Molecular Nutrition

Physiological Role of Circulating Exosomes on Hepatic Lipid Metabolism Disorder in Ketosis Dairy Cows

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  • College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China

Received date: 2018-12-04

  Online published: 2019-07-19

Abstract

Dairy cows ketosis is caused by negative energy balance and is a common metabolic disorder in perinatal period. The exosomes are a class of vesicles containing membrane proteins, blocked cytoplasmic proteins and RNA, which can transmit information to regulate the physiological state of the body cells. This article reviewed that circulating exosomes exert an influence on liver lipid metabolism in dairy cows, regulate adenosine 5'-monophosphate-activated protein kinase α/silencing signal regulator 1 (AMPKα-SIRT1) pathway, and act as diagnostic markers for hepatic lipid metabolism disorders in ketosis cows. To sum up, this review of the current research status is helpful to explore the repairing effect and mechanism of circulating exosomes on hepatic lipid metabolism disorder in ketosis cows, and provides theoretical and practical basis for finding suitable targeted drugs for ketosis.

Cite this article

HUANG Yingying, LIU Leihong, WU Jinjie, LI Yu . Physiological Role of Circulating Exosomes on Hepatic Lipid Metabolism Disorder in Ketosis Dairy Cows[J]. Chinese Journal of Animal Nutrition, 2019 , 31(7) : 3004 -3008 . DOI: 10.3969/j.issn.1006-267x.2019.07.009

References

[1] VIÑA C,FOUZ R,CAMINO F,et al.Study on some risk factors and effects of bovine ketosis on dairy cows from the Galicia region (Spain)[J].Journal of Animal Physiology and Animal Nutrition,2017,101(5):835-845.  

[2] MARQUÉS-GARCÍA F,ISIDORO-GARCÍA M.Protocols for exosome isolation and RNA profiling[J].Methods in Molecular Biology,2016,1434:153-167.

[3] TKACH M,THÉRY C.Communication by extracellular vesicles:where we are and where we need to go[J].Cell,2016,164(6):1226-1232.  

[4] THÉRY C,ZITVOGEL L,AMIGORENA S.Exosomes:composition,biogenesis and function[J].Nature Reviews Immunology,2002,2(8):569-579.  

[5] KOECK E S,IORDANSKAIA T,SEVILLA S,et al.Adipocyte exosomes induce transforming growth factor beta pathway dysregulation in hepatocytes:a novel paradigm for obesity-related liver disease[J].Journal of Surgical Research,2014,192(2):268-275.  

[6] NOJIMA H,FREEMAN C M,SCHUSTER R M,et al.Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate[J].Journal of Hepatology,2016,64(1):60-68.  

[7] ZHOU Y,WANG X,SUN L,et al.Toll-like receptor 3-activated macrophages confer anti-HCV activity to hepatocytes through exosomes[J].The FASEB Journal,2016,30(12):4132-4140.  

[8] HUBER H J,HOLVOET P.Exosomes:emerging roles in communication between blood cells and vascular tissues during atherosclerosis[J].Current Opinion in Lipidology,2015,26(5):412-419.  

[9] DENG Z B,POLIAKOV A,HARDY R W,et al.Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance[J].Diabetes,2009,58(11):2498-2505.  

[10] FERRANTE S C,NADLER E P,PILLAI D K,et al.Adipocyte-derived exosomal miRNAs:a novel mechanism for obesity-related disease[J].Pediatric Research,2015,77(3):447-454.  

[11] LEE Y S,KIM S Y,KO E,et al.Exosomes derived from palmitic acid-treated hepatocytes induce fibrotic activation of hepatic stellate cells[J].Scientific Reports,2017,7(1):3710.

[12] LEWIS A P,JOPLING C L.Regulation and biological function of the liver-specific miR-122[J].Biochemical Society Transactions,2010,38(6):1553-1557.  

[13] BARANOVA A,MALTSEVA D,TONEVITSKY A.Adipose may actively delay progression of NAFLD by releasing tumor-suppressing,anti-fibrotic miR-122 into circulation[J].Obesity Reviews,2019,20(1):108-118.  

[14] ZHANG Y,YU M,TIAN W D.Physiological and pathological impact of exosomes of adipose tissue[J].Cell Proliferation,2016,49(1):3-13.  

[15] HARDIE D G.The AMP-activated protein kinase cascade:the key sensor of cellular energy status[J].Endocrinology,2003,144(12):5179-5183.  

[16] VIOLLET B,FORETZ M,GUIGAS B,et al.Activation of AMP-activated protein kinase in the liver:a new strategy for the management of metabolic hepatic disorders[J].The Journal of Physiology,2006,574(1):41-53.  

[17] LONG Y C,ZIERATH J R.AMP-activated protein kinase signaling in metabolic regulation[J].The Journal of Clinical Investigation,2006,116(7):1776-1783.  

[18] CANTÍ C,GERHART-HINES Z,FEIGE J N,et al.AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity[J].Nature,2009,458(7241):1056-1060.  

[19] LIU L,JIN X,HU C F,et al.Exosomes derived from mesenchymal stem cells rescue myocardial ischaemia/reperfusion injury by inducing cardiomyocyte autophagy via AMPK and Akt pathways[J].Cellular Physiology and Biochemistry,2017,43(1):52-68.  

[20] SARAKUL O,VATTANAVIBOON P,TANAKA Y,et al.Enhanced erythroid cell differentiation in hypoxic condition is in part contributed by miR-210[J].Blood Cells,Molecules,and Diseases,2013,51(2):98-103.  

[21] 明鹏飞,黄莹莹,董妍丽,等.LKB1-AMPKα-SIRT1信号通路在奶牛脂肪组织脂代谢中的调控作用[J].生物技术通报,2019,35(2):176-181.

[22] CROOKENDEN M A,WALKER C G,PEIRIS H,et al.Short communication:proteins from circulating exosomes represent metabolic state in transition dairy cows[J].Journal of Dairy Science,2016,99(9):7661-7668.  

[23] MITCHELL M D,SCHOLZ-ROMERO K,REED S,et al.Plasma exosome profiles from dairy cows with divergent fertility phenotypes[J].Journal of Dairy Science,2016,99(9):7590-7601.  

[24] KORNEK M,SCHUPPAN D.Microparticles:modulators and biomarkers of liver disease[J].Journal of Hepatology,2012,57(5):1144-1146.  

[25] LEMOINNE S,THABUT D,HOUSSET C,et al.The emerging roles of microvesicles in liver diseases[J].Nature Reviews Gastroenterology & Hepatology,2014,11(6):350-361.  

[26] BALA S,PETRASEK J,MUNDKUR S,et al.Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic,drug-induced,and inflammatory liver diseases[J].Hepatology,2012,56(5):1946-1957.  

[27] MOMEN-HERAVI F,BALA S,KODYS K,et al.Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS[J].Scientific Reports,2015,5:9991.

[28] POVERO D,EGUCHI A,LI H Y,et al.Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver disease[J].PLoS One,2014,9(12):e113651.

[29] ZHAO K,LIANG G X,SUN X,et al.Comparative miRNAome analysis revealed different miRNA expression profiles in bovine sera and exosomes[J].BMC Genomics,2016,17(1):630.

[30] LIU Y N,LOU G H,LI A C,et al.AMSC-derived exosomes alleviate lipopolysaccharide/D-galactosamine-induced acute liver failure by miR-17-mediated reduction of TXNIP/NLRP3 inflammasome activation in macrophages[J].EBioMedicine,2018,36:140-150.
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