Research Progresses on Nutrition Metabolism and Physiological Function of Uridine Monophosphate

LI Biao, WU Xin, ZHANG Bin, YIN Yulong

doi:10.3969/j.issn.1006-267x.2019.06.006

Chinese Journal of Animal Nutrition >

2019 , Vol. 31 >Issue 6: 2487 - 2494

DOI: https://doi.org/10.3969/j.issn.1006-267x.2019.06.006

Molecular Nutrition

Research Progresses on Nutrition Metabolism and Physiological Function of Uridine Monophosphate

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1. Hunan Co-Innovation Center of Safety Animal Production, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China;
2. Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410125, China

Received date: 2018-11-21

Online published: 2019-06-17

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Abstract

Uridine monophosphate is the most abundant nucleotide among the five nucleotides (uridine monophosphate, cytidine monophosphate, inosine monophosphate, guanosine monophosphate and adenosine monophosphate) in sow's milk, and it is more than 90% of total nucleotides in sow's milk. Compared with the sow's milk, the content of uridine monophosphate in creep feeds is the most lacking, and this phenomenon is evident especially in the early weaning stage. Therefore, uridine monophosphate may play important roles in the normal growth and development of piglets. As a basic pyrimidine nucleotide compound, uridine monophosphate has very important physiological functions. This paper reviews the structure, absorption and metabolism, biological functions, metabolism relationship with three major nutrients and potential application in animal production and so on, aims to providing reference for single nucleotide supplementation to diets for animals and single nucleotide nutrition.

Key words： uridine monophosphate; pyrimidine nucleotide; metabolism; function; growth and development; piglets

Cite this article

LI Biao, WU Xin, ZHANG Bin, YIN Yulong . Research Progresses on Nutrition Metabolism and Physiological Function of Uridine Monophosphate[J]. Chinese Journal of Animal Nutrition, 2019 , 31(6) : 2487 -2494 . DOI: 10.3969/j.issn.1006-267x.2019.06.006

References

[1] HO C Y, MILLER K V, SAVAIANO D A, et al.Absorption and metabolism of orally administered purines in fed and fasted rats[J].The Journal of Nutrition, 1979, 109(8):1377-1382.

[2] TONINI B, FUSI E, RIZZI R, et al.Nucleotides in canine colostrum and milk at different stages of lactation[J].Archives of Animal Nutrition, 2010, 64(4):337-341.

[3] MATEO C D, PETERS D N, STEIN H H.Nucleotides in sow colostrum and milk at different stages of lactation[J].Journal of Animal Science, 2004, 82(5):1339-1342.

[4] MATEO C D, DAVE R I, STEIN H H.Effects of supplemental nucleosides for newly weaned pigs[J].Journal of Animal Science, 2004, 82(Suppl.2):71.

[5] 应国清, 石陆娥, 唐振兴.核苷酸类物质的应用研究进展[J].现代食品科技, 2004, 20(2):126-128, 125.

[6] ADJEI A A, JONES J T, ENRIQUEZ F J, et al.Dietary nucleosides and nucleotides reduce Cryptosporidium parvum infection in dexamethasone immunosuppressed adult mice[J].Experimental parasitology, 1999, 92(3):199-208.

[7] TSUJINAKA T, KISHIBUCHI M, ⅡJIMA S, et al.Nucleotides and intestine[J].Journal of Parenteral and Enteral Nutrition, 1999, 23(Suppl.5):S74-S77.

[8] LELEIKO N S, WALSH M J, ABRAHAM S.Gene expression in the intestine:the effect of dietary nucleotides[J].Advances in Pediatrics, 1994, 42:145-169.

[9] CARVER J D.Dietary nucleotides:cellular immune, intestinal and hepatic system effects[J].The Journal of Nutrition, 1994, 124(Suppl.1):144S-148S.

[10] PALOMBO J D, BOWERS J L, CLOUSE M E, et al.Hepatic utilization of exogenous nucleotide precursors for restoration of ATP after cold ischemia in rats[J].The American Journal of Clinical Nutrition, 1993, 57(3):420-427.

[11] LOPEZ-NAVARRO AT, GIL A, SÁNCHEZ-POZO A.Age-related effect of dietary nucleotides on liver nucleic acid content in rats[J].Annals of Nutrition and Metabolism, 1997, 41(5):324-330.

