[1] YUN C H,ESTRADA A,VAN KESSEL A,et al.β-glucan,extracted from oat,enhances disease resistance against bacterial and parasitic infections[J].FEMS Immunology & Medical Microbiology,2003,35(1):67-75.

[2] AGUILAR-USCANGA B,FRANÇOIS J M.A study of the yeast cell wall composition and structure in response to growth conditions and mode of cultivation[J].Letters in Applied Microbiology,2003,37(3):268-274.

[3] SAMUELSEN A B C,SCHREZENMEIR J,KNUTSEN S H.Effects of orally administered yeast-derived beta-glucans:a review[J].Molecular Nutrition & Food Research,2014,58(1):183-193.

[4] LESAGE G,BUSSEY H.Cell wall assembly in Saccharomyces cerevisiae[J].Microbiology and Molecular Biology Reviews,2006,70(2):317-343.

[5] WILLIAMS D L,MCNAMEE R B,JONES E L,et al.A method for the solubilization of a (1→3)-β-D-glucan isolated from Saccharomyces cerevisiae[J].Carbohydrate Research,1991,219:203-213.
[6] LIU Q Y,DUAN B C,XU X J,et al.Progress in rigid polysaccharide-based nanocomposites with therapeutic functions[J].Journal of Materials Chemistry B,2017,5(29):5690-5713.

[7] LØKKA G,FALK K,AUSTBØ L,et al.Uptake of yeast cells in the Atlantic salmon (Salmo salar L.) intestine[J].Developmental & Comparative Immunology,2014,47(1):77-80.

[8] VALLEJOS-VIDAL E,REYES-LÍPEZ F,TELES M,et al.The response of fish to immunostimulant diets[J].Fish & Shellfish Immunology,2016,56:34-69.
[9] DENNEHY K M,BROWN G D.The role of the β-glucan receptor Dectin-1 in control of fungal infection[J].Journal of Leukocyte Biology,2007,82(2):253-258.

[10] XIA Y,ROSS G D.Generation of recombinant fragments of CD11b expressing the functional β-glucan-binding lectin site of CR3(CD11b/CD18)[J].The Journal of Immunology,1999,162(12):7285-7293.
[11] THOMPSON I J,OYSTON P C,WILLIAMSON D E.Potential of the β-glucans to enhance innate resistance to biological agents[J].Expert Review of Anti-infective Therapy,2010,8(3):339-352.

[12] GOODRIDGE H S,WOLF A J,UNDERHILL D M.β-glucan recognition by the innate immune system[J].Immunological Reviews,2009,230(1):38-50.

[13] VERESCHAGIN E I,VAN LAMBALGEN A A,DUSHKIN M I,et al.Soluble glucan protects against endotoxin shock in the rat:the role of the scavenger receptor[J].Shock,1998,9(3):193-198.

[14] BENARD E L,ROOBOL S J,SPAINK H P,et al.Phagocytosis of mycobacteria by zebrafish macrophages is dependent on the scavenger receptor Marco,a key control factor of pro-inflammatory signalling[J].Developmental & Comparative Immunology,2014,47(2):223-233.

[15] FINK I R,BENARD E L,HERMSEN T,et al.Molecular and functional characterization of the scavenger receptor CD36 in zebrafish and common carp[J].Molecular Immunology,2015,63(2):381-393.

[16] PIETRETTI D,VERA-JIMENEZ N I,HOOLE D,et al.Oxidative burst and nitric oxide responses in carp macrophages induced by zymosan,MacroGard and selective Dectin-1 agonists suggest recognition by multiple pattern recognition receptors[J].Fish & Shellfish Immunology,2013,35(3):847-857.

[17] ALCORN S W,MURRAY A L,PASCHO R J.Effects of rearing temperature on immune functions in sockeye salmon (Oncorhynchus nerka)[J].Fish & Shellfish Immunology,2002,12(4):303-334.

