Research Advances in Regulation of &omega;-3 Polyunsaturated Fatty Acids in Milk

HUANG Guoxin; ZHANG Yangdong; ZHENG Nan; WANG Jiaqi

doi:10.3969/j.issn.1006-267x.2019.11.003

Chinese Journal of Animal Nutrition >

2019 , Vol. 31 >Issue 11: 4917 - 4926

DOI: https://doi.org/10.3969/j.issn.1006-267x.2019.11.003

Research Advances in Regulation of ω-3 Polyunsaturated Fatty Acids in Milk

HUANG Guoxin ,
ZHANG Yangdong ,
ZHENG Nan ,
WANG Jiaqi

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1. Ministry of Agriculture Laboratory of Quality&Safety Risk Assessment for Dairy Products(Beijing), Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193;
2. State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193;
3. College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030

Received date: 2019-04-27

Online published: 2019-11-19

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Abstract

Milk is rich in nutrients and has gradually become a part of human diet. Milk containing varied kinds of ω-3 polyunsaturated fatty acids. The ω-3 polyunsaturated fatty acids are essential fatty acids for human body, which play a vital role in maintaining the health of human. Therefore, exploring the regulation mechanism of ω-3 polyunsaturated fatty acids in milk is conducive to improve the content of ω-3 polyunsaturated fatty acids in milk, and further improving the nutritional value of milk. This article reviewed factors that affecting the enrichment of ω-3 polyunsaturated fatty acids in milk, including feed, rumen biohydrogenation, transport of mammary gland cells, parity and lactation period of dairy cows.

Key words： milk; ω-3 polyunsaturated fatty acids; nutritional value; rumen biohydrogenation; mammary gland

Cite this article

HUANG Guoxin , ZHANG Yangdong , ZHENG Nan , WANG Jiaqi . Research Advances in Regulation of ω-3 Polyunsaturated Fatty Acids in Milk[J]. Chinese Journal of Animal Nutrition, 2019 , 31(11) : 4917 -4926 . DOI: 10.3969/j.issn.1006-267x.2019.11.003

References

[1] ALTOMONTE I,SALARI F,LICITRA R,et al.Use of microalgae in ruminant nutrition and implications on milk quality-a review[J].Livestock Science,2018,214:25-35.
[2] SHEN P Y,KERSHAW J C,YUE Y R,et al.Effects of conjugated linoleic acid (CLA) on fat accumulation,activity,and proteomics analysis in Caenorhabditis elegans[J].Food Chemistry,2018,249:193-201.
[3] KABEYA N,FONSECA M M,FERRIER D,et al.Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals[J].Science Advances,2018,4(5):eaar6849.
[4] SAINI R K,KEUM Y S.Omega-3 and omega-6 polyunsaturated fatty acids:dietary sources,metabolism,and significance-a review[J].Life Sciences,2018,203:255-267.
[5] AL-GHANNAMI S S,AL-ADAWI S,GHEBREMESKEL K,et al.Randomised open-label trial of docosahexaenoic acid-enriched fish oil and fish meal on cognitive and behavioural functioning in Omani children[J].Nutrition,2019,57:167-172.
[6] SUN S X,HUA X M,DENG Y Y,et al.Tracking pollutants in dietary fish oil:from ocean to table[J].Environmental Pollution,2018,240:733-744.
[7] VOORSPOELS S,COVACI A,NEELS H.Dietary PCB intake in Belgium[J].Environmental Toxicology and Pharmacology,2008,25(2):179-182.

[8] KAIRENIUS P,ÄRÄLÄ A,LESKINEN H,et al.Dietary fish oil supplements depress milk fat yield and alter milk fatty acid composition in lactating cows fed grass silage-based diets[J].Journal of Dairy Science,2015,98(8):5653-5671.

[9] MORAN C A,MORLACCHINI M,KEEGAN J D,et al.The effect of dietary supplementation with Aurantiochytrium limacinum on lactating dairy cows in terms of animal health,productivity and milk composition[J].Journal of Animal Physiology and Animal Nutrition,2018,102(2):576-590.

[10] SINEDINO L D P,HONDA P M,SOUZA L R L,et al.Effects of supplementation with docosahexaenoic acid on reproduction of dairy cows[J].Reproduction,2017,153(5):707-723.

