Molecular Nutrition

Physiological Action and Mechanism of Guanidine Acetic Acid and Its Application in Broiler chickens and Pigs Production

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  • College of Animal Science, Hunan Agricultural University, Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China

Received date: 2018-05-16

  Online published: 2018-12-19

Abstract

Guanidine acetic acid, a new nutritive feed additive, has certain effects on improving the production performance of broiler chickens and pigs, promoting energy metabolism, accelerating protein deposition, improving antioxidant capacity, and improving meat quality. This article reviews the metabolic pathways, physiological effects and mechanisms of guanidine acetic acid, as well as the latest advances in the production performance and meat quality of broiler chickens and pigs, with a view to providing references for the further research and exploration of guanidine acetic acid.

Cite this article

BAN Bo, JIANG Qingyou, YANG Tai, TIAN Kexiong . Physiological Action and Mechanism of Guanidine Acetic Acid and Its Application in Broiler chickens and Pigs Production[J]. Chinese Journal of Animal Nutrition, 2018 , 30(12) : 4799 -4805 . DOI: 10.3969/j.issn.1006-267x.2018.12.005

References

[1] 王连生,张圆圆,单安山.胍基乙酸的体内代谢及在动物生产中的应用[J].中国畜牧兽医,2010,37(6):13-16.



[2] OSTOJIC S M.Guanidinoacetic acid as a performance-enhancing agent[J].Amino Acids,2015,48(8):1867-1875.



[3] BLOCH K,SCHOENHEIMER R.The biological origin of the amidine group in creatine[J].Journal of Biological Chemistry,1940,134:785-786



[4] STEAD L M,AU K P,JACOBS R L,et al.Methylation demand and homocysteine metabolism:effects of dietary provision of creatine and guanidinoacetate[J].American Journal of Physiology-Endocrinology and Metabolism,2001,281(5):E1095-E1100.



[5] 张俊玲,张德福,石凤云,等.胍基乙酸在动物生产上的研究进展[J].中国畜牧杂志,2016,52(4):63-66.



[6] MACCORMICK V M,HILL L M,MACNEIL L,et al.Elevation of creatine in red blood cells in vegetarians and nonvegetarians after creatine supplementation[J].Canadian Journal of Applied Physiology,2004,29(6):704-713.  



[7] DILGER R N,BRYANT-ANGELONI K,PAYNE R L,et al.Dietary guanidino acetic acid is an efficacious replacement for arginine for young chicks[J].Poultry Science,2013,92(1):171-177.  



[8] KHARBANDA K K,TODERO S L,MOATS J C,et al.Alcohol consumption decreases rat hepatic creatine biosynthesis via altered guanidinoacetate methyltransferase activity[J].Alcoholism Clinical & Experimental Research,2014,38(3):641-648.  



[9] SETOUE M,OHUCHI S,MORITA T,et al.Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats[J].Bioscience,Biotechnology,and Biochemistry,2008,72(7):1696-1703.  



[10] OHUCHI S,MATSUMOTO Y,MORITA T,et al.High-casein diet suppresses guanidinoacetic acid-induced hyperhomocysteinemia and potentiates the hypohomocysteinemic effect of serine in rats[J].Bioscience,Biotechnology,and Biochemistry,2008,72(12):3258-3264.  



[11] LIU Y Q,JIA Z,HAN F,et al.Suppression effects of betaine-enriched spinach on hyperhomocysteinemia induced by guanidinoacetic acid and choline deficiency in rats[J].The Scientific World Journal,2014,2014:904501.



[12] 王娇,李庆霞,杨信,等.胍基乙酸在家禽生产中的应用[J].中国饲料,2017(20):11-13.



[13] ZHAO C R,SHANG L H,WANG W Y,et al.Myocellular creatine and creatine transporter serine phosphorylation after starvation[J].Journal of Surgical Research,2002,105(1):10-16.  



[14] DA SILVA R P,NISSIM I,BROSNAN M E,et al.Creatine synthesis:hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo[J].American Journal of Physiology-Endocrinology and Metabolism,2009,296(2):E256-E261.



[15] DA SILVA R,CLOW K,BROSNAN J T,et al.Synthesis of guanidinoacetate and creatine from amino acids by rat pancreas[J].British Journal of Nutrition,2014,111(4):571-577.  



[16] KOMOTO J,TAKATA Y,YAMADA T,et al.Monoclinic guanidinoacetate methyltransferase and gadolinium ion-binding characteristics[J].Acta Crystallographica,2003,59(Pt 9):1589-1596.



