The objective of this study was to investigate the effects of sanguinarine (SAG) and Achyranthes bidentata polysaccharides (ABP) on growth performance and immune performance of yellow-feather broilers alone or in combination. Three hundred 1-day-old yellow-feather broilers were randomly divided into 5 groups with 6 replicates per group and 10 broilers per replicates. The broilers in control group were fed a basal diet, the broilers in SAG group were fed the basal diet supplemented with 0.75 mg/kg SAG, the broilers in ABP group were fed the basal diet supplemented with 400 mg/kg ABP, the broilers in SAG+ABP group were fed the basal diet supplemented with 0.75 mg/kg SAG and 400 mg/kg ABP, and the broilers in antibiotic group were fed the basal diet supplemented with 300 mg/kg bacitracin zinc. The whole trial period was 56 days and it was divided into two phases (1 to 28 days of age and 29 to 56 days of age). The results showed as follows:1) the experimental treatment had significant effects on the average feed intake and average daily gain of yellow-feather broilers at 1 to 28 days of age and 29 to 56 days of age and the feed/gain of yellow-feather broilers at 1 to 28 days of age (P<0.05). The average feed intake and average daily gain of yellow-feather broilers at 29 to 56 days of age in the SAG, ABP and SAG+ABP groups were significantly higher than those in the control and antibiotics groups (P<0.05). SAG and ABP had a significant interaction effect on the average feed intake of yellow-feather broilers at 1 to 28 days of age and 29 to 56 days of age (P<0.05). 2) The lymphocyte proliferation rate in peripheral blood of yellow-feather broilers at 28 days of age in the SAG, ABP and SAG+ABP groups were significantly higher than those in the control and antibiotics groups (P<0.05). The lymphocyte proliferation rate in peripheral blood of yellow-feather broilers at 28 days of age in the SAG+ABP group was the highest, which was significantly higher than that in the control, SAG and antibiotics groups (P<0.05), but no significant difference was found between ABP and SAG+ABP groups (P>0.05). SAG and ABP had a significant interaction effect on the lymphocyte proliferation rate in peripheral blood of yellow-feather broilers at 28 days of age (P<0.05). 3) At 28 days of age, SAG and/or ABP supplementation increased the immune organ indexes of yellow-feather broilers at a certain extent compared with the control group (P>0.05), and there was no significant interaction effect of SAG and ABP on immune organ indexes (P>0.05). It is concluded that SAG and ABP can promote the growth and enhance the body immunity of yellow-feather broilers, and they have certain interaction effects on growth performance and lymphocyte proliferation rate in peripheral blood.