[11] RESENDE T L,KRAFT J,SODER K J,et al.Incremental amounts of ground flaxseed decrease milk yield but increase n-3 fatty acids and conjugated linoleic acids in dairy cows fed high-forage diets[J].Journal of Dairy Science,2015,98(7):4785-4799.

[12] BRITO A F,PETIT H V,PEREIRA A B D,et al.Interactions of corn meal or molasses with a soybean-sunflower meal mix or flaxseed meal on production,milk fatty acid composition,and nutrient utilization in dairy cows fed grass hay-based diets[J].Journal of Dairy Science,2015,98(1):443-457.

[13] PIRONDINI M,COLOMBINI S,MELE M,et al.Effect of dietary starch concentration and fish oil supplementation on milk yield and composition,diet digestibility,and methane emissions in lactating dairy cows[J].Journal of Dairy Science,2015,98(1):357-372.

[14] SALIBA L,GERVAIS R,LEBEUF Y,et al.Effect of feeding linseed oil in diets differing in forage to concentrate ratio:1.Production performance and milk fat content of biohydrogenation intermediates of α-linolenic acid[J].Journal of Dairy Research,2014,81(1):82-90.

[15] MOATE P J,WILLIAMS S R O,HANNAH M C,et al.Effects of feeding algal meal high in docosahexaenoic acid on feed intake,milk production,and methane emissions in dairy cows[J].Journal of Dairy Science,2013,96(5):3177-3188.

[16] VAHMANI P,FREDEEN A H,GLOVER K E.Effect of supplementation with fish oil or microalgae on fatty acid composition of milk from cows managed in confinement or pasture systems[J].Journal of Dairy Science,2013,96(10):6660-6670.

[17] CAROPRESE M,MARZANO A,MARINO R,et al.Flaxseed supplementation improves fatty acid profile of cow milk[J].Journal of Dairy Science,2010,93(6):2580-2588.

[18] ABUGHAZALEH A A,POTU R B,IBRAHIM S.Short communication:the effect of substituting fish oil in dairy cow diets with docosahexaenoic acid-micro algae on milk composition and fatty acids profile[J].Journal of Dairy Science,2009,92(12):6156-6159.

[19] CHILLIARD Y,MARTIN C,ROUEL J,et al.Milk fatty acids in dairy cows fed whole crude linseed,extruded linseed,or linseed oil,and their relationship with methane output[J].Journal of Dairy Science,2009,92(10):5199-5211.

[20] FLOWERS G,IBRAHIM S A,ABUGHAZALEH A A.Milk fatty acid composition of grazing dairy cows when supplemented with linseed oil[J].Journal of Dairy Science,2008,91(2):722-730.

[21] WHITLOCK L A,SCHINGOETHE D J,ABUGHAZALEH A A,et al.Milk production and composition from cows fed small amounts of fish oil with extruded soybeans[J].Journal of Dairy Science,2006,89(10):3972-3980.

[22] AHNADI C E,BESWICK N,DELBECCHI L,et al.Addition of fish oil to diets for dairy cows.Ⅱ.Effects on milk fat and gene expression of mammary lipogenic enzymes[J].Journal of Dairy Research,2002,69(4):521-531.

[23] ABUGHAZALEH A A,SCHINGOETHE D J,HIPPEN A R,et al.Milk conjugated linoleic acid response to fish oil supplementation of diets differing in fatty acid profiles[J].Journal of Dairy Science,2003,86(3):944-953.

[24] KEADY T W J,MAYEN C S,FITZPATRICK D A.Effects of supplementation of dairy cattle with fish oil on silage intake,milk yield and milk composition[J].Journal of Dairy Research,2000,67(2):137-153.

[25] DONOVAN D C,SCHINGOETHE D J,BAER R J,et al.Influence of dietary fish oil on conjugated linoleic acid and other fatty acids in milk fat from lactating dairy cows[J].Journal of Dairy Science,2000,83(11):2620-2628.

[26] PI Y,GAO S T,MA L,et al.Effectiveness of rubber seed oil and flaxseed oil to enhance the α-linolenic acid content in milk from dairy cows[J].Journal of Dairy Science,2016,99(7):5719-5730.

