Molecular Nutrition

Study on Application Effect and Mechanism of Taurine and Glutamine Combination in Early-Weaned Piglets Diets

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  • Key Laboratory for Bio-Feed and Molecular Nutrition, College of Animal Science and Technology, Southwest University, Chongqing 400715, China

Received date: 2018-08-20

  Online published: 2019-04-16

Abstract

The purpose of this experiment was to investigate the effects of taurine (Tau) instead of partial glutamine (Gln) on growth performance, serum parameters, intestinal mucosal morphology and expression of intestinal damage repair related genes of early-weaned piglets. Forty early-weaned piglets were randomly divided into 4 groups:control group (1.0% Gln), group Ⅰ (0.1% Tau+0.4% Gln), group Ⅱ (0.1% Tau+0.6% Gln) and group Ⅲ (0.1%Tau+0.8%Gln). The feeding trial lasted for 21 days including a pre-test period of 3 days. The results showed that compared with the control group, the average daily gain in groups Ⅰ, Ⅱ and Ⅲ increased by 4.96% (P<0.05), 12.84% (P<0.05) and 7.54% (P<0.05), the daily feed intake increased by 1.14% (P>0.05), 4.33% (P<0.05) and 1.28% (P>0.05), and the feed/gain decreased by 4.64% (P<0.05), 8.25% (P<0.05) and 6.19% (P<0.05), respectively. The daily average net profit of early-weaned pigs supplemented with 0.1% Tau instead of 0.6%, 0.4% and 0.2% Gln increased by 30% (P<0.05), 42% (P<0.05) and 26% (P<0.05), respectively. Liver index, thymus index, jejunal weight index and ileal weight index in group Ⅱ were significantly higher than those in other groups (P<0.05). Serum albumin concentration in groups Ⅱ and Ⅲ was significantly higher than that in control group and group Ⅰ (P<0.05). Compared with the control group, serum aspartate aminotransferase activity in groups Ⅰ, Ⅱ and Ⅲ was significantly decreased (P<0.05). Serum alkaline phosphatase activity in group Ⅱ was significantly higher than that in other groups (P<0.05). Serum triglyceride concentration in groups Ⅱ and Ⅲ was significantly lower than that in control group and group Ⅰ (P<0.05). Serum catalase activity in group Ⅱ was significantly higher than that in other groups (P<0.05). Serum superoxide anion free radical scavenging ability and total antioxidant capacity in group Ⅱ were significantly higher than those in control group (P<0.05). Compared with the control group, serum superoxide dismutase activity in groups Ⅰ, Ⅱ and Ⅲ was significantly increased (P<0.05). Compared with the control group, the concentrations of serum essential amino acids (EAA) such as lysine (Lys), methionine (Met), arginine (Arg), cysteine (Cys), histidine (His), isoleucine (Ile), phenylalanine (Phe), valine (Val) and threonine (Thr) increased to different extents, and the concentrations of serum non-essential amino acids (NEAA) such as alanine (Ala), aspartic acid (Asp), glutamic acid (Glu) and glycine (Gly) also increased to varying degrees. The ileum villus height in groups Ⅰ, Ⅱ and Ⅲ was significantly higher than that in control group (P<0.05). The relative expression level of β-catenin gene in group Ⅱ was significantly lower than that in control group (P<0.05). It is concluded that the effect of adding Tau and Gln in the diet of early-weaned piglets is better than that of Gln alone, and the best effect is obtained by replacing 0.4% Gln with 0.1% Tau (group Ⅱ).

Cite this article

LU Changwen, ZHANG Xiaolong, HU Hong, CHEN Qingju, TANG Zhiru . Study on Application Effect and Mechanism of Taurine and Glutamine Combination in Early-Weaned Piglets Diets[J]. Chinese Journal of Animal Nutrition, 2019 , 31(4) : 1919 -1929 . DOI: 10.3969/j.issn.1006-267x.2019.04.052

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