Molecular Nutrition

Effects of Birth Weight on Liver Development and Lipid Metabolism of Meishan Newborn Piglets

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  • College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China

Received date: 2019-01-06

  Online published: 2019-07-19

Abstract

The study aimed to determine the effects of birth weight on liver development and lipid metabolism of Meishan newborn piglets. Six normal birth weight (NBW) and six low birth weight (LBW) Meishan newborn piglets were selected without breast milk feeding and killed by jugular artery bloodletting within 6 hours of birth. Blood of piglets were taken to determine plasma lipid metabolism indexes, liver organ index, liver lipid metabolism indexes and related genes expression were measured after killed and sampled. The results showed as follows:compared with NBW group, liver cell diameter and area of Meishan newborn piglets in LBW group were significantly decreased (P<0.01); the content of total cholesterol (TC) in plasma was significantly increased (P<0.01), the content of low density lipoprotein (LDL) in plasma was significantly increased (P<0.05), and the content of triglyceride (TG) in plasma was significantly decreased (P<0.01); the content of TC in liver was significantly decreased (P<0.05), the content of TG and the activity of lipoprotein lipase (LPL) in liver were significantly decreased (P<0.01), and the activity of hepatic lipase (HL) in liver showed a downward trend (P=0.086); the gene expression levels of fatty acid synthase (FAS) and LPL in liver were significantly decreased (P<0.01), and the gene expression level of hormone-sensitive lipase (HSL) in liver was significantly decreased (P<0.05). In conclusion, LBW can inhibit liver improvement and decrease lipid metabolism function of Meishan newborn piglets.

Cite this article

ZHONG Zhaoxin, DONG Li, MAO Junzhou, ZHANG Yongsheng, YU Lihuai . Effects of Birth Weight on Liver Development and Lipid Metabolism of Meishan Newborn Piglets[J]. Chinese Journal of Animal Nutrition, 2019 , 31(7) : 3391 -3397 . DOI: 10.3969/j.issn.1006-267x.2019.07.053

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