Molecular Nutrition

Distribution and Chemosensing Role of Enteroendocrine Cells in Piglets

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  • 1. Agro-Biological Gene Research Center, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China;
    2. Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China

Received date: 2018-04-25

  Online published: 2018-11-20

Abstract

Enteroendocrine cells (EECs) are the specialized epithelial cells of gastrointestinal mucosa, whose number exceeds total amount of other endocrine cells in the body, collectively forming the body's largest endocrine organ. Previous studies have shown that there are at least 20 EECs found in the gastrointestinal tract of mammals, and they can secrete many gut hormones which play an important role in regulating gastrointestinal physiology, energy balance, feed intake, gut chemosensing, metabolism of nutrients, and immune regulation. Thus, this review summarizes the classification of EECs, the research techniques of EECs, as well as the research progress on EECs in the gastrointestinal tract of piglets. The chemosensing role of the EECs, the relationship between the EECs and immunity, and impact of the gut microbiota on the gut chemosensing will also be discussed, aiming to provide insights for potential nutritional regulation on improving intestinal health, and growth and development of piglets.

Cite this article

ZHU Cui, YANG Jun, JIANG Zongyong, CHEN Zhuang . Distribution and Chemosensing Role of Enteroendocrine Cells in Piglets[J]. Chinese Journal of Animal Nutrition, 2018 , 30(11) : 4286 -4294 . DOI: 10.3969/j.issn.1006-267x.2018.11.002

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