Molecular Nutrition

Research Progress in Regulation of Toll-Like Receptor-Nuclear Factor-κB Signaling Pathway by Probiotics

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  • College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China

Received date: 2018-04-17

  Online published: 2018-11-20

Abstract

Toll-like receptor (TLR) is the main pattern recognition receptor for host cells to identify various pathogenic microorganisms. Nuclear factor-κB (NF-κB) is the hub of downstream signaling pathway of TLR, and TLR-NF-κB signaling pathway exists in almost all cells. When cells are stimulated, the TLR-NF-κB signaling pathway is stimulated which leads to inflammation, immunity and many pathological reactions. Probiotics can enhance immunity, enrich intestine beneficial bacteria and inhibit the production of inflammatory factors in the intestinal diseases. Some specific probiotics can regulate the TLR-NF-κB signaling pathway to regulate the expression of inflammatory factors and improve the intestinal mucosa inflammation. In this paper, the main structural functions of TLR and NF-κB, TLR-NF-κB signaling pathway, and the regulation mechanisms of probiotics on TLR-NF-κB signaling pathway were reviewed which provided a new idea for further study on the role of probiotics in the host organism.

Cite this article

NIE Lian, ZHANG Aizhong, JIANG Ning, YANG Zhuonina . Research Progress in Regulation of Toll-Like Receptor-Nuclear Factor-κB Signaling Pathway by Probiotics[J]. Chinese Journal of Animal Nutrition, 2018 , 30(11) : 4342 -4348 . DOI: 10.3969/j.issn.1006-267x.2018.11.009

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