[17] KOMOTO J,YAMADA T,TAKATA Y,et al.Catalytic mechanism of guanidinoacetate methyltransferase:crystal structures of guanidinoacetate methyltransferase ternary complexes[J].Biochemistry,2004,43(45):14385-14394.  



[18] SCHMIDT A,MARESCAU B,BOEHM E A,et al.Severely altered guanidino compound levels,disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency[J].Human Molecular Genetics,2004,13(9):905-921.  



[19] CHOE C U,NABUURS C,STOCKEBRAND M C,et al.L-arginine:glycine amidinotransferase deficiency protects from metabolic syndrome[J].Human Molecular Genetics,2013,22(1):110-123.  



[20] TACHIKAWA M,FUJINAWA J,TAKAHASHI M,et al.Expression and possible role of creatine transporter in the brain and at the blood-cerebrospinal fluid barrier as a transporting protein of guanidinoacetate,an endogenous convulsant[J].Journal of Neurochemistry,2008,107(3):768-778.  



[21] TACHIKAWA M,KASAI Y,YOKOYAMA R,et al.The blood-brain barrier transport and cerebral distribution of guanidinoacetate in rats:involvement of creatine and taurine transporters[J].Journal of Neurochemistry,2009,111(2):499-509.  



[22] OSTOJIC S M.A new perspective to improve brain bioenergetics in disorders with functional GAMT and CT1[J].Biomedicine & Pharmacotherapy,2016,84:1833.



[23] TACHIKAWA M,IKEDA S,FUJINAWA J,et al.γ-aminobutyric acid transporter 2 mediates the hepatic uptake of guanidinoacetate,the creatine biosynthetic precursor,in rats[J].PLoS One,2012,7(2):e32557.



[24] SHARIDEH H,ESMAEILE N L,ZAGHARI M,et al.Effect of feeding guanidinoacetic acid and L-arginine on the fertility rate and sperm penetration in the perivitelline layer of aged broiler breeder hens[J].Journal of Animal Physiology and Animal Nutrition,2016,100(2):316-322.  



[25] TAPEH R S,ZHANDI M,ZAGHARI M,et al.Effects of guanidinoacetic acid diet supplementation on semen quality and fertility of broiler breeder roosters[J].Theriogenology,2017,89:178-182.



[26] MURAKAMI A E,RODRIGUEIRO R J B,SANTOS T C,et al.Effects of dietary supplementation of meat-type quail breeders with guanidinoacetic acid on their reproductive parameters and progeny performance[J].Poultry Science,2014,93(9):2237-2244.  



[27] RINGEL J,LEMME A,KNOX A,et al.Effects of graded levels of creatine and guanidino acetic acid in vegetable-based diets on performance and biochemical parameters in muscle tissue[C]//Proceedings of the 16th European symposium on poultry nutrition,[S.l.]:[s.n.],2007:387-390.



[28] MCBREAIRTY L E,ROBINSON J L,FURLONG K R,et al.Guanidinoacetate is more effective than creatine at enhancing tissue creatine stores while consequently limiting methionine availability in Yucatan miniature pigs[J].PLoS One,2015,10(6):e0131563.



[29] RINGEL J,LEMME A,REDSHAW M S,et al.The effects of supplemental guanidino acetic acid as a precursor of creatine in vegetable broiler diets on performance and carcass parameters[J].Poultry Science,2008,87:72-72.



[30] OSTOJIC S M.Cellular bioenergetics of guanidinoacetic acid:the role of mitochondria[J].Journal of Bioenergetics & Biomembranes,2015,47(5):369-372.  



[31] 洑琴,乔丽红,唐志刚,等.胍基乙酸对建鲤生产性能、体成分及肌肉能量代谢关键酶的影响[J].中国粮油学报,2015,30(3):85-89.



[32] 李洁蕾,郝月,顾宪红.胍基乙酸对保育猪生长性能、抗氧化能力和糖代谢关键酶的影响[J].动物营养学报,2017(10):2773-2780.



[33] MICHIELS J,MAERTENS L,BUYSE J,et al.Supplementation of guanidinoacetic acid to broiler diets:effects on performance,carcass characteristics,meat quality,and energy metabolism[J].Poultry Science,2012,91(2):402-412.  



[34] CASEY A,GREENHAFF P L.Does dietary creatine supplementation play a role in skeletal muscle metabolism and performance?[J].The American Journal of Clinical Nutrition,2000,72(2):607S-617S.



[35] 孙正武.磷酸肌酸通过调节线粒体氧化磷酸化对抗脂多糖诱导的人脐静脉细胞凋亡[D].硕士学位论文.大连:大连医科大学,2014.



