑制作用[J].中国药学杂志,2010,45(13):997-1001.

[52] 费东亮,王宏军,苏禹刚,等.牛磺酸对热应激肉鸡肠道SIgA和细胞因子的影响[J].饲料研究,2014(13):33-35,63.

[53] 张建斌,车向荣,陈娟娟.甘氨酰谷氨酰胺和牛磺酸对断奶仔猪肠道吸收功能的影响[J].中国畜牧兽医,2010,37(8):20-22.

[54] 张建斌,车向荣,陈娟娟.谷氨酰胺和牛磺酸对仔猪肠黏膜形态的影响[J].饲料研究,2011(8):50-52.

[55] 黄仁术,彭志玲.日粮类型及牛磺酸添加对断奶仔猪生长性能的影响[J].粮食与饲料工业,2008(9):44-45.

[56] 黄仁术,彭志玲,凌明亮.牛磺酸在断奶仔猪高动物蛋白日粮中的添加效应[J].中兽医医药杂志,2008,27(6):30-32.

[57] 陈松,孙苗.饲料添加剂对仔猪生产性能及消化吸收功能的影响[J].黑龙江畜牧兽医,2014(20):39-40.

[58] 陈松,孙苗.牛磺酸预防断奶仔猪腹泻的研究[J].猪业观察,2013(11):58.

[59] LIU Y,MAO X B,YU B,et al.Excessive dietary taurine supplementation reduces growth performance,liver and intestinal health of weaned pigs[J].Livestock Science,2014,168:109-119.

[60] 陈钊,王明江,兰家暖,等.牛磺酸对夏季母猪哺乳期生产性能影响的研究[J].广西畜牧兽医,2017,33(5):252-253.

[61] 李方方,蒋超群,朱宇旌,等.牛磺酸对种公猪精液品质、血清激素含量及精浆抗氧化能力的影响[J].动物营养学报,2016,28(4):1122-1128.

[62] 刘琦.不同精子质膜保护剂对猪精液常温保存效果的影响[D].硕士学位论文.杨凌:西北农林科技大学,2015.

[63] SCHAFFER S W,AZUMA J,MOZAFFARI M.Role of antioxidant activity of Taurine in diabetes[J].Canadian Journal of Physiology and Pharmacology,2009,87(87):91-99.

[64] 王胜林,林映才,郑黎,等.抗热应激剂对肥育猪血清生化指标的影响[J].中国畜牧杂志,2003,39(1):11-12.

[65] 刘法东.高温高湿环境对自发性高血压大鼠胸主动脉损伤的影响及其机制研究[D].硕士学位论文.银川:宁夏医科大学,2016.

[66] 贾丹,昝君兰,赵宏,等.热应激对猪小肠组织形态和细胞凋亡的影响[J].北京农学院学报,2012,27(1):36-38.

[67] 王洋,董红艳,刘莹,等.热应激对鹅小肠形态结构及肥大细胞影响的研究[J].中国兽医杂志,2015,51(5):12-14,18.
Outlines

/