[1] RICHMOND V L.Incorporation of methylsulfonylmethane sulfur into guinea pig serum proteins[J].Life Sciences,1986,39(3):263-268.
[2] HERSCHLER R J.Methylsulfonylmethane and methods of use:US,US4296130[P].1981-10-20.
[3] BARRAGER E,SCHAUSS A G.Methylsulfonylmethane as a treatment for seasonal allergic rhinitis:additional data on pollen counts and symptom questionnaire[J].Journal of Alternative and Complementary Medicine,2003,9(1):15-16.
[4] COZEANC,COZEAN J,BENJAMIN R,et al.Dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) formulations to treat osteoarthritis:EP2493314[P].2012-09-05.
[5] EZAKIJ,HASHIMOTO M,HOSOKAWAY,et al.Assessment of safety and efficacy of methylsulfonylmethane on bone andknee joints in osteoarthritis animal model[J].Journal of Bone and Mineral Metabolism,2013,31(1):16-25.
[6] VAN DER MERWE M,BLOOMER R J.The influence of methylsulfonylmethane on inflammation-associated cytokine release before and following strenuous exercise[J].Journal of Sports Medicine,2016,2016:7498359.
[7] CHILDS S J.Dimethyl sulfone (DMSO2) in the treatment of interstitial cystitis[J].The Urologic Clinics of North America,1994,21(1):85-88.
[8] JOUNG Y H,NA Y M,YOO Y B,et al.Combination of AG490,a Jak2 inhibitor,and methylsulfonylmethane synergistically suppresses bladder tumor growth via the Jak2/STAT3 pathway[J].International Journal of Oncology,2014,44(3):883-895.
[9] PARCELL S.Sulfur in human nutrition and applications in medicine[J].Alternative Medicine Review A,2002,7(1):22-44.
[10] LIEM D A,GHO C C,GHO B C,et al.The tyrosine phosphatase inhibitor bis(maltolato)oxovanadium attenuates myocardial reperfusion injury by opening ATP-sensitive potassium channels[J].Journal of Pharmacology and Experimental Therapeutics,2004,309(3):1256-1262.
[11] OBATA T.Adenosine production and its interaction with protection of ischemic and reperfusion injury of the myocardium[J].Life Sciences,2002,71(18):2083-2103.
[12] 刘惠芳.半胱胺、二甲基砜和天然植物提取物对肉鸭的促生长作用及其机理研究[D].博士学位论文.成都:四川农业大学,2009.
[13] LIN A,NGUY C H,SHIC F,et al.Accumulation of methylsulfonylmethane in the human brain:identification by multinuclear magnetic resonance spectroscopy[J].Toxicology Letters,2001,123(2/3):169-177.
[14] WONG T,BLOOMER R J,BENJAMIN R L,et al.Small intestinal absorption of methylsulfonylmethane (MSM) and accumulation of the sulfur moiety in selected tissues of mice[J].Nutrients,2018,10(1):E19.
[15] METGES C C,EBERHARD M,PETZKE K J.Synthesis and absorption of intestinal microbial lysine in humans and non-ruminant animals and impact on human estimated average requirement of dietary lysine[J].Current Opinion in Clinical Nutrition and Metabolic Care,2006,9(1):37-41.
[16] CARBONERO F,BENEFIEL A C,ALIZADEH-GHAMSARI A H,et al.Microbial pathways incolonic sulfur metabolism and links with health and disease[J].Frontiers in Physiology,2012,3:448.
[17] MAGNUSON B A,APPLETON J,AMES G B.Pharmacokinetics and distribution of[
35S]methylsulfonylmethane following oral administration to rats[J].Journal of Agricultural and Food Chemistry,2007,55(3):1033-1038.
[18] TOBISAWA Y,IMAI Y,FUKUDA M,et al.Sulfation of colonic mucins by N-acetylglucosamine 6-o-sulfotransferase-2 and its protective function in experimental colitis in mice[J].Journal of Biological Chemistry,2011,285(9):6750-6760.
[19] LAYMAN D L,JACOB S W.The absorption,metabolism and excretion of dimethyl sulfoxide by rhesus monkeys[J].Life Sciences,1985,37(25):2431-2437.
[20] MARAÑÍN G,MUÑOZ-ESCASSI B,MANLEY W,et al.The effect of methyl sulphonyl methane supplementation on biomarkers of oxidative stress in sport horses following jumping exercise[J].Acta Veterinaria Scandinavica,2008,50:45.
[21] BEILKE M A,COLLINS-LECH C,SOHNLE P G.Effects of dimethyl sulfoxide on the oxidative function of human neutrophils[J].Journal of Laboratory and Clinical Medicine,1987,110(1):91-96.