[12] CHITRA R, RANJAN-CHOUDHURY R, RAMANADHAM M.Hydrogen bonding in the neutron structure of the mononucleotide 5'-UMP disodium salt[J].Applied Physics A, 2002, 74(Suppl.1):s1576-s1578.

[13] COSGROVE M.Perinatal and infant nutrition.Nucleotides[J].Nutrition, 1998, 14(10):748-751.

[14] BOZA J.Nucleotides in infant nutrition[J].Monatsschrift Kinderheilkunde, 1998, 146(Suppl.1):S39-S48.

[15] CHU S.Nucleotides:biochemistry and metabolism[J].Seminars in Pediatric Gastroenterology and Nutrition, 1991, 2:6-11.

[16] CARVER J D, ALLAN WALKER W.The role of nucleotides in human nutrition[J].The Journal of Nutritional Biochemistry, 1995, 6(2):58-72.

[17] UAUY R.Dietary nucleotides and requirements in early life[M]//LEBENTHAL E.Textbook of gastroenterology and nutrition in infancy.New York:Raven Press, 1989:265-280.

[18] SAVAIANO D A, CLIFFORD A J.Adenine, the precursor of nucleic acids in intestinal cells unable to synthesize purines de novo[J].The Journal of Nutrition, 1981, 101(10):1816-1822.

[19] GIL A, UAUY R.Nucleotides and related compounds in human and bovine milks[M]//JENSEN R G.Handbook of milk composition.San Diego:Academic Press, Inc, 1995:436-464.

[20] SANDERSON I R, HE Y.Nucleotide uptake and metabolism by intestinal epithelial cells[J].The Journal of Nutrition, 1994, 124(Suppl.1):131S-137S.

[21] QUAN R, UAUY R.Nucleotides and gastrointestinal development[J].Seminars in Pediatric Gastroenterology and Nutrition, 1991, 2:3-6.

[22] MORLEY D J, HAWLEY D M, ULBRIGHT T M, et al.Distribution of phosphodiesterase Ⅰ in normal human tissues[J].Journal of Histochemistry & Cytochemistry, 1987, 35(1):75-82.

[23] WEICKMANN J L, ELSON M, GLITZ D G.Purification and characterization of human pancreatic ribonuclease[J].Biochemistry, 1981, 20(5):1272-1278.

[24] HOLDSWORTH G, COLEMAN R.Enzyme profiles of mammalian bile[J].Biochimica et Biophysica Acta:Biomembranes, 1975, 389(1):47-50.

[25] BRONK J R, HASTEWELL J G.The transport of pyrimidines into tissue rings cut from rat small intestine[J].The Journal of Physiology, 1987, 382(1):475-488.

[26] SONODA T, TATIBANA M.Metabolic fate of pyrimidines and purines in dietary nucleic acids ingested by mice[J].Biochimica et Biophysica Acta:Nucleic Acids and Protein Synthesis, 1978, 521(1):55-66.

[27] SCHWENK M, HEGAZY E, DEL PINO V L.Uridine uptake by isolated intestinal epithelial cells of guinea pig[J].Biochimica et Biophysica Acta:Molecular Cell Research, 1984, 805(4):370-374.

[28] CARTER-SU C, KIMMICH G A.Membrane potentials and sugar transport by ATP-depleted intestinal cells:effect of anion gradients[J].The American Journal of Physiology, 1979, 237(1):C67-C74.

[29] A.瓦尔基.糖生物学基础[M].树政译.北京:科学出版社, 2003.

[30] 乔宾福.微生物产生核苷和核酸[J].工业微生物, 1998, 28(1):22-27.

[31] 周世业.外源核苷酸对断奶仔猪生长性能和抗氧化功能影响的研究[D].硕士学位论文.福州:福建农林大学, 2008.

[32] TORRES-LÍPEZ M, FERNANDEZ I, FONTANA L, et al.Influence of dietary nucleotides on liver structural recovery and hepatocyte binuclearity in cirrhosis induced by thioacetamide[J].Gut, 1996, 38(2):260-264.