[36] WANG L S,SHI B M,SHAN A S,et al.Effects of guanidinoacetic acid on growth performance,meat quality and antioxidation in growing-finishing pigs[J].Journal of Animal and Veterinary Advances,2012,11(5):631-636.  



[37] 李洁蕾,郝月,崔艳军,等.胍基乙酸的代谢过程及其在畜禽生产中的作用[C]//中国畜牧兽医学会动物福利与健康养殖分会成立大会暨首届规模化健康与福利养猪高峰学术论坛论文集.泰安:中国畜牧兽医学会动物福利与健康养殖分会筹委会,2015.



[38] LAWLER J M,BARNES W S,WU G Y,et al.Direct antioxidant properties of creatine[J].Biochemical and Biophysical Research Communications,2002,290(1):47-52.  



[39] GUIDI C,POTENZA L,SESTILI P,et al.Differential effect of creatine on oxidatively-injured mitochondrial and nuclear DNA[J].Biochimica et Biophysica Acta(BBA)-General Subjects,2008,1780(1):16-26.  



[40] 赵力,李琦,李午生,等.磷酸肌酸对阿霉素致大鼠心肌损伤的保护作用及其抗细胞凋亡的实验研究[J].中国医学工程,2011,19(8):5-8,14.



[41] WU G,MEININGER C J.Arginine nutrition and cardiovascular function (Reprinted from vol 130,pg 2626,2000)[J].Journal of Nutrition,2002,132(Suppl.12):2626-2629.



[42] LEMME A,RINGEL J,STERK A,et al.Supplemental guanidino acetic acid affects energy metabolism of broilers[C]//Proceedings of the 16th European symposium on poultry nutrition,[S.l.]:[s.n.],2007:339-342.



[43] MOUSAVI S N,AFSAR A,LOTFOLLAHIAN H.Effects of guanidinoacetic acid supplementation to broiler diets with varying energy contents[J].The Journal of Applied Poultry Research,2013,22(1):47-54.  



[44] 江涛.胍基乙酸的合成及其对肉鸡生长性能和血液理化指标的影响[D].硕士毕业论文.合肥:安徽农业大学,2012:1-41



[45] 王欢,王为雄,汪宏云,等.胍基乙酸在育肥猪中应用效果研究[J].粮食与饲料工业,2015,12(3):47-49.



[46] 张德福,李易明,田耀耀,等.胍基乙酸对猪生长性能和饲养经济效益的影响[J].中国饲料,2016(18):29-31,35.



[47] 潘宝海,孙冬岩,田耀耀.胍基乙酸对育肥猪生长性能、胴体品质及肉品质的影响[J].中国畜牧杂志,2016,52(19):38-41.



[48] BAKER D H.Advances in protein-amino acid nutrition of poultry[J].Amino Acids,2009,37(1):29-41.  



[49] EMAMI N M,GOLIAN A,RHOADS D D,et al.Interactive effects of temperature and dietary supplementation of arginine or guanidinoacetic acid on nutritional and physiological responses in male broiler chickens[J].British Poultry Science,2017,58(1):87-94.  



[50] EDISON E E,BROSNAN M E,MEYER C,et al.Creatine synthesis:production of guanidinoacetate by the rat and human kidney in vivo[J].American Journal of Physiology-Renal Physiology,2007,293(6):F1799-F1804.



[51] 王亚琼,刘强,姜发彬,等.胍基乙酸对樱桃谷肉鸭生产性能和抗氧化能力的影响[J].南京农业大学学报,2016,39(2):269-274.



[52] 祁永旺,王昕陟,侯华,等.胍基乙酸对育肥猪生产性能和胴体品质的影响[J].黑龙江畜牧兽医,2011(6):65-66.



[53] 刘洋,李蛟龙,张林,等.胍基乙酸和甜菜碱对育肥猪肌肉能量代谢和肉品质的影响[J].畜牧兽医学报,2015,46(9):1557-1563.



[54] 陈政宽,张俊玲,田耀耀,等.胍基乙酸对育肥猪胴体性状和肉品质的影响[J].饲料博览,2017(12):18-21.



[55] RAHMAN M S,AL-FARSI S A.Instrumental texture profile analysis (TPA) of date flesh as a function of moisture contene[J].Journal of Food Engineering,2005,66(4):505-511.  



[56] SCHEFFLER T L,GERRARD D E.Mechanisms controlling pork quality development:the biochemistry controlling postmortem energy metabolism[J].Meat Science,2007,77(1):7-16.  
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