Effects of Different Types of Vitamin D3 on Milk Production, Blood Indices, Calcium and Phosphorus Metabolism of Dairy Cows

LU Na, ZONG Xuexing, WANG Yajing, SHAO Wei, YU Xiong, LI Shengli

doi:10.3969/j.issn.1006-267x.2018.08.016

2018 , Vol. 30 >Issue 8: 2997 - 3004

DOI: https://doi.org/10.3969/j.issn.1006-267x.2018.08.016

Molecular Nutrition

Effects of Different Types of Vitamin D₃ on Milk Production, Blood Indices, Calcium and Phosphorus Metabolism of Dairy Cows

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1. College of Animal Science and Technology, Xinjiang Agricultural University, Urumqi 830052, China;
2. Beijing Engineering Technology Research Center of Raw Milk Quality and Safety Control, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China;
3. Inner Mongolia Mengniu Dairy(Group) Co., Ltd., Hohhot 011500, China

Received date: 2018-01-26

Online published: 2018-08-18

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Abstract

This experiment was conducted to investigate the effects of different types of vitamin D₃[vitamin D₃ and 25-(OH) D₃] on milk production, blood indices, calcium and phosphorus metabolism of lactating Holstein dairy cows. Forty-five healthy lactating Holstein dairy cows with similar milk yield, parity, milk composition and lactation days were randomly assigned into 3 groups with 15 replicates per group and 1 cow per replicate. Cows in the control group were fed a basal diet, cows in the trial group Ⅰ were fed the basal diet supplemented with 25 000 IU/(head·d) vitamin D₃, and cows in the trial group Ⅱ were fed the basal diet supplemented with 60 mg/(head·d) 25-(OH) D₃. The pre-experimental period lasted for 10 days, and the experimental period lasted for 60 days. The results showed as follows:1) the contents of milk protein, milk calcium and milk zinc of trial groups Ⅰ and Ⅱ were significantly higher than those of control group (P<0.05), the milk somatic cell count (SCC) of trial groups Ⅰ and Ⅱ was significantly lower than that of control group (P<0.05), there were no significant differences on dry matter intake (DMI), milk yield and other milk composition contents among 3 groups (P>0.05). 2) The blood osteocalcin content of trial groups Ⅰ and Ⅱ was significantly higher than that of control group (P<0.05), while the blood bio-marker of bone resorption content of trial groups Ⅰ and Ⅱ was significantly lower than that of control group (P<0.05); there were no significant differences on the contents of parathyroid hormone, calcium, phosphorus and magnesium and activity of alkaline phosphatase in blood among 3 groups (P>0.05). 3) The milk calcium output of trial groups Ⅰ and Ⅱ was significantly higher than that of control group (P<0.05), while the feces calcium output was significantly lower than that of control group (P<0.05), the deposition and apparent digestibility of calcium and phosphorus of trial groups Ⅰ and Ⅱ were significantly higher than those of control group (P<0.05). In conclusion, dietary vitamin D₃ and 25-(OH) D₃ can significantly improve the deposition and apparent digestibility of calcium and phosphorus, and significantly improve the contents of milk protein, milk calcium and milk zinc, meanwhile significantly reduce SCC, improve the milk quality, thus improve the production performance of dairy cows.

Key words： vitamin D₃; 25-(OH) D₃; lactating dairy cows; calcium and phosphorus metabolism

Cite this article

LU Na, ZONG Xuexing, WANG Yajing, SHAO Wei, YU Xiong, LI Shengli . Effects of Different Types of Vitamin D₃ on Milk Production, Blood Indices, Calcium and Phosphorus Metabolism of Dairy Cows[J]. Chinese Journal of Animal Nutrition, 2018 , 30(8) : 2997 -3004 . DOI: 10.3969/j.issn.1006-267x.2018.08.016

References

[1] HORST R L,GOFF J P,REINHARDT T A.Calcium and vitamin D metabolism in the dairy cow[J].Journal of Dairy Science,1994,77(7):1936-1951.

[2] GAST D R,HORST R L,JORGENSEN N A,et al.Potential use of 1,25-dihydroxycholecalciferol for prevention of parturient paresis[J].Journal of Dairy Science,1979,62(6):1009-1013.

[3] JONES G.Pharmacokinetics of vitamin D toxicity[J].The American Journal of Clinical Nutrition,2008,88(2):582S-586S.

[4] 廖波,张克英,丁雪梅,等.饲粮添加25-羟基维生素D₃对轮状病毒攻毒和未攻毒断奶仔猪血清和肠内容物抗体和细胞因子水平的影响[J].动物营养学报,2011,23(1):34-42.

[5] TAYLOR M S,KNOWLTON K F,MCGILLIARD M L,et al.Blood mineral,hormone,and osteocalcin responses of multiparous Jersey cows to an oral dose of 25-hydroxyvitamin D₃ or vitamin D₃ before parturition[J].Journal of Dairy Science,2008,91(6):2408-2416.

[6] 叶慧,郑玲玲,雷建平,等.25羟基维生素D₃和1α羟基维生素D₃代替维生素D₃对42-63日龄黄羽肉鸡生长性能、血清生化指标和胫骨发育的影响[J].动物营养学报,2013,25(8):1752-1761.

[7] 佚名.25-羟基VD₃对樱桃谷种鸭生产性能的影响[J].水禽世界,2009(3):47-48.

