[1] LASERNA-MENDIETA E J,CLOONEY A G,CARRETERO-GOMEZ J F,et al.Determinants of reduced genetic capacity for butyrate synthesis by the gut microbiome in Crohn's disease and ulcerative colitis[J].Journal of Crohn's and Colitis,2018,12(2):204-216.
[2] MU C L,YANG Y X,ZHU W Y.Crosstalk between the immune receptors and gut microbiota[J].Current Protein & Peptide Science,2015,16(7):622-631.
[3] NICHOLSON J K,HOLMES E,KINROS S J,et al.Host-gut microbiota metabolic interactions[J].Science,2012,336(6086):1262-1267.
[4] LIU X F,CAO S Q,ZHANG X W.Modulation of gut microbiota-brain axis by probiotics,prebiotics,and diet[J].Journal of Agricultural and Food Chemistry,2015,63(36):7885-7895.
[5] DONOHOE D R,GARGE N,ZHANG X X,et al.The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon[J].Cell Metabolism,2011,13(5):517-526.
[6] WAHLSTRÖM A,SAYIN S I,MARSCHALL H U,et al.Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism[J].Cell Metabolism,2016,24(1):41-50.
[7] SAYIN S I,WAHLSTRÖM A,FELIN J,et al.Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid,a naturally occurring FXR antagonist[J].Cell Metabolism,2013,17(2):225-235.
[8] WAHLSTRÖM A,AL-DURY S,STÅHLMAN M,et al.Cyp3a11 is not essential for the formation of murine bile acids[J]. Biochemistry and Biophysics Reports,2017,10:70-75.
[9] CHIANG J Y L.Bile acids:regulation of synthesis[J].Journal of Lipid Research,2009,50(10):1955-1966.
[10] ZHOU H P,HYLEMON P B.Bile acids are nutrient signaling hormones[J].Steroids,2014,86:62-68.
[11] POTTHOFF M J,KLIEWER S A,MANGELSDORF D J.Endocrine fibroblast growth factors 15/19 and 21:from feast to famine[J].Genes & Development,2012,26(4):312-324.
[12] WAHLSTRÖM A,KOVATCHEVA-DATCHARY P,STÅHLMAN M,et al.Crosstalk between bile acids and gut microbiota and its impact on farnesoid X receptor signalling[J].Digestive Diseases,2017,35(3):246-250.
[13] WAHLSTRÖM A,KOVATCHEVA-DATCHARY P,STÅHLMAN M,et al.Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota[J].Journal of Lipid Research,2017,58(2):412-419.
[14] LI F,JIANG C T,KRAUSZ K W,et al.Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity[J].Nature Communications,2013,4:2384.
[15] JIA W,XIE G X,JIA W P.Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis[J].Nature Reviews Gastroenterology & Hepatology,2018,15(2):111-128.
[16] DEGIROLAMO C,RAINALDI S,BOVENGA F,et al.Microbiota modification with probiotics induces hepatic bile acid synthesis via downregulation of the Fxr-Fgf15 axis in mice[J].Cell Reports,2014,7(1):12-18.
[17] FIORUCCI S,DISTRUTTI E.Bile acid-activated receptors,intestinal microbiota,and the treatment of metabolic disorders[J].Trends in Molecular Medicine,2015,21(11):702-714.
[18] MARTIN F P,DUMAS M E,WANG Y L,et al.A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model[J].Molecular Systems Biology,2007,3(1):112.
[19] OUT C,PATANKAR J V,DOKTOROVA M,et al.Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4[J].Journal of Hepatology,2015,63(3):697-704.
[20] JANSSEN A W F,DIJK W,BOEKHORST J,et al.ANGPTL4 promotes bile acid absorption during taurocholic acid supplementation via a mechanism dependent on the gut microbiota[J].Biochimica et Biophysica Acta:Molecular and Cell Biology of Lipids,2017,1862(10):1056-1067.