[27] 孟庆翔.奶牛营养需要[M].北京:中国农业出大学版社,2001.
[28] MATTOS R,STAPLES C R,ARTECHE A,et al.The effects of feeding fish oil on uterine secretion of PGF_2α,milk composition,and metabolic status of periparturient Holstein cows[J].Journal of Dairy Science,2004,87(4):921-932.

[29] 陈代文,王恬.动物营养与饲养学[M].北京:中国农业出版社,2011.
[30] HEID H W,KEENAN T W.Intracellular origin and secretion of milk fat globules[J].European Journal of Cell Biology,2005,84(2/3):245-258.
[31] 黄国欣,张养东,郑楠,等.ω-3多不饱和脂肪酸对奶牛生理功能的影响及其调控机制的研究进展[J].动物营养学报,2019,31(1):43-52.
[32] NRC.Nutrient requirements of dairy cattle[S].Washington,D.C.:The National Academies Press,2001.
[33] KAIRENIUS P,LESKINEN H,TOIVONEN V,et al.Effect of dietary fish oil supplements alone or in combination with sunflower and linseed oil on ruminal lipid metabolism and bacterial populations in lactating cows[J].Journal of Dairy Science,2018,101(4):3021-3035.

[34] BEHESHTI M,CHERIAN G.Use of flaxseed in poultry feeds to meet the human need for n-3 fatty acids[J].World's Poultry Science Journal,2017,73(4):1-10.
[35] BOLGER Z,BRUNTON N P,MONAHAN F J.Impact of inclusion of flaxseed oil (pre-emulsified or encapsulated) on the physical characteristics of chicken sausages[J].Journal of Food Engineering,2018,230:39-48.
[36] SCHETTINO B,VEGA S,GUTIÉRREZ R,et al.Fatty acid profile of goat milk in diets supplemented with chia seed (Salvia hispanica L.)[J].Journal of Dairy Science,2017,100(8):6256-6265.

[37] CAROPRESE M,MANXINO R,CILIBERTI M G,et al.Fatty acid profile and coagulating ability of milk from Jersey and Friesian cows fed whole flaxseed[J].Journal of Dairy Research,2017,84(1):14-22.

[38] YANG G,BU D P,WANG J Q,et al.Duodenal infusion of α-linolenic acid affects fatty acid metabolism in the mammary gland of lactating dairy cows[J].Journal of Dairy Science,2012,95(10):5821-5830.

[39] CATTANI M,MANTOVANI R,SCHIAVON S,et al.Recovery of n-3 polyunsaturated fatty acids and conjugated linoleic acids in ripened cheese obtained from milk of cows fed different levels of extruded flaxseed[J].Journal of Dairy Science,2014,97(1):123-135.

[40] KIM K B,NAM Y A,KIM H S,et al.α-linolenic acid:nutraceutical,pharmacological and toxicological evaluation[J].Food and Chemical Toxicology,2014,70:163-178.
[41] MAHLA A S,CHAUDHARI R K,VERMA A K,et al.Effect of dietary supplementation of omega-3 polyunsaturated fatty acid (PUFA) rich fish oil on reproductive performance of the goat (Capra hircus)[J].Theriogenology,2017,99:79-89.
[42] VARGAS-BELLO-PÉREZ E,ÍÑIGUEZ-GONZÁLEZ G,FEHRMANN-CARTES K,et al.Influence of fish oil alone or in combination with hydrogenated palm oil on sensory characteristics and fatty acid composition of bovine cheese[J].Animal Feed Science and Technology,2015,205:60-68.
[43] TACON A.Use of fish meal and fish oil in aquaculture:a global perspective[J].Aquatic Resources Culture and Development,2004,1(1):3-14.
[44] RJIBA-KTITA S,CHERMITI A,BODAS R,et al.Aquatic plants and macroalgae as potential feed ingredients in ruminant diets[J].Journal of Applied Phycology,2017,29(1):449-458.

