Effects of &alpha;-Lipoic Acid on Growth Performance, Antioxidant and Immunity of Sheep under Heat Stress

ZHANG Hongrui, GAO Yan, YAN Lingmin, YANG Gaiqing, WANG Linfeng, FU Tong, LIAN Hongxia, GAO Tengyun, LI Ming

doi:10.3969/j.issn.1006-267x.2019.04.033

Chinese Journal of Animal Nutrition >

2019 , Vol. 31 >Issue 4: 1754 - 1764

DOI: https://doi.org/10.3969/j.issn.1006-267x.2019.04.033

Molecular Nutrition

Effects of α-Lipoic Acid on Growth Performance, Antioxidant and Immunity of Sheep under Heat Stress

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1. Key Laboratory of Animal Biochemistry and Nutrition of Ministry of Agriculture, College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China;
2. Advanced Experimental Techniques and Managing Centre, Henan Agricultural University, Zhengzhou 450002, China

Received date: 2018-09-25

Online published: 2019-04-16

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Abstract

The aim of this study was to investigate the effects of α-lipoic acid (α-LA) on the growth performance, antioxidant and immunity of sheep under heat stress, in order to elucidate the mechanism of its anti-heat stress. Fifteen sheep aged 4 to 5 months and bodyweight between 35 to 40 kg were randomly selected, and equally divided into three groups:control group (CTL), low-dose group (LA-L, supplemented with 600 mg/kg α-LA) and high-dose group (LA-H, supplemented with 900 mg/kg α-LA), and animals fed under heat stress (7 to 8 months) for 40 d. The results showed as follows:1) compared with control group, average daily feed intake in α-LA group increased, and that in low-dose group and high-dose group increased by 7.3% and 2.7% (P>0.05); serum alanine aminotransferase, aspartate aminotransferase activities in high-dose group, malonaldehyde, tumor necrosis factor-α, interleukin-1β, interleukin-8 in α-LA group significantly decreased (P<0.05); the plasma contents of triiodothyronine, heat shock protein 70, immunoglobulin G, and superoxide dismutase activity in α-LA group significantly increased (P<0.05). 2) Compared with control group, the mRNA expression levels of inflammatory cytokines interleukin-1β, interleukin-8, nuclear factor-κB significantly decreased (P<0.05), and the mRNA expression levels of anti-inflammatory cytokine interferon-γ significantly increased (P<0.05). To sum up, α-LA significantly enhances the antioxidant capacity of sheep under heat stress, decreases the expression of inflammatory factors, and improves the expression of anti-inflammatory factors and immune function; the effect is related to the dosage of α-LA.

Key words： α-lipoic acid; heat stress; biochemical indexes; immune; anti-oxidation; inflammatory factors; sheep

Cite this article

ZHANG Hongrui, GAO Yan, YAN Lingmin, YANG Gaiqing, WANG Linfeng, FU Tong, LIAN Hongxia, GAO Tengyun, LI Ming . Effects of α-Lipoic Acid on Growth Performance, Antioxidant and Immunity of Sheep under Heat Stress[J]. Chinese Journal of Animal Nutrition, 2019 , 31(4) : 1754 -1764 . DOI: 10.3969/j.issn.1006-267x.2019.04.033

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