Molecular Nutrition

Effects and Possible Mechanisms of Klotho Protein on Oxidative Stress

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  • 1. Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China;
    2. Tibet Vocational Technical College, Lasa 850000, China

Received date: 2018-02-28

  Online published: 2018-09-20

Abstract

The delection or mutation of Klotho, a newly identified anti-aging gene, can cause 3-to 4-week-old mice to show senescence. On the contrary, the overexpression of Klotho can enhance the antioxidant capacity of mice and prolong lifespan. The present study show that Klotho protein may play an antioxidant stress role by activating forkhead transcription factor O (FoxO) transcriptional activity, cyclic adenosine monophosphate (cAMP) signaling pathway and Kelch-like ECH-associated protein 1(Keap1)-nuclear factor erythroid-2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway. This review summarizes the discovery, structure, expression of Klotho and the relationship between Klotho protein and oxidative stress in order to provide ideas for alleviating oxidative stress in maintaining the health of livestock and poultry.

Cite this article

CHANG Yaqi, WEN Min, ZHAO Hua, CHEN Xiaoling, TIAN Gang, LIU Guangmang, CAI Jingyi, JIA Gang . Effects and Possible Mechanisms of Klotho Protein on Oxidative Stress[J]. Chinese Journal of Animal Nutrition, 2018 , 30(9) : 3459 -3465 . DOI: 10.3969/j.issn.1006-267x.2018.09.015

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