[18] DÍAZ-ROSALES P,MUÑOZ-ATIENZA E,TAFALLA C.Role of teleost B cells in viral immunity[J].Fish & Shellfish Immunology,2019,86:135-142.
[19] 曹雪涛.医学免疫学[M].6版.北京:人民卫生出版社,2013:119-128.
[20] SILVA M T,CORREIA-NEVES M.Neutrophils and macrophages:the main partners of phagocyte cell systems[J].Frontiers in Immunology,2012,3:174.
[21] PETIT J,WIEGERTJES G F.Long-lived effects of administering β-glucans:indications for trained immunity in fish[J].Developmental & Comparative Immunology,2016,64:93-102.
[22] SÁNCHEZ-MARTÍNEZ J G,RÁBAGO-CASTRO J L,DE LA LUZ VÁZQUEZ-SAUCEDA M,et al.Effect of β-glucan dietary levels on immune response and hematology of channel catfish Ictalurus punctatus juveniles[J].Latin American Journal of Aquatic Research,2017,45(4):690-698.

[23] GUZMÁN-VILLANUEVA L T,TOVAR-RAMÍREZ D,GISBERT E,et al.Dietary administration of β-1,3/1,6-glucan and probiotic strain Shewanella putrefaciens,single or combined,on gilthead seabream growth,immune responses and gene expression[J].Fish & Shellfish Immunology,2014,39(1):34-41.

[24] DO HUU H,SANG H M,THANH THUY N T.Dietary β-glucan improved growth performance,Vibrio counts,haematological parameters and stress resistance of pompano fish,Trachinotus ovatus Linnaeus,1758[J].Fish & Shellfish Immunology,2016,54:402-410.
[25] MAGNADÍTTIR B.Innate immunity of fish (overview)[J].Fish & Shellfish Immunology,2006,20(2):137-151.

[26] DUNKELBERGER J R,SONG W C.Complement and its role in innate and adaptive immune responses[J].Cell Research,2010,20(1):34-50.

[27] AI Q H,MAI K S,ZHANG L,et al.Effects of dietary β-1,3 glucan on innate immune response of large yellow croaker,Pseudosciaena crocea[J].Fish & Shellfish Immunology,2007,22(4):394-402.

[28] EL-BOSHY M E,EL-ASHRAM A M,ABDELHAMID F M,et al.Immunomodulatory effect of dietary Saccharomyces cerevisiae,β-glucan and laminaran in mercuric chloride treated Nile tilapia (Oreochromis niloticus) and experimentally infected with Aeromonas hydrophila[J].Fish & Shellfish Immunology,2010,28(5/6):802-808.
[29] DAWOOD M A O,KOSHIO S,EL-SABAGH M,et al.Changes in the growth,humoral and mucosal immune responses following β-glucan and vitamin C administration in red sea bream,Pagrus major[J].Aquaculture,2017,470:214-222.
[30] CHETTRI J K,KANIA P W,BUCHMANN K.Immunomodulation of rainbow trout (Oncorhynchus mykiss) fry by bath exposure to a β-glucan from Euglena gracilis[J].Aquaculture Research,2013,44(9):1407-1415.

[31] PIONNIER N,FALCO A,MIEST J,et al.Dietary β-glucan stimulate complement and C-reactive protein acute phase responses in common carp (Cyprinus carpio) during an Aeromonas salmonicida infection[J].Fish & Shellfish Immunology,2013,34(3):819-831.

[32] PIONNIER N,FALCO A,MIEST J J,et al.Feeding common carp Cyprinus carpio with β-glucan supplemented diet stimulates C-reactive protein and complement immune acute phase responses following PAMPs injection[J].Fish & Shellfish Immunology,2014,39(2):285-295.

[33] LOKESH J,FERNANDES J M O,KORSNES K,et al.Transcriptional regulation of cytokines in the intestine of Atlantic cod fed yeast derived mannan oligosaccharide or β-glucan and challenged with Vibrio anguillarum[J].Fish & Shellfish Immunology,2012,33(3):626-631.

[34] FALCO A,FROST P,MIEST J,et al.Reduced inflammatory response to Aeromonas salmonicida infection in common carp (Cyprinus carpio L.) fed with β-glucan supplements[J].Fish & Shellfish Immunology,2012,32(6):1051-1057.

[35] FALCO A,MIEST J J,PIONNIER N,et al.β-glucan-supplemented diets increase poly (I:C)-induced gene expression of Mx,possibly via TLR3-mediated recognition mechanism in common carp (Cyprinus carpio)[J].Fish & Shellfish Immunology,2014,36(2):494-502.

