Molecular Nutrition

Effects of Clostridium butyricum on Growth Performance, Intestinal Structure and Immune Function of Weaned Piglets

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  • 1. Key Laboratory of Feed and Animal Nutrition of Zhejiang Province, Key Laboratory of Animal Nutrition and Feed in East China, Ministry of Agriculture, Key Laboratory of Animal Molecular Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China;
    2. College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China;
    3. Hubei Green Snow Biological Industry Co., Ltd., Xianning 437110, China

Received date: 2017-12-25

  Online published: 2018-07-20

Abstract

This study was conducted to investigate the effects of dietary Clostridium butyricum on growth performance, intestinal structure and immune function of weaned piglets. Three hundred and sixty (25±1) days of age healthy "Duroc×Landrace×Yorkshire" hybrid piglets with the body weight of (6.24±0.32) kg were randomly divided into 5 groups with 4 replicates per group and 18 piglets per replicate. Piglets in control group were fed a basal diet, and those in experimental groups were fed the basal diet supplemented with 250, 500, 1 000 and 2 000 mg/kg Clostridium butyricum, respectively. The experiment lasted for 30 days. The results showed as follows:1) the average daily feed intake (ADFI) of weaned piglets in 250 and 1 000 mg/kg Clostridium butyricum supplemented groups was significantly lower than that in control group (P<0.05). Compared with control group, diarrhea rate in 250 and 500 mg/kg Clostridium butyricum supplemented groups was significantly decreased by 40.99% and 44.32% (P<0.05), respectively. 2) Compared with control group, villous height of jejunum of weaned piglets in Clostridium butyricum supplemented groups was significantly increased by 32.23%, 35.71%, 33.59% and 47.36% (P<0.05), respectively; and the ratio of villous height to crypt depth of jejunum was significantly increased by 47.24% (P<0.01), 48.03% (P<0.01), 19.69% (P<0.05) and 22.83% (P<0.05), respectively. 3) Dietary Clostridium butyricum significantly increased the contents of immunoglobulin A (IgA) and immunoglobulin G (IgG) in serum of weaned piglets (P<0.05), and there were no significant differences in the contents of immunoglobulin M (IgM), complement 3 (C3) and complement 4 (C4) in serum among all groups (P>0.05). The results indicate that diet supplemented with 250 to 500 mg/kg Clostridium butyricum can improve intestinal structure and immune function of weaned piglets from 25 to 55 days of age.

Cite this article

ZHENG Youxiu, WANG Chao, ZOU Xiaoting, WANG Li, LU Jianjun . Effects of Clostridium butyricum on Growth Performance, Intestinal Structure and Immune Function of Weaned Piglets[J]. Chinese Journal of Animal Nutrition, 2018 , 30(7) : 2683 -2689 . DOI: 10.3969/j.issn.1006-267x.2018.07.028

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