[33] 王兰芳, 乐国伟, 施用晖, 等.日粮核苷酸对早期断奶小鼠生长发育的影响[J].无锡轻工大学学报, 2003, 22(4):18-22.

[34] RAMIREZ M, HORTELANO P, BOZA J Jr, et al.Effect of dietary nucleotides and orotate on the blood levels of prostacyclin (PGI₂) and thromboxane (TXA₂) in the weanling rat[J].Prostaglandins, Leukotrienes and Essential Fatty Acids, 1991, 43(1):49-54.

[35] BOZA J, JIMENEZ J, FAUS M J, et al.Influences of postnatal age and dietary nucleotides on plasma fatty acids in the weanling rat[J].Journal of Parenteral and Enteral Nutrition, 1992, 16(4):322-326.

[36] BAILEY C J.Orotic aciduria and uridine monophosphate synthase:a reappraisal[J].Journal of Inherited Metabolic Disease, 2009, 32(Suppl.1):227-233.

[37] CANSEV M, WATKINS C J, VAN DER BEEK E M, et al.Oral uridine-5'-monophosphate (UMP) increases brain CDP-choline levels in gerbils[J].Brain Research, 2005, 1058(1-2):101-108.

[38] LE T T, ZIEMBA A, URASAKI Y, et al.Disruption of uridine homeostasis links liver pyrimidine metabolism to lipid accumulation[J].Journal of Lipid Research, 2013, 54(4):1044-1057.

[39] CARVER J D, STROMQUIST C I.Dietary nucleotides and preterm infant nutrition[J].Journal of Perinatology, 2006, 26(7):443-444.

[40] KULKARNI A D, FANSLOW W C, RUDOLPH F B, et al.Effect of dietary nucleotides on response to bacterial infections[J].Journal of Parenteral and Enteral Nutrition, 1986, 10(2):169-171.

[41] JURÁNEK I, BEZEK S.Controversy of free radical hypothesis:reactive oxygen species-cause or consequence of tissue injury?[J].General Physiology and Biophysics, 2005, 24(3):263-278.

[42] JYONOUCHI H, SUN S N, WINSHIP T, et al.Dietary ribonucleotides modulate type 1 and type 2 T-helper cell responses against ovalbumin in young BALB/cJ mice[J].The Journal of Nutrition, 2001, 131(4):1165-1170.

[43] GRIMBLE G K, WESTWOOD O M.Nucleotides as immunomodulators in clinical nutrition[J].Current Opinion in Clinical Nutrition and Metabolic Care, 2001, 4(1):57-64.

[44] 杨玉芬, 周世业, 乔建国.外源5'-尿苷酸对断奶仔猪生长性能及抗氧化能力的影响[J].西北农林科技大学学报(自然科学版), 2009, 37(5):49-52, 58.

[45] 周杰, 高吉刚.新的核苷衍生物N², N₃-亚乙烯基腺嘌呤核苷的合成[J].有机化学, 2004, 24(5):498-501.

[46] LI B, ZHOU H, WU X, et al.Effects of dietary supplementation with uridine monophosphate on performance and intestinal morphology of weanling piglets[J].Journal of Animal Science, 2016, 94(Suppl.3):82-86.

[47] 张海明, 林可椒.单核苷酸等纯化学制剂对鳖的诱食效果[J].淡水渔业, 2003, 33(6):20-22.

[48] TSUJINAKA T, KISHIBUCHI M, ⅡJIMA S, et al.Nucleotides and intestine[J].Journal of Parenteral and Enteral Nutrition, 1999, 23(Suppl.5):S74-S77.

[49] UAUY R, STRINGEL G, THOMAS R, et al.Effect of dietary nucleosides on growth and maturation of the developing gut in the rat[J].Journal of Pediatric Gastroenterology and Nutrition, 1990, 10(4):497-503.

[50] PEREZ-PARDO P, DODIYA H B, BROERSEN L M, et al.Gut-brain and brain-gut axis in Parkinson's disease models:effects of a uridine and fish oil diet[J].Nutritional Neuroscience, 2018, 21(6):391-402.

[51] 蓝汉冰, 曹俊明, 李国立, 等.饲料中添加不同类型核苷酸对凡纳滨对虾生长性能的影响[J].现代渔业信息, 2009, 24(6):3-5.

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