[45] LUM K K,KIM J,LEI X G.Dual potential of microalgae as a sustainable biofuel feedstock and animal feed[J].Journal of Animal Science and Biotechnology,2014,4:53.
[46] STAMEY J A,SHEPHERD D M,DE VETH M J,et al.Use of algae or algal oil rich in n-3 fatty acids as a feed supplement for dairy cattle[J].Journal of Dairy Science,2012,95(9):5269-5275.

[47] RYCKEBOSCH E,BRUNEEL C,TERMOTE-VERHALLE R,et al.Nutritional evaluation of microalgae oils rich in omega-3 long chain polyunsaturated fatty acids as an alternative for fish oil[J].Food Chemistry,2014,160:393-400.
[48] BERNAL-SANTOS G,O'DONNELL A M,VICINI J L,et al.Hot topic:enhancing omega-3 fatty acids in milk fat of dairy cows by using stearidonic acid-enriched soybean oil from genetically modified soybeans[J].Journal of Dairy Science,2010,93(1):32-37.

[49] LOURENÇO M,RAMOS-MORALES E,WALLACE R J.The role of microbes in rumen lipolysis and biohydrogenation and their manipulation[J].Animal,2010,4(7):1008-1023.

[50] MAIA M R G,CHAUDHARY L C,FIGUERES L,et al.Metabolism of polyunsaturated fatty acids and their toxicity to the microflora of the rumen[J].Antonie van Leeuwenhoek,2007,91(4):303-314.

[51] SHINGFIELD K J,LEE M R,HUMPHRIES D J,et al.Effect of linseed oil and fish oil alone or as an equal mixture on ruminal fatty acid metabolism in growing steers fed maize silage-based diets[J].Journal of Animal Science,2011,89(11):3728-3741.

[52] MAIA M R,CHAUDHARY L C,BESTWICK C S,et al.Toxicity of unsaturated fatty acids to the biohydrogenating ruminal bacterium,Butyrivibrio fibrisolvens[J].BMC Microbiology,2010,10:52.
[53] SHINGFIELD K J,KAIRENIUS P,ÄRÖLÄ A,et al.Dietary fish oil supplements modify ruminal biohydrogenation,alter the flow of fatty acids at the omasum,and induce changes in the ruminal Butyrivibrio population in lactating cows[J].The Journal of Nutrition,2012,142(8):1437-1448.

[54] SCHAFFER J E,LODISH H F.Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein[J].Cell,1994,79(3):427-436.

[55] COBURN C T,KNAPP F F,Jr,FEBBRAIO M,et al.Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice[J].Journal of Biological Chemistry,2000,275(42):32523-32529.

[56] POHL J,RING A,HERRMANN T,et al.New concepts of cellular fatty acid uptake:role of fatty acid transport proteins and of caveolae[J].Proceedings of the Nutrition Society,2004,63(2):259-262.

[57] STOOP W M,BOVENHUIS H,HECK J M L,et al.Effect of lactation stage and energy status on milk fat composition of Holstein-Friesian cows[J].Journal of Dairy Science,2009,92(4):1469-1478.

[58] KELSEY J A,CORL B A,COLLIER R J,et al.The effect of breed,parity,and stage of lactation on conjugated linoleic acid (CLA) in milk fat from dairy cows[J].Journal of Dairy Science,2003,86(8):2588-2597.

[59] KAY J K,WEBER W J,MOORE C E,et al.Effects of week of lactation and genetic selection for milk yield on milk fatty acid composition in Holstein cows[J].Journal of Dairy Science,2005,88(11):3886-3893.

[60] 卜登攀.日粮不饱和脂肪酸对乳脂共轭亚油酸(CLA)合成的影响及其机理[D].博士学位论文.北京:中国农业科学院,2006.
[61] SAMKOVÁ E,KOUBOVÁ J,HASONOVA L,et al.Joint effects of breed,parity,month of lactation,and cow individuality on the milk fatty acids composition[J].Mljekarstvo,2018,68(2):98-107.
[62] ARTEGOITIA V,MEIKLE A,OLAZABAL L,et al.Milk casein and fatty acid fractions in early lactation are affected by nutritional regulation of body condition score at the beginning of the transition period in primiparous and multiparous cows under grazing conditions[J].Journal of Animal Physiology and Animal Nutrition,2013,97(5):919-932.

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