[1] SCHAART M W,SCHIERBEEK H,VAN DER SCHOOR R D,et al.Threonine utilization is high in the intestine of piglets[J].The Journal of Nutrition,2005,135(4):765-770.

[2] LI P,YIN Y L,LI D F,et al.Amino acids and immune function[J].British Journal of Nutrition,2007,98(2):237-252.

[3] MAO X,ZENG X,QIAO S,et al.Specific roles of threonine in intestinal mucosal integrity and barrier function[J].Frontiers in Bioscience,2011,3:1192-1200.
[4] FAURE M,MOËNNOZ D,MONTIGON F,et al.Dietary threonine restriction specifically reduces intestinal mucin synthesis in rats[J].The Journal of Nutrition,2005,135(3):486-491.

[5] MUNASINGHE L L,ROBINSON J L,HARDING S V,et al.Protein synthesis in mucin-producing tissues is conserved when dietary threonine is limiting in piglets[J].The Journal of Nutrition,2017,147(2):202-210.

[6] AZZAM M M M,ZOU X T,DONG X Y,et al.Effect of supplemental
L-threonine on mucin 2 gene expression and intestine mucosal immune and digestive enzymes activities of laying hens in environments with high temperature and humidity[J].Poultry Science,2011,90(10):2251-2256.

[7] TREVISI P,CORRENT E,MAZZONI M,et al.Effect of added dietary threonine on growth performance,health,immunity and gastrointestinal function of weaning pigs with differing genetic susceptibility to
Escherichia coli infection and challenged with
E.coli K88ac[J].Journal of Animal Physiology and Animal Nutrition,2015,99(3):511-520.

[8] GÖKE M N,SCHNEIDER M,BEIL W,et al.Differential glucocorticoid effects on repair mechanisms and NF-κB activity in the intestinal epithelium[J].Regulatory Peptides,2002,105(3):203-214.

[9] 韩国全,余冰,陈代文,等.苏氨酸对体外培养感染伪狂犬病毒猪空肠上皮细胞免疫相关基因表达的影响[J].动物营养学报,2012,24(3):487-496.
[10] WANG X,QIAO S Y,YIN Y L,et al.A deficiency or excess of dietary threonine reduces protein synthesis in jejunum and skeletal muscle of young pigs[J].The Journal of Nutrition,2007,137(6):1442-1446.

[11] REN M,LIU X T,WANG X,et al.Increased levels of standardized ileal digestible threonine attenuate intestinal damage and immune responses in
Escherichia coli K88
+ challenged weaned piglets[J].Animal Feed Science and Technology,2014,195:67-75.
[12] CUMMINS A G,THOMPSON F M.Effect of breast milk and weaning on epithelial growth of the small intestine in human[J].Gut,2002,51(5):748-754.

[13] 李艳云,张艳英,史秋梅,等.紫锥菊多糖对LPS损伤后IEC-6细胞的增殖作用[J].安徽农业科学,2015,43(14):19-21,73.
[14] CHIBA H,OSANAI M,MURATA M,et al.Transmembrane proteins of tight junctions[J].Biochimcaet Biophysica Acta:Biomembranes,2008,1778(3):588-600.

[15] MITIC L,VAN TIALLIE C M,ANDERSON J M.Molecular physiology and pathophysiology of tight junctions Ⅰ.Tight junction structure and function:lessons from mutant animals and proteins[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2000,279(2):G250-G254.
[16] FURUSE M,HATE M,FURUSE K,et al.Claudin-based tight junctions are crucial for the mammalian epidermal barrier:a lesson from claudin-1-deficient mice[J].The Journal of Cell Biology,2002,156(6):1099-1111.

[17] ZHANG S H,REN M,ZENG X F,et al.Leucine stimulates ASCT2 amino acid transporter expression in porcine jejunal epithelial cell line (IPEC-J2) through PI3K/Akt/mTOR and ERK signaling pathways[J].Amino Acids,2014,46(12):2633-2642.

[18] REN M,ZHANG S H,LIU X T,et al.Different lipopolysaccharide branched-chain amino acids modulate porcine intestinal endogenous β-defensin expression through the Sirt1/ERK/90RSK pathway[J].Journal of Agricultural and Food Chemistry,2016,64(17):3371-3379.

[19] XIAO H,ZENG L M,SHAO F Y,et al.The role of nitric oxide pathway in arginine transport and growth of IPEC-1 cells[J].Oncotarget,2017,8(18):29976-29983.