[21] BARUT I,KAYA S.The diagnostic value of C-reactive protein in bacterial translocation in experimental biliary obstruction[J].Advances in Clinical and Experimental Medicine,2014,3(2):197-203.
[22] CHEN Y F,JI F,GUO J,et al.Dysbiosis of small intestinal microbiota in liver cirrhosis and its association with etiology[J].Scientific Reports,2016,6:34055.
[23] ISLAM K B M,FUKIYA S,HAGIO M,et al.Bile acid is a host factor that regulates the composition of the cecal microbiota in rats[J].Gastroenterology,2011,141(5):1773-1781.
[24] RIDLON J M,ALVES J M,HYLEMON P B,et al.Cirrhosis,bile acids and gut microbiota:unraveling a complex relationship[J].Gut Microbes,2013,4(5):382-387.
[25] INAGAKI T,MOSCHETTA A,LEE Y K,et al.Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor[J].Proceedings of the National Academy of Sciences of the United States of America,2006,103(10):3920-3925.
[26] RIDLON J M,KANG D J,HYLEMON P B,et al.Bile acids and the gut microbiome[J].Current Opinion in Gastroenterology,2014,30(3):332-338.
[27] PARSÉUS A,SOMMER N,SOMMER F,et al.Microbiota-induced obesity requires farnesoid X receptor[J].Gut,2017,66(3):429-437.
[28] ITOH M,WADA K,TAN S,et al.Antibacterial action of bile acids against
Helicobacter pylori and changes in its ultrastructural morphology:effect of unconjugated dihydroxy bile acid[J].Journal of Gastroenterology,1999,34(5):571-576.
[29] OKOLI A S,RAFTERY M J,MENDZ G L.Effects of human and porcine bile on the proteome of
Helicobacter hepaticus[J].Proteome Science,2012,10:27.
[30] LORENZO-ZÚÑIGA V,BARTOLÍ R,PLANAS R,et al.Oral bile acids reduce bacterial overgrowth,bacterial translocation,and endotoxemia in cirrhotic rats[J].Hepatology,2003,37(3):551-557.
[31] SANNASIDDAPPA T H,LUND P A,CLARKE S R.
In vitro antibacterial activity of unconjugated and conjugated bile salts on
Staphylococcus aureus[J].Frontiers in Microbiology,2017,8:1581.
[32] URDANETA V,CASADESÚS J.Interactions between bacteria and bile salts in the gastrointestinal and hepatobiliary tracts[J].Frontiers of Medicine (Lausanne),2017,4:163.
[33] PAUL S,ALEGRE K O,HOLDSWORTH S R,et al.A single-component multidrug transporter of the major facilitator superfamily is part of a network that protects
Escherichia coli from bile salt stress[J].Molecular Microbiology,2014,92(4):872-884.
[34] D'ALDEBERT E,BI MVE M J B,MERGEY M,et al.Bile salts control the antimicrobial peptide cathelicidin through nuclear receptors in the human biliary epithelium[J].Gastroenterology,2009,136(4):1435-1443.
[35] HERNÁNDEZ S B,COTA I,DUCRET A,et al.Adaptation and preadaptation of
Salmonella enterica to bile[J].PLoS Genetics,2012,8(1):e1002459.
[36] LEVERRIER P,DIMOVA D,PICHEREAU V,et al.Susceptibility and adaptive response to bile salts in
Propionibacterium freudenreichii:physiological and proteomic analysis[J].Applied and Environmental Microbiology,2003,69(7):3809-3818.
[37] RIVERA-CANCEL G,ORTH K.Biochemical basis for activation of virulence genes by bile salts in
Vibrio parahaemolyticus[J].Gut Microbes,2017,8(4):366-373.
[38] LI P,RIVERA-CANCEL G,KINCH LN,et al.Bile salt receptor complex activates a pathogenic type Ⅲ secretion system[J].eLife,2016,5:e15718.
