Molecular Nutrition

Pro-Inflammatory and Indicative Effects of Prostaglandins and Their Receptors in Chronic Inflammation in Animals

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  • 1. State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    2. Key Laboratory of Dairy Nutrition in Beijing, Beijing University of Agriculture, Beijing 102206, China

Received date: 2018-12-04

  Online published: 2019-06-17

Abstract

Chronic inflammation of animals is the basis of a variety of chronic diseases, including chronic mastitis, metabolic syndrome, arthritis, wound infections, vascular diseases and cancer. Prostaglandins (PGs), as a typical acute inflammatory mediator, have also been shown to play an important role in the transition and maintenance of chronic inflammation including:1) cytokine signal transduction amplification; 2) promote acquired immunity and induce long-term immune inflammation; 3) recruit inflammatory cells; 4) participate in tissue remodeling. Therefore, PGs signaling may be a therapeutic target for chronic inflammation. Due to the impact of chronic inflammation on animal health and the importance of PGs in chronic inflammation in animals, this review summarized the classification of PGs and their receptors and the characteristics of PGs as a typical acute inflammatory mediator, focused on the pro-inflammatory effect of PGs in the chronic inflammation and the indicative effect of prostaglandin-H2 D-isomerase (PTGDS) and lipocalin-type prostaglandin D synthetase (L-PGDS) in chronic mastitis in dairy cows.

Cite this article

WANG Yue, XUE Fuguang, JIANG Linshu, XIONG Benhai . Pro-Inflammatory and Indicative Effects of Prostaglandins and Their Receptors in Chronic Inflammation in Animals[J]. Chinese Journal of Animal Nutrition, 2019 , 31(6) : 2495 -2501 . DOI: 10.3969/j.issn.1006-267x.2019.06.007

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