Molecular Nutrition

Effect of Dietary Fiber on Intestinal Barrier Function in Pigs

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  • Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory of Animal Disease-Resistance Nutrition of Education Ministry, Chengdu 611130, China

Received date: 2018-04-05

  Online published: 2018-10-20

Abstract

The intestinal barrier mainly includes normal gut bacteria, mucus layer, intestinal epithelial cells and immune barrier, whose function is closely related to dietary. Dietary fiber refers to carbohydrates that cannot be digested and absorbed by their endogenous digestive enzymes in the intestinal tract of mammals, commonly known as non-starch polysaccharides (NSP), which mainly includes cellulose, hemicellulose, lignin and β-glucan, etc. Dietary fiber can enhance intestinal mucosal barrier, improve the structure of microbial community and improve the ratio of probiotics to pathogenic bacteria, etc. The present review summarizes the effect and mechanism of dietary fiber on intestinal barrier function of pigs for promoting the rational and effective utilization of dietary fiber in swine industry.

Cite this article

FENG Jiangxin, CHEN Daiwen, YU Bing, HE Jun, ZHENG Ping . Effect of Dietary Fiber on Intestinal Barrier Function in Pigs[J]. Chinese Journal of Animal Nutrition, 2018 , 30(10) : 3828 -3835 . DOI: 10.3969/j.issn.1006-267x.2018.10.005

References

[1] HIPSLEY E H.Dietary "fiber" and pregnancy toxaemia[J].British Medical Journal,1953,2(4833):420-422.  

[2] DIKEMAN C L,FAHEY G C,Jr.Viscosity as related to dietary fiber:a review[J].Critical Reviews in Food Science and Nutrition,2006,46(8):649-663.  

[3] BALANDRAN-QUINTANA R R,BARBOSA-CANOVAS G V,ZAZUETA-MORALES J J,et al.Functional and nutritional properties of extruded whole pinto bean meal (Phaseolus Vulgaris L.)[J].Journal of Food Science,2010,63(1):113-116.

[4] 王向峰.水溶性和不溶性纤维在幼龄单胃动物日粮中的功能研究[D].硕士学位论文.福州:福建农林大学,2008.

[5] MAYNARD C L,ELSON C O,HATTON R D,et al.Reciprocal interactions of the intestinal microbiota and immune system[J].Nature,2012,489(7415):231-241.  

[6] SENDER R,FUCHS S,MILO R.Revised estimates for the number of human and bacteria cells in the body[J].PLoS Biology,2016,14(8):e1002533.

[7] LESER T D,AMENUVOR J Z,JENSEN T K,et al.Culture-independent analysis of gut bacteria:the pig gastrointestinal tract microbiota revisited[J].Applied and Environmental Microbiology,2002,68(2):673-690.  

[8] MOLIST F,DE SEGURA A G,PÉREZ J F,et al.Effect of wheat bran on the health and performance of weaned pigs challenged with Escherichia coli K88+[J].Livestock Science 2010,133(1/2/3):214-217.

[9] OWUSU-ASIEDU A,PATIENCE J F,LAARVELD B,et al.Effects of guar gum and cellulose on digesta passage rate,ileal microbial populations,energy and protein digestibility,and performance of grower pigs[J].Journal of Animal Science,2006,84(4):843-852.  

[10] CHE L Q,CHEN H,YU B,et al.Long-term intake of pea fiber affects colonic barrier function,bacterial and transcriptional profile in pig model[J].Nutrition and Cancer,2014,66(3):388-399.  

[11] CHEN H,MAO X B,CHE L Q,et al.Impact of fiber types on gut microbiota,gut environment and gut function in fattening pigs[J].Animal Feed Science and Technology,2014,195(9):101-111.

[12] 王嘉为,张蕾,祝皎月,等.饲粮中添加苜蓿草粉对生长猪结肠微生物区系及其代谢产物的影响[J].动物营养学报,2016,28(9):2715-2723.

[13] HAENEN D,DA SILVA C S,ZHANG J,et al.Resistant starch induces catabolic but suppresses immune and cell division pathways and changes the microbiome in the proximal colon of male pigs[J].The Journal of Nutrition,2013,143(12):1889-1898.  

[14] VAREL V H,YEN J T.Microbial perspective on fiber utilization by swine[J].Journal of Animal Science,1997,75(10):2715-2722.  

[15] SATCHITHANANDAM S,KLURFELD D M,CALVERT R J,et al.Effects of dietary fibers on gastrointestinal mucin in rats[J].Nutrition Research,1996,16(7):1163-1177.  

[16] ZHOU L P,FANG L D,SUN Y,et al.Effects of a diet high in resistant starch on fermentation end-products of protein and mucin secretion in the colons of pigs[J].Starch,2017,69(7/8):1600032.

