[1] BRÖER S,BRÖER A.Amino acid homeostasis and signalling in mammalian cells and organisms[J].Biochemical Journal,2017,474(12):1935-1963.
[2] CHRISTENSEN H N.Methods for distinguishing amino acid transport systems of a given cell or tissue[J].Federation Proceedings,1966,25(3):850-853.
[3] PONCET N,TAYLOR P M.The role of amino acid transporters in nutrition[J].Current Opinion in Clinical Nutrition and Metabolic Care,2013,16(1):57-65.
[4] HUNDAL H S,TAYLOR P M.Amino acid transceptors:gate keepers of nutrient exchange and regulators of nutrient signaling[J].American Journal of Physiology-Endocrinology and Metabolism,2009,296(4):E603-E613.
[5] POCHINI L,SCALISE M,GALLUCCIO M,et al.Membrane transporters for the special amino acid glutamine:structure/function relationships and relevance to human health[J].Frontiers in Chemistry,2014,2:61.
[6] TAYLOR P M.Role of amino acid transporters in amino acid sensing[J].The American Journal of Clinical Nutrition,2013,99(1):223S-230S.
[7] PINGITORE P,POCHINI L,SCALISE M,et al.Large scale production of the active human ASCT2(SLC1A5) transporter in
Pichia pastoris-functional and kinetic asymmetry revealed in proteoliposomes[J].Biochimica et Biophysica Acta (BBA)-Biomembranes,2013,1828(9):2238-2246.
[8] DEL AMO E M,URTTI A,YLIPERTTULA M.Pharmacokinetic role of
L-type amino acid transporters LAT1 and LAT2[J].European Journal of Pharmaceutical Sciences,2008,35(3):161-174.
[9] CHAUDHRY F A,SCHMITZ D,REIMER R J,et al.Glutamine uptake by neurons:interaction of protons with system a transporters[J].The Journal of Neuroscience,2002,22(1):62-72.
[10] BIONAZ M,LOOR J J.Gene networks driving bovine mammary protein synthesis during the lactation cycle[J].Bioinformatics and Biology Insights,2011,5:83-98.
[11] KIM S G,BUEL G R,BLENIS J.Nutrient regulation of the mTOR complex 1 signaling pathway[J].Molecules and Cells,2013,35(6):463-473.
[12] GALLINETTI J,HARPUTLUGIL E,MITCHELL J R.Amino acid sensing in dietary-restriction-mediated longevity:roles of signal-transducing kinases GCN2 and TOR[J].Biochemical Journal,2013,449(1):1-10.
[13] KIM D H,SARBASSOV D D,ALI S M,et al.mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery[J].Cell,2002,110(2):163-175.
[14] SAXTON R A,SABATINI D M.mTOR signaling in growth,metabolism,and disease[J].Cell,2017,168(6):960-976.
[15] ZHANG M C,ZHAO S G,WANG S S,et al.d-Glucose and amino acid deficiency inhibits casein synthesis through JAK2/STAT5 and AMPK/mTOR signaling pathways in mammary epithelial cells of dairy cows[J].Journal of Dairy Science,2018,101(2):1737-1746.
[16] EFEYAN A,ZONCU R,SABATINI D M.Amino acids and mTORC1:from lysosomes to disease[J].Trends in Molecular Medicine,2012,18(9):524-533.
[17] HARA K,YONEZAWA K,WENG Q P,et al.Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism[J].Journal of Biological Chemistry,1998,273(23):14484-14494.
[18] DURÁN R V,HALL M N.Regulation of TOR by small GTPases[J].EMBO Reports,2012,13(2):121-128.
[19] KIMBALL S R,JEFFERSON L S.Molecular mechanisms through which amino acids mediate signaling through the mammalian target of rapamycin[J].Current Opinion in Clinical Nutrition and Metabolic Care,2004,7(1):39-44.
[20] HAN J M,JEONG S J,PARK M C,et al.Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway[J].Cell,2012,149(2):410-424.
[21] ZONCU R,BAR-PELED L,EFEYAN A,et al.mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H
+-ATPase[J].Science,2011,334(6056):678-683.
[22] KIM J,OKAMOTO H,HUANG Z J,et al.Amino acid transporter Slc38a5 controls glucagon receptor inhibition-induced pancreatic α cell hyperplasia in mice[J].Cell Metabolism,2017,25(6):1348-1361.
[23] PINILLA J,ALEDO J C,CWIKLINSKI E,et al.SNAT2 transceptor signalling via mTOR:a role in cell growth and proliferation[J].Frontiers in Bioscience,2011,3:1289-1299.
[24] NICKLIN P,BERGMAN P,ZHANG B L,et al.Bidirectional transport of amino acids regulates mTOR and autophagy[J].Cell,2009,136(3):521-534.
[25] PALⅡ S S,THIAVILLE M M,PAN Y X,et al.Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2(SNAT2) system A transporter gene[J].Biochemical Journal,2006,395(3):517-527.
