Effects of Short-Term Feed Restriction on Lipid Metabolism in Adipose Tissue of Growing Meat Rabbits

ZHANG Bin, LIU Lei, WANG Cheng, LIU Hanzhong, YU Zhiju, LI Fuchang

doi:10.3969/j.issn.1006-267x.2018.11.031

Chinese Journal of Animal Nutrition >

2018 , Vol. 30 >Issue 11: 4551 - 4558

DOI: https://doi.org/10.3969/j.issn.1006-267x.2018.11.031

Molecular Nutrition

Effects of Short-Term Feed Restriction on Lipid Metabolism in Adipose Tissue of Growing Meat Rabbits

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1. Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China;
2. Shandong Jianyuan Science and Technology Co., Ltd., Tai'an 271000, China;
3. Sichuan Academy of Grassland Sciences, Chengdu 610091, China

Received date: 2018-05-02

Online published: 2018-11-20

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Abstract

The aim of this experiment was to investigate the effects of short-term feed restriction on lipid metabolism related genes expression and related signaling pathways in adipose tissue of growing meat rabbits, and to illustrate the regulation mechanism of energy homeostasis of growing meat rabbits. A total of 40 IRA rabbits with a similar weight at 40 days of age were randomly divided into 2 groups:the control group (free feeding group) and the feed restriction group (the feeding amount was about 70% of the control group), each group had 20 repetitions with 1 rabbit each. The test lasted for 5 days. The results showed as follows:1) compared with the control group, short-term feed restriction significantly reduced the daily weight gain of growing meat rabbits (P<0.05), reduced the total fat deposition in growing meat rabbits, and had no significant effect on the shoulder fat and perirenal fat deposition in growing meat rabbits (P>0.05). 2) Compared with the control group, short-term feed restriction significantly reduced the gene expressions of fatty acid synthetase(FAS), acetyl coenzyme A carboxylase(ACC) and lipoprotein lipase(LPL) (P<0.05), but significantly increased the gene expressions of peroxisome proliferators activate receptors(PPARα, PPARγ), carnitine acyl transferase(CPT1,CPT2) and G-protein-coupled receptors(GPR41) (P<0.05), but had no significant influence on the gene expressions of hormone-sensitive lipase(HSL) and G-protein-coupled receptors(GPR43) in adipose tissue (P>0.05). 3) Compared with the control group, short-term feed restriction had no significant effect on the triglyceride(TG) concentration in adipose tissue and phosphorylation of adenosine 5'-monophosphate (AMP)-activated protein kinase(AMPK) protein expression (P>0.05). In conclusion, short-term feed restriction can inhibit the synthesis of fatty acids and promote the decomposition of fatty acids in adipose tissue of growing meat rabbits. The PPARα and GPR41 signal channels may be involved in the regulation of energy homeostasis in adipose tissue of growing meat rabbits.

Key words： growing meat rabbit; short-term feed restriction; lipid metabolism; gene expression; signal channel

Cite this article

ZHANG Bin, LIU Lei, WANG Cheng, LIU Hanzhong, YU Zhiju, LI Fuchang . Effects of Short-Term Feed Restriction on Lipid Metabolism in Adipose Tissue of Growing Meat Rabbits[J]. Chinese Journal of Animal Nutrition, 2018 , 30(11) : 4551 -4558 . DOI: 10.3969/j.issn.1006-267x.2018.11.031

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