[22] KIM S H,SMITH A J,TAN J,et al.MSM ameliorates HIV-1 tat induced neuronal oxidative stress via rebalance of the glutathione cycle[J].American Journal of Translational Research,2015,7(2):328-338.
[23] LAWRENCE T.The nuclear factor NF-κB pathway in inflammation[J].Cold Spring Harbor Perspectives in Biology,2009,1(6):a001651.
[24] KIM Y H,KIM D H,LIM H,et al.The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages[J].Biological and Pharmaceutical Bulletin,2009,32(4):651-656.
[25] DUNN J D,ALVAREZ L A J,ZHANG X Z,et al.Reactive oxygen species and mitochondria:a nexus of cellular homeostasis[J].Redox Biology,2015,6:472-485.
[26] AHN H,KIM J,LEE M J,et al.Methylsulfonylmethane inhibits NLRP3 inflammasome activation[J].Cytokine,2015,71(2):223-231.
[27] KASTL L,SAUER S W,RUPPERT T,et al.TNF-α mediates mitochondrial uncoupling and enhances ROS-dependent cell migration via NF-κB activation in liver cells[J].FEBS Letters,2014,588(1):175-183.
[28] FU L X,LIAN Q W,PAN J D,et al.JAK2 tyrosine kinase inhibitor AG490 suppresses cell growth and invasion of gallbladder cancer cells via inhibition of JAK2/STAT3 signaling[J].Journal of Biological Regulators & Homeostatic Agents,2017,31(1):51.
[29] NIPIN S P,DARVIN P,YOO Y B,et al.The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts[J].BMC Cancer,2015,15:474.
[30] LIM E J,HONG D Y,PARK J H,et al.Methylsulfonylmethane suppresses breast cancer growth by down-regulating STAT3 and STAT5b pathways[J].PLoS One,2012,7(4):e33361.
[31] REDZA-DUTORDOIR M,AVERILL-BATES D A.Activation of apoptosis signalling pathways by reactive oxygen species[J].Biochimica et Biophysica Acta:Molecular Cell Research,2016,1863(12):2977-2992.
[32] MANEA A,TANASE L I,RAICU M,et al.Jak/STAT signaling pathway regulates nox1 and nox4-based NADPH oxidase in human aortic smooth muscle cells[J].Arteriosclerosis,Thrombosis and Vascular Biology,2010,30(1):105-112.
[33] GROSS A.BCL-2 family proteins as regulators of mitochondria metabolism[J].Biochimica et Biophysica Acta:Bioenergetics,2016,1857(8):1243-1246.
[34] LIU D P,XU Y.p53,oxidative stress,and aging[J].Antioxidants & Redox Signaling,2011,15(6):1669-1678.
[35] KARABAY A Z,AKTAN F,SUNGURO ?LU A,et al.Methylsulfonylmethane modulates apoptosis of LPS/IFN-γ-activated RAW 264.7 macrophage-like cells by targeting p53,Bax,Bcl-2,cytochromec and PARP proteins[J].Immunopharmacology & Immunotoxicology,2014,36(6):379-389.
[36] POMERANTZ J L,BALTIMORE A D.Two pathways to NF-κB[J].Molecular Cell,2002,10(4):693-695.
[37] JOUNG Y H,DARVIN P,KANG D Y,et al.Methylsulfonylmethane inhibits RANKL-induced osteoclastogenesis in BMMs by suppressing NF-κB and STAT3 activities[J].PLoS One,2016,11(7):e0159891.
[38] OSHIMA Y,AMIEL D,THEODOSAKIS J.213 the effect of distilled methylsulfonylmethane (MSM) on human chondrocytes in vitro[J].Osteoarthritis and Cartilage,2007,15(15):C123.
[39] TOUSOULIS D,KAMPOLI A M,COSTAS T N P,et al.The role of nitric oxide on endothelial function[J].Current Vascular Pharmacology,2012,10(1):4-18.
[40] COLEMAN J W.Nitric oxide:a regulator of mast cell activation and mast cell-mediated inflammation[J].Clinical & Experimental Immunology,2010,129(1):4-10.
[41] HE Y,HARA H,NÙÑEZ G.Mechanism and regulation of NLRP3 inflammasome activation[J].Trends in Biochemical Sciences,2016,41(12):1012-1021.
[42] MARTINON F.Detection of immune danger signals by NALP3[J].Journal of leukocyte Biology,2008,83(3):507-511.
[43] 余伟,祝曙光,陆少君,等.二甲基砜对小鼠抗炎作用及免疫功能的影响[J].海南医学院学报,2018,24(9):899-901.
