The object of this experiment was to investigate the effects of zinc methionine and vitamin A on growth performance and intestinal function of small intestinal front section of weaned piglets. A repetitive factorial design with two factors and three levels was used. A total of 81 "Duroc×Landrace×Large White" three-way hybrid piglets with a similar weaning weight of (7.22±0.61) kg at the age of 28 days were selected and randomly divided into 9 groups with 3 replicates in each group and 3 piglets in each replicate. Piglets were fed mixed diets containing 0, 300 or 400 mg/kg of zinc methionine and 0, 3 000 or 6 000 IU/kg of vitamin A, respectively. The experiment lasted for 21 days. The results showed as follows:1) dietary supplementation of vitamin A alone significantly increased the average daily gain (P<0.05) and significantly decreased the ratio of feed to weight (P<0.05). Diets supplemented with zinc methionine alone significantly increased the average daily gain (P<0.05), but had no significant effect on the ratio of feed to weight (P>0.05), and the interaction effects of zinc methionine and vitamin A had significant effects on average daily gain of piglets (P<0.05). 2) Dietary supplementation of zinc methionine and vitamin A significantly reduced the crypt depth of small intestine and increased the width and height of villus in weaned piglets (P<0.05), and the interaction effect was more significant (P<0.05). Dietary zinc methionine or vitamin A alone significantly increased intestinal disaccharide activities (P<0.05), and the interaction effect was even more pronounced (P<0.05). In conclusion, the results suggest that dietary zinc methionine at 400 mg/kg and vitamin A at 6 000 IU/kg can achieve the best growth performance of weaned piglets, and the interaction has more significant effects on the average daily gain of piglets. Zinc methionine and vitamin A have significant effects on improving morphology of small intestinal front section and enhancing intestinal disaccharide activities of piglets.