This experiment aimed to investigate the effects of catalase (CAT) supplementation in diets of sows during late gestation and lactation on reproductive performance, antioxidant capacity and digestibility of sows and piglets' growth performance and antioxidant capacity. In experiment, a total of 160 healthy crossbred sows (Landrace×Yorkshire) were used and randomly divided into 4 groups (control group, test A group, test B group and test C group), with the supplementation of CAT at 0, 50, 100 and 150 U/kg, respectively, and each group had 40 sows with 1 sow per replicate. The experiment started from day 90 of pregnancy to weaning of piglets. The results showed that compared with the control group, the supplementation of CAT increased the number of total piglets born, number of born alive, number of born healthy and birth litter weight of piglets but did not reach the significant level (P>0.05). Adding CAT in sows' diets had a significant effect on decreasing the diarrhea rates of piglets (P<0.05); at day 104 of pregnancy, compared with the control group, the serum total antioxidant capacity (T-AOC) in test groups B and C increased by 60.03% and 53.70% (P<0.05), respectively. The activity of CAT in serum in test B group was higher than that in control group, test groups A and C (P<0.05). At day 14 of lactation, compared with the control group, the activity of CAT in serum in test B group significantly increased (P<0.05); compared with the control group, T-AOC in colostrums in test C group increased by 119.10% (P<0.05). Compared with control group A, the activity of CAT in colostrums in test groups B and C increased by 86.24% and 76.95% (P<0.05); all test groups had significant differences in the crude fat and ether extract digestibility compared with control group (P<0.05). The results show that adding CAT in the diet of pregnant sow can improve the number of total birth piglets, T-AOC, GSH content and CAT activity of serum at day 104 of pregnancy and day 14 of lactation, and the T-AOC and CAT activity in colostrum; the sow antioxidant capacity improves the most when 100 U/kg CAT added to the sow diets; adding CAT in the sow diets can significantly improve the digestibility of crude fat and ether extract.