[17] VILA F M.Effects of dietary fiber on swine intestinal epithelial and immune response[D].Master's Thesis.Minnesota:University of Minnesota,2017.

[18] CHEN H,MAO X B,HE J,et al.Dietary fiber affects intestinal mucosal barrier function and regulates intestinal bacteria in weaning piglets[J].British Journal of Nutrition,2013,110(1):1837-1848.

[19] PODOLSKY D K.Mucosal immunity and inflammation.Innate mechanisms of mucosal defense and repair:the best offense is a good defense[J].American Journal of Physiology,1999,277(1):G495-G499.

[20] FURUSE M.Molecular basis of the core structure of tight junctions[J].Cold Spring Harbor Perspectives in Biology,2010,2(1):a002907.

[21] 张叶秋,郝帅帅,高硕,等.米糠高纤维日粮对苏淮猪生长性能及肠道功能的影响[J].南京农业大学学报,2016,36(5):807-813.

[22] 吴维达,解竞静,张宏福.不同日粮纤维对生长猪养分消化率和肠道结构形态的影响[J].畜牧与兽医,2016,48(6):57-60.

[23] MACPHERSON A J,MCCOY K D,JOHANSEN F E,et al.The immune geography of IgA induction and function[J].Mucosal Immunology,2008,1:11-22.

[24] VINOLO M A R,RODRIGUES H G,HATANAKA E,et al.Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils[J].The Journal of Nutritional Biochemistry,2011,22(9):849-855.  

[25] MONTAGNE L,PLUSKE J R,HAMPSON D J.A review of interactions between dietary fibre and the intestinal mucosa,and their consequences on digestive health in young non-ruminant animals[J].Animal Feed Science and Technology,2003,108(1/2/3/4):95-117.

[26] BOUHNIK Y,RASKINE L,SIMONEAU G,et al.The capacity of nondigestible carbohydrates to stimulate fecal bifidobacteria in healthy humans:a double-blind,randomized,placebo-controlled,parallel-group,dose-response relation study[J].The American Journal of Clinical Nutrition,2004,80(6):1658-1664.  

[27] KNUDSEN K E B,HEDEMANN M S,LÆRKE H N.The role of carbohydrates in intestinal health of pigs[J].Animal Feed Science and Technology,2001,83(2):41-53.

[28] FREIRE J P B,GUERREIRO A J G,CUNHA L F,et al.Effect of dietary fibre source on total tract digestibility,caecum volatile fatty acids and digestive transit time in the weaned piglet[J].Animal Feed Science and Technology,2000,87(1/2):71-83.

[29] HAMAKER B R,TUNCIL Y E.A perspective on the complexity of dietary fiber structures and their potential effect on the gut microbiota[J].Journal of Molecular Biology,2014,426(23):3838-3850.  

[30] DESAI M S,SEEKATZ A M,KOROPATKIN N M,et al.A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility[J].Cell,2016,167(5):1339-1353.e21.  

[31] TOPPING D L,CLIFTON P M.Short-chain fatty acids and human colonic function:roles of resistant starch and nonstarch polysaccharides[J].Physiological Reviews,2001,81(3):1031-1064.  

[32] 罗玉衡,陈洪,余冰,等.短期或长期饲喂高水平豌豆纤维对猪盲肠微生物群落结构和代谢产物的影响[J].畜牧兽医学报,2017,48(8):1459-1467.

[33] CARNEIRO M S C,LORDELO M M,CUNHA L F,et al.Effects of dietary fibre source and enzyme supplementation on faecal apparent digestibility,short chain fatty acid production and activity of bacterial enzymes in the gut of piglets[J].Animal Feed Science and Technology,2008,146(1/2):124-136.

[34] COX M A,JACKSON J,STANTON M,et al.Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E(2) and cytokines[J].World Journal of Gastroenterology,2009,15(44):5549-5557.  

[35] PUERTOLLANO E,KOLIDA S, YAQOOB P.Biological significance of short-chain fatty acid metabolism by the intestinal microbiome[J].Current Opinion in Clinical Nutrition and Metabolic Care,2014,17(2):139-144.  

[36] TAN J,MCKENZIE C,POTAMITIS M,et al.The role of short-chain fatty acids in health and disease[J].Advances in Immunology,2014,121:91-119.

[37] BAILEY M,PLUFIKEU F J,ROTHKÖTTER H J,et a1.Regulation of mucosal immune responses in effector sites[J].Proceedings of the Nutrition Society,2001,60(4):427-435.  

[38] CLEOPHAS M C,CRI?AN T O,LEMMERS H,et al.Suppression of monosodium urate crystal-induced cytokine production by butyrate is mediated by the inhibition of class Ⅰ histone deacetylases[J].Annals of the Rheumatic Diseases,2016,75(3):593-600.  
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