[39] MALIK-KALE P,PARKER C T,KONKEL M E.Culture of
Campylobacter jejuni with sodium deoxycholate induces virulence gene expression[J].Journal of Bacteriology,2008,190(7):2286-2297.
[40] KREUDER A J,SCHLEINING J A,YAEGER M,et al.RNAseq reveals complex response of
campylobacter jejuni to ovine bile and
in vivo gallbladder environment[J].Frontiers in Microbiology,2017,8:940.
[41] FRANCIS M B,ALLEN C A,SHRESTHA R,et al.Bile acid recognition by the
Clostridium difficile germinant receptor,CspC,is important for establishing infection[J].PLoS Pathogens,2013,9(5):e1003356.
[42] HAMNER S,MCINNERNEY K,WILLIAMSON K,et al.Bile salts affect expression of
Escherichia coli O157:H7 genes for virulence and iron acquisition,and promote growth under iron limiting conditions[J].PLoS One,2013,8(9):e74647.
[43] BURRIN D,STOLL B,MOORE D.Digestive physiology of the pig symposium:intestinal bile acid sensing is linked to key endocrine and metabolic signaling pathways[J].Journal of Animal Science,2013,91(5):1991-2000.
[44] JOYCE S A,MACSHARRY J,CASEY P G,et al.Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut[J].Proceedings of the National Academy of Sciences of the United States of America,2014,111(20):7421-7426.
[45] 程伟伟,王少琨,王进圣,等.日粮添加胆汁酸对肉鸡生产性能、血清生化指标与屠宰性能的影响[J].中国家禽,2017,39(3):31-35.
[46] 左旭冬,王桢璐,慈晓通,等.饲粮中添加鹅脱氧胆汁酸对种鸡脂代谢、生产性能及子代肌肉发育的影响[J].动物营养学报,2016,28(8):2589-2598.
[47] JOYCE S A,SHANAHAN F,HILL C,et al.Bacterial bile salt hydrolase in host metabolism:potential for influencing gastrointestinal microbe-host crosstalk[J].Gut Microbes,2014,5(5):669-674.
[48] WEINGARDEN A R,DOSA P I,DEWINTER E,et al.Changes in colonic bile acid composition following fecal microbiota transplantation are sufficient to control
Clostridium difficile germination and growth[J].PLoS One,2016,11(1):e0147210.
[49] THERIOT C M,KOENIGSKNECHT M J,CARLSON P E,Jr,et al.Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to
Clostridium difficile infection[J].Nature Communications,2014,5:3114.
[50] DEVKOTA S,WANG Y W,MUSCH M W,et al.Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in
IL10
-/- mice[J].Nature,2012,487(7405):104-108.
[51] STALEY C,WEINGARDEN AR,KHORUTS A,et al.Interaction of gut microbiota with bile acid metabolism and its influence on disease states[J].Applied Microbiology and Biotechnology,2017,101(1):47-64.
[52] POLS T W H,NORIEGA L G,NOMURA M,et al.The bile acid membrane receptor TGR5:a valuable metabolic target[J].Digestive Diseases,2011,29(1):37-44.
[53] ZHONG M.TGR5 as a therapeutic target for treating obesity[J].Current Topics in Medicinal Chemistry,2010,10(4):386-396.
[54] IPHARRAGUERRE I R,TEDÓ G,MENOYO D,et al.Bile acids induce glucagon-like peptide 2 secretion with limited effects on intestinal adaptation in early weaned pigs[J].The Journal of Nutrition,2013,143(12):1899-1905.
[55] GENG W,LIN J.Bacterial bile salt hydrolase:an intestinal microbiome target for enhanced animal health[J].Animal Health Research Reviews,17(2):148-158.
[56] GUBAN J,KORVER D R,ALLISON G E,et al.Relationship of dietary antimicrobial drug administration with broiler performance,decreased population levels of
Lactobacillus salivarius,and reduced bile salt deconjugation in the ileum of broiler chickens[J].Poultry Science,2006,85(12):2186-2194.
