This experiment was conducted to investigate the effects of supplementation with compound enzymes and probiotics on sorghum diets on growth performance, serum antioxidant indexes and intestinal morphology of Liangfenghua broilers. A total of 900 healthy one-day-old Liangfenghua male broilers with similar body weight were randomly selected and allocated to 5 groups with 6 replicates per group and 30 broilers per replicate. Broilers in the control group were fed a basal diet, and others in the experimental groups were fed sorghum diet (sorghum group), sorghum diet+compound enzyme (sorghum+compound enzyme group), sorghum diet+probiotics (sorghum+probiotics group) and sorghum diet+compound enzyme diet+probiotics (sorghum+compound enzyme+probiotics group), respectively. The experiment lasted for 56 days, and divided into two stages of early stage (1 to 28 days of age) and later stage (29 to 56 days of age). At the end of experiment, the growth performance, serum antioxidant indexes and intestinal morphology of broilers were evaluated. The results showed as follows:1) at the early stage, the average daily feed intake (ADFI) and feed to gain ratio (F/G) of broilers in experimental groups were significantly lower than those in control group (P<0.05). At the later stage and the whole stage (1 to 56 days of age), the ADFI and the average daily gain (ADG) of broilers in experimental groups (except sorghum+compound enzyme group) were significantly lower than those in control group (P<0.05). 2) Compared with the control group, the serum total superoxide dismutase (T-SOD) activity of broilers at 28 days of age in sorghum group was significantly decreased (P<0.05), and no significant difference was observed among the rest groups (P>0.05). At 56 days of age, there were no significant differences on serum antioxidant indexes of broilers among all groups (P>0.05). 3) At 28 days of age, the villus height and villus height/crypt depth (V/C) value in duodenum of broilers experimental groups (except sorghum group) were significantly higher than those in control group (P<0.05). At 56 days of age, there were no significant differences on villus height, villus height and V/C value in duodenum, jejunum and ileum of broilers among all groups (P>0.05). In conclusion, sorghum instead of corn in the diet significantly reduce the growth performance of Liangfenghua broilers, and added compound enzyme in the sorghum diet can obtaine the similar growth performance compared the control group, the sorghum diet supplemented with compound enzyme and probiotics have no adverse effects on intestinal morphologic structure and serum antioxidant indexes.