[44] AMIRSHAHROKHI K,BOHLOOLI S,CHINIFROUSH M M.The effect of methylsulfonylmethane on the experimental colitis in the rat[J].Toxicology and Applied Pharmacology,2011,253(3):197-202.
[45] KARABAY A Z,KOC A,OZKAN T,et al.Methylsulfonylmethane induces p53 independent apoptosis in hct-116 colon cancer cells[J].International Journal of Molecular Sciences,2016,17(7):1123.
[46] CARON J M,MONTEAGUDO L,SANDERS M,et al.Methyl sulfone manifests anticancer activity in a metastatic murine breast cancer cell line and in human breast cancer tissue-part 2:human breast cancer tissue[J].Chemotherapy,2013,59(1):24-34.
[47] SP N,DARVIN P,YOO Y B,et al.The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts[J].BMC Cancer,2015,15:474.
[48] JAFARI N,BOHLOOLI S,MOHAMMADI S,et al.Cytotoxicity of methylsulfonylmethane on gastrointestinal (AGS,HepG2,and KEYSE-30) cancer cell lines[J].Journal of Gastrointestinal Cancer,2012,43(3):420-425.
[49] KIM J H,SHIN H J,HA H L,et al.Methylsulfonylmethane suppresses hepatic tumor development through activation of apoptosis[J].World Journal of Hepatology,2014,6(2):98-106.
[50] KARABAY A Z,KOCA,OZKAN T,et al.Methylsulfonylmethane induces p53 independent apoptosis in hct-116 colon cancer cells[J].International Journal of Molecular Sciences,2016,17(7):1123.
[51] PARK D J,THOMAS N J,YOON C,et al.Vascular endothelial growth factor a inhibition in gastric cancer[J].Gastric Cancer,2015,18(1):33-42.
[52] CARON M I,CARON M I.Methyl sulfone blocked multiple hypoxia-and non-hypoxia-induced metastatic targets in breast cancer cells and melanoma cells[J].PLoS One,2015,10(11):e0141565.
[53] WITHEE E D,TIPPENS K M,DEHEN R,et al.Effects of methylsulfonylmethane (MSM) on exercise-induced oxidative stress,muscle damage,and pain following a half-marathon:a double-blind,randomized,placebo-controlled trial[J].Journal of the International Society of Sports Nutrition,2017,14:24.
[54] KAUFMANNS H,HENGARTNER M O.Programmed cell death:alive and well in the new millennium[J].Trends in Cell Biology,2001,11(12):526-534.
[55] NAGY G,SZARKA A,LOTZ G,et al.BGP-15 inhibits caspase-independent programmed cell death in acetaminophen-induced liver injury[J].Toxicology and Applied Pharmacology,2010,243(1):96-103.
[56] RAMOUTAR R R,BRUMAGHIM J L.Antioxidant and anticancer properties and mechanisms of inorganic selenium,oxo-sulfur,and oxo-selenium compounds[J].Cell Biochemistry and Biophysics,2010,58(1):1-23.
[57] MORTON J I,SIEGEL B V.Effects of oral dimethyl sulfoxide and dimethyl sulfone on murine autoimmune lymphoproliferative disease[J].Experimental Biology and Medicine,1986,183(2):227-230.
[58] CHO J H,MIN B J,KWON O S,et al.Effects of MSM (methyl sulfonyl methane) supplementation on growth performance and digestibility of Ca and N in pigs[J].Journal of the Korean Society of Food Science and Nutrition,2005,34(3):361-365.
[59] 范京辉.MSM对肉鸡生长及脂肪代谢影响[C].//第十四届全国家禽科学学术讨论会论文集.哈尔滨:中国畜牧兽医学会,2009:4.
[60] 刘惠芳,周安国.植物提取物、半胱胺和二甲基砜对肉鸭生产性能和屠宰性能的影响[J].天然产物研究与开发,2008,20(2):302-306.
[61] 严梦,刘惠芳,王之盛,等.天然植物提取物、半胱胺和二甲基砜对肉鸭生长性能和屠宰性能的影响[J].四川农业大学学报,2006,24(4):439-443.
[62] BENJAMIN R LVARELMAN J,KELLER A L.Use of methylsulfonylmethane(MSM)to modulate inhibit microbial activity:US,20130065967[P].2013-03-14.
[63] JIAO Y,PARK J H,KIM Y M,et al.Effects of dietary methyl sulfonyl methane (MSM) supplementation on growth performance,nutrient digestibility,meat quality,excreta microbiota,excreta gas emission,and blood profiles in broilers[J].Poultry Science,2017,96(7):2168-2175.
