Research Advance on Antimicrobial Peptide Expression Regulated by Histone Deacetylase in Intestines

  • YI Hongbo ,
  • WANG Li ,
  • XIONG Yunxia ,
  • JIANG Zongyong
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  • State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science in South China Ministry of Agriculture, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China

Received date: 2019-03-29

  Online published: 2019-10-17

Abstract

Antimicrobial peptides (AMPs) showed functions of antibacterial activity, immunomodulation and improving intestinal mucosal barriers. Given low intestinal immunity of weaned piglets, AMPs play key roles in the intestinal epithelium against pathogens invasion. However, it is difficulty to effectively improve the AMPs expression and not to cause intestinal inflammation during nutritional regulation of intestinal immunity in weaned piglets. Histone deacetylase (HDAC) inhibitors precisely enhanced the AMPs expression by modulating histone modifications in the promoter region of the AMPs genes. Therefore, HDAC were important targets for the regulation of intestinal AMPs expression. In this paper, we reviewed the biological functions of AMPs, and mechanisms of AMPs expression regulated by histone modification and HDAC. In addition, we summarized possible mechanisms of AMPs expression regulated by nutrients via HDAC. The aim of this paper is to provide theoretical guidance for nutritional regulation of AMPs expression and improvement of intestinal immunity in weaned piglets.

Cite this article

YI Hongbo , WANG Li , XIONG Yunxia , JIANG Zongyong . Research Advance on Antimicrobial Peptide Expression Regulated by Histone Deacetylase in Intestines[J]. Chinese Journal of Animal Nutrition, 2019 , 31(10) : 4421 -4426 . DOI: 10.3969/j.issn.1006-267x.2019.10.002

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