Molecular Nutrition

Plant Polysaccharides: Mechanism of Anti-Oxidant Action through Nuclear Factor κB and Mitogen-Activated Protein Kinase/Nuclear Factor Erythroid 2-Related Factor 2 Signaling Pathways

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  • Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China

Received date: 2018-03-29

  Online published: 2018-10-20

Abstract

Plant polysaccharides, one of the main bioactive components in plant extracts, have diverse bioactivities, such as resisting oxidative stress, boosting immunity and anti-tumor. For the antioxidative action, plant polysaccharides reduce the inflammatory factor secretion and attenuate the damage caused by oxidative stress through nuclear factor κB (NF-κB) signaling pathway; plant polysaccharides scavenge free radicals, improve activities and contents of antioxidant enzymes, and enhance cellular or body resistance to oxidative stress through mitogen-activated protein kinase (MAPK)/nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. This paper reviewed the production and the damage of oxidative stress, as well as the present situation and drawbacks of plant polysaccharides as an antioxidant regent in livestock production for the purpose of providing a theoretical foundation for the further study and application of plant polysaccharides as an antioxidant regent.

Cite this article

WANG Lixue, XIE Yuhuai, YANG Weiren, YANG Zaibin, ZHANG Guiguo . Plant Polysaccharides: Mechanism of Anti-Oxidant Action through Nuclear Factor κB and Mitogen-Activated Protein Kinase/Nuclear Factor Erythroid 2-Related Factor 2 Signaling Pathways[J]. Chinese Journal of Animal Nutrition, 2018 , 30(10) : 3857 -3863 . DOI: 10.3969/j.issn.1006-267x.2018.10.009

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