Evaluation of Biological Safety of Pyrroloquinoline Quinone Disodium Salt for Broilers

SUN Guangming, DONG Xueyu, LIAO Xiudong, ZHANG Liyang, GUO Yanli, LYU Lin, LUO Xugang

doi:10.3969/j.issn.1006-267x.2018.07.045

Chinese Journal of Animal Nutrition >

2018 , Vol. 30 >Issue 7: 2831 - 2840

DOI: https://doi.org/10.3969/j.issn.1006-267x.2018.07.045

Molecular Nutrition

Evaluation of Biological Safety of Pyrroloquinoline Quinone Disodium Salt for Broilers

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1. College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China;
2. Mineral Nutrition Research Division, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received date: 2017-12-29

Online published: 2018-07-20

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Abstract

This experiment was conducted to investigate the effects of dietary pyrroloquinoline quinone disodium salt (PQQ·Na₂) supplemental level on growth performance, blood physiological parameters, plasma biochemical parameters, organ development and histopathological changes of Arbor Acres (AA) broilers, so as to evaluate the biological safety of PQQ·Na₂ for broilers. A total of 240 one-day-old AA broilers were randomly allocated to four groups with six replicates per group and ten broilers per replicate (half male and half female) using a completely randomized design. Birds were fed the diets supplemented with 0, 0.3, 1.5 or 3.0 mg/kg PQQ·Na₂ for an experimental duration of 49 days. The results indicated that dietary PQQ·Na₂ supplemental levels had no significant effects on the growth performance, blood physiological parameters and plasma biochemical parameters of broilers at 21 and 49 days of age, and organ indices of broilers at 49 days of age(P>0.05), as well as the histopathological changes of major organs. Therefore, the maximum of effective supplemental level of PQQ·Na₂ in the corn-soybean meal diet is recommended to be 0.3 mg/kg, the 10 times of appropriate PQQ·Na₂ supplemental level which is safe for broilers.

Key words： pyrroloquinoline quinone disodium salt; biological safety evaluation; broilers

Cite this article

SUN Guangming, DONG Xueyu, LIAO Xiudong, ZHANG Liyang, GUO Yanli, LYU Lin, LUO Xugang . Evaluation of Biological Safety of Pyrroloquinoline Quinone Disodium Salt for Broilers[J]. Chinese Journal of Animal Nutrition, 2018 , 30(7) : 2831 -2840 . DOI: 10.3969/j.issn.1006-267x.2018.07.045

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