[26] USUI T,NAGUMO Y,WATANABE A,et al.Brasilicardin A,a natural immunosuppressant,targets amino acid transport system L[J].Chemistry & Biology,2006,13(11):1153-1160.
[27] DICKINSON J M,DRUMMOND M J,COBEN J R,et al.Aging differentially affects human skeletal muscle amino acid transporter expression when essential amino acids are ingested after exercise[J].Clinical Nutrition,2013,32(2):273-280.
[28] EVANS K,NASIM Z,BROWN J,et al.Acidosis-sensing glutamine pump SNAT2 determines amino acid levels and mammalian target of rapamycin signalling to protein synthesis in L6 muscle cells[J].Journal of the American Society of Nephrology,2007,18(5):1426-1436.
[29] GLYNN E L,FRY C S,DRUMMOND M J,et al.Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women[J].The Journal of Nutrition,2010,140(11):1970-1976.
[30] DICKINSON J M,FRY C S,DRUMMOND M J,et al.Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids[J].The Journal of Nutrition,2011,141(5):856-862.
[31] GOBERDHAN D C I,MEREDITH D,BOYD C A R,et al.PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids[J].Development,2005,132(10):2365-2375.
[32] PONCET N,MITCHELL F E,IBRAHIM A F M,et al.The catalytic subunit of the system L1 amino acid transporter (Slc7a5) facilitates nutrient signaling in mouse skeletal muscle[J].PLoS One,2014,9(2):e89547.
[33] BAUMRUCKER C R.Amino acid transport systems in bovine mammary tissue[J].Journal of Dairy Science,1985,68(9):2436-2451.
[34] BEQUETTE B J,HANIGAN M D,CALDER A G,et al.Amino acid exchange by the mammary gland of lactating goats when histidine limits milk production[J].Journal of Dairy Science,2000,83(4):765-775.
[35] BAIRD F E,BETT K J,MACLEAN C,et al.Tertiary active transport of amino acids reconstituted by coexpression of system A and L transporters in
Xenopus oocytes[J].American Journal of Physiology:Endocrinology and Metabolism,2009,297(3):E822-E829.
[36] MOSHEL Y,RHOADS R E,BARASH I.Role of amino acids in translational mechanisms governing milk protein synthesis in murine and ruminant mammary epithelial cells[J].Journal of Cellular Biochemistry,2006,98(3):685-700.
[37] SANCAK Y,PETERSON T R,SHAUL Y D,et al.The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1[J].Science,2008,320(5882):1496-1501.
[38] APPUHAMY J A D R N,KNOEBEL N A,NAYANANJALIE W A D,et al.Isoleucine and leucine independently regulate mTOR signaling and protein synthesis in MAC-T cells and bovine mammary tissue slices[J].The Journal of Nutrition,2012,142(3):484-491.
[39] APELO S I A,SINGER L M,LIN X Y,et al.Isoleucine,leucine,methionine,and threonine effects on mammalian target of rapamycin signaling in mammary tissue[J].Journal of Dairy Science,2014,97(2):1047-1056.
[40] HUNDAL H S,TAYLOR P M.Amino acid transceptors:gate keepers of nutrient exchange and regulators of nutrient signaling[J].American Journal of Physiology:Endocrinology and Metabolism,2009,296(4):E603-E613.
[41] DRUMMOND M J,GLYNN E L,FRY C S,et al.An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle[J].American Journal of Physiology:Endocrinology and Metabolism,2010,298(5):E1011-E1018.
[42] LI S S,LOOR J J,LIU H Y,et al.Optimal ratios of essential amino acids stimulate β-casein synthesis via activation of the mammalian target of rapamycin signaling pathway in MAC-T cells and bovine mammary tissue explants[J].Journal of Dairy Science,2017,100(8):6676-6688.
[43] GAO H N,ZHAO S G,ZHENG N,et al.Combination of histidine, lysine, methionine, and leucine promotes β-casein synthesis via the mechanistic target of rapamycin signaling pathway in bovine mammary epithelial cells[J].Journal of Dairy Science,2017,100(9):7696-7709.
[44] BRÖER A,JUELICH T,VANSLAMBROUCK J M,et al.Impaired nutrient signaling and body weight control in a Na
+ neutral amino acid cotransporter (Slc6a19)-deficient mouse[J].Journal of Biological Chemistry,2011,286(30):26638-26651.
[45] VAN WINKLE L J,TESCH J K,SHAH A,et al.System B
0,+ amino acid transport regulates the penetration stage of blastocyst implantation with possible long-term developmental consequences through adulthood[J].Human Reproduction Update,2005,12(2):145-157.
[46] ROOS S,KANAI Y,PRASAD P D,et al.Regulation of placental amino acid transporter activity by mammalian target of rapamycin[J].American Journal of Physiology:Cell Physiology,2009,296(1):C142-C150.