[36] MIEST J J,ARNDT C,ADAMEK M,et al.Dietary β-glucan (MacroGard) enhances survival of first feeding turbot (Scophthalmus maximus) larvae by altering immunity,metabolism and microbiota[J].Fish & Shellfish Immunology,2016,48:94-104.
[37] BISWAS G,KORENAGA H,TAKAYAMA H,et al.Cytokine responses in the common carp,Cyprinus carpio L. treated with baker's yeast extract[J].Aquaculture,2012,356-357:169-175.
[38] SIRIMANAPONG W,THOMPSON K D,OOI E L,et al.The effects of feeding β-glucan to Pangasianodon hypophthalmus on immune gene expression and resistance to Edwardsiella ictaluri[J].Fish & Shellfish Immunology,2015,47(1):595-605.

[39] JIANG C Y,WANG P,LI M Y,et al.Dietary β-glucan enhances the contents of complement component 3 and factor B in eggs of zebrafish[J].Developmental & Comparative Immunology,2016,65:107-113.
[40] WANG P,JIANG C Y,LIU S S,et al.Trans-generational enhancement of C-type lysozyme level in eggs of zebrafish by dietary β-glucan[J].Developmental & Comparative Immunology,2017,74:25-31.
[41] LAZADO C C,CAIPANG C M A.Mucosal immunity and probiotics in fish[J].Fish & Shellfish Immunology,2014,39(1):78-89.

[42] ROMBOUT J H W M,YANG G W,KIRON V.Adaptive immune responses at mucosal surfaces of teleost fish[J].Fish & Shellfish Immunology,2014,40(2):634-643.

[43] PARRA D,REYES-LOPEZ F E,TORT L.Mucosal immunity and B cells in teleosts:effect of vaccination and stress[J].Frontiers in Immunology,2015,6:354.
[44] DALMO R A,BØGWALD J.β-glucans as conductors of immune symphonies[J].Fish & Shellfish Immunology,2008,25(4):384-396.

[45] SCHMITT P,WACYK J,MORALES-LANGE B,et al.Immunomodulatory effect of cathelicidins in response to a β-glucan in intestinal epithelial cells from rainbow trout[J].Developmental & Comparative Immunology,2015,51(1):160-169.

[46] KIRON V,KULKARNI A,DAHLE D,et al.Recognition of purified beta 1,3/1,6 glucan and molecular signalling in the intestine of Atlantic salmon[J].Developmental & Comparative Immunology,2016,56:57-66.
[47] SWENNEN K,COURTIN C M,DELCOUR J A.Non-digestible oligosaccharides with prebiotic properties[J].Critical Reviews in Food Science and Nutrition,2006,46(6):459-471.

[48] KVHLWEIN H,EMERY M J,RAWLING M D,et al.Effects of a dietary β-(1,3)(1,6)-D-glucan supplementation on intestinal microbial communities and intestinal ultrastructure of mirror carp (Cyprinus carpio L.)[J].Journal of Applied Microbiology,2013,115(5):1091-1106.

[49] JUNG-SCHROERS V,ADAMEK M,JUNG A,et al.Feeding of β-1,3/1,6-glucan increases the diversity of the intestinal microflora of carp (Cyprinus carpio)[J].Aquaculture Nutrition,2016,22(5):1026-1039.

[50] CARDA-DIÉGUEZ M,MIRA A,FOUZ B.Pyrosequencing survey of intestinal microbiota diversity in cultured sea bass (Dicentrarchus labrax) fed functional diets[J].FEMS Microbiology Ecology,2014,87(2):451-459.

[51] KAWASHIMA T,KOSAKA A,YAN H M,et al.Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-β[J].Immunity,2013,38(6):1187-1197.

[52] 石纪奎,李永富,史锋.机械活化酿酒酵母葡聚糖改善其水溶性[J].食品与生物技术学报,2015,34(5):536-541.
[53] PENGKUMSRI N,SIVAMARUTHI B S,SIRILUN S,et al.Extraction of β-glucan from Saccharomyces cerevisiae:comparison of different extraction methods and in vivo assessment of immunomodulatory effect in mice[J].Food Science and Technology,2017,37(1):124-130.
[54] LIU X Y,WANG Q,CUI S W,et al.A new isolation method of β-D-glucans from spent yeast Saccharomyces cerevisiae[J].Food Hydrocolloids,2008,22(2):239-247.