[8] 李新.奶牛的维生素营养[J].草食家畜,2002(3):38-40.

[9] 高道平,朱江,欧阳建华,等.矿物元素和维生素对奶牛生产性能的影响[J].上海畜牧兽医通讯,2004(3):45-46.

[10] CAO Z J,MA M,YAN X Y,et al.A simple urine-collecting apparatus and method for cows and heifers[J].Journal of Dairy Science,2009,92(10):5224-5228.

[11] 张丽英.饲料分析及饲料质量检测技术[M].4版.北京:中国农业大学出版社,2016:370.

[12] MARTINEZ N,RODNEY R M,BLOCK E,et al.Effects of prepartum dietary cation-anion difference and source of vitamin D in dairy cows:lactation performance and energy metabolism[J].Journal of Dairy Science,2017,101(3):2544-2562.

[13] WILKENS M R,OBERHEIDE I,SCHRÖDER B,et al.Influence of the combination of 25-hydroxyvitamin D₃ and a diet negative in cation-anion difference on peripartal calcium homeostasis of dairy cows[J].Journal of Dairy Science,2012,95(1):151-164.

[14] GAUCHERON F.The minerals of milk[J].Reproduction Nutrition Development,2005,45(4):473-483.

[15] RODRÍGUEZ E M R,ALAEJOS M S,ROMERO C D.Mineral concentrations in cow's milk from the Canary Island[J].Journal of Food Composition and Analysis,2001,14(4):419-430.

[16] 孙乃峰.浅谈DHI测试报告中的体细胞数(SCC)[J].中国奶牛,2008(4):63-64.

[17] MATHIEU C,VAN ETTEN E,DECALLONNE B,et al.Vitamin D and 1,25-dihydroxyvitamin D₃ as modulators in the immune system[J].The Journal of Steroid Biochemistry and Molecular Biology,2004,89/90:449-452.

[18] BINDERUP L.Immunological properties of vitamin D analogues and metabolites[J].Biochemical Pharmacology,1992,43(9):1885-1892.

[19] BOUILLON R,GARMYN M,VERSTUYF A,et al.Paracrine role for calcitriol in the immune system and skin creates new therapeutic possibilities for vitamin D analogs[J]. European Journal of Endocrinology,1995,133(1):7-16.

[20] HEWISON M.Vitamin D and the immune system[J].Journal of Endocrinology,1992,132(2):173-175.

[21] KIMURA K,REINHARDT T A,GOFF J P.Parturition and hypocalcemia blunts calcium signals in immune cells of dairy cattle[J].Journal of Dairy Science,2006,89(7):2588-2595.

[22] 张子扬.低血钙症对奶牛生产性能、饲料能源损耗、粪污排放影响的研究[D].硕士学位论文.大庆:黑龙江八一农垦大学,2016.

[23] 杨玉菊.维生素D对奶牛骨代谢调节及细胞因子的影响[D].硕士学位论文.哈尔滨:东北农业大学,2001.

[24] GOFF J P.The monitoring,prevention,and treatment of milk fever and subclinical hypocalcemia in dairy cows[J].The Veterinary Journal,2008,176(1):50-57.

[25] 李大刚.阴离子盐和维生素D对围产期奶牛钙调控机制和健康作用的研究[D].博士学位论文.北京:中国农业科学院,2006.

[26] 郑家三,夏成,王琳琳,等.过瘤胃维生素D对围产期奶牛低血钙症的影响[J].中国畜牧兽医,2013,40(8):57-60.

[27] GOFF J P,LIESEGANG A,HORST R L.Diet-induced pseudohypoparathyroidism:a hypocalcemia and milk fever risk factor[J].Journal of Dairy Science,2014,97(3):1520-1528.

[28] WEISS W P,AZEM E,STEINBERG W,et al.Effect of feeding 25-hydroxyvitamin D₃ with a negative cation-anion difference diet on calcium and vitamin D status of periparturient cows and their calves[J].Journal of Dairy Science,2015,98(8):5588-5600.

[29] MC DERMOTT C M,BEITZ D C,LITTLEDIKE E T,et al.Effects of dietary vitamin D₃ on concentrations of vitamin D and its metabolites in blood plasma and milk of dairy cows[J].Journal of Dairy Science,1985,68(8):1959-1967.

[30] 甄玉国,赵巍,王兰惠,等.围产前期不同钙水平日粮对奶牛血钙水平及钙代谢的影响[J].饲料工业,2016,37(10):37-42.

[31] 赵真,王欢,卢玉,等.老年2型糖尿病肾病患者维生素D及骨转换标志物水平的变化特征[J].临床和实验医学杂志,2015,14(23):1954-1958.

[32] 王剑,王栋,何建平,等.口服补钙对甘肃鼢鼠钙磷代谢的影响[J].动物学杂志,2010,45(4):46-51.

[33] 唐文山.骨营养不良乳牛血清钙及血清游离羟脯氨酸含量测定[J].中国兽医科技,2002,32(11):26-28.

[34] 韩进诚,姚军虎,郑永祥.25-羟基维生素D₃在动物营养中的应用[J].饲料工业,2013(10):56-59.

[35] 张艳梅.羟基-D₃的生理功能和机理研究[J].山西农业科学,2006,34(2):76-78.

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