[1] PACHECO-PALENCIA L A,MERTENS-TALCOTT S,TALCOTT S T.Chemical composition,antioxidant properties,and thermal stability of a phytochemical enriched oil from açai (
Euterpe oleracea Mart.)[J].Journal of Agricultural and Food Chemistry,2008,56(12):4631-4636.

[2] 尚海花,王淼,刘颖,等.HPLC法测定不同产地刺五加中原儿茶酸、紫丁香苷、绿原酸、刺五加苷E和异嗪皮啶[J].现代药物与临床,2018,33(6):1324-1328.
[3] SZOPA A,KOKOTKIEWICZ A,BEDNARZ M,et al.Studies on the accumulation of phenolic acids and flavonoids in different
in vitro culture systems of
Schisandra chinensis (Turcz.) Baill.Using a DAD-HPLC method[J].Phytochemistry Letters,2017,20:462-469.
[4] YIN M C,LIN C C,WU H C,et al.Apoptotic effects of protocatechuic acid in human breast,lung,liver,cervix,and prostate cancer cells:potential mechanisms of action[J].Journal of Agricultural and Food Chemistry,2009,57(14):6468-6473.

[5] 吴道勋,刘璐,王莹,等.云南松松塔中原儿茶酸提取工艺的研究[J].大理学院学报,2014,13(4):4-6,7.
[6] 邓毅,宁红霞,沈薇,等.HPLC同时测定雪松松针中没食子酸、原儿茶酸和儿茶素的含量[J].中国现代应用药学,2014,31(9):1104-1107.
[7] DE FERRARS R M,CZANK C,ZHANG Q,et al.The pharmacokinetics of anthocyanins and their metabolites in humans[J].British Journal of Pharmacology,2014,171(13):3268-3282.

[8] 胡睿智,贺宇佳,何子煜,等.矢车菊素-3-葡萄糖苷的吸收、代谢及生理功能研究进展[J].动物营养学报,2019,31(05):2052-2062.
[9] KAY C D,KROON P A,CASSIDY A.The bioactivity of dietary anthocyanins is likely to be mediated by their degradation products[J].Molecular Nutrition & Food Research,2009,53(Suppl.1):S92-S101.
[10] KAKKAR S,BAIS S.A review on protocatechuic acid and its pharmacological potential[J].ISRN Pharmacology,2014,2014:952943.
[11] 胡理乐,张海英,秦岭,等.中国五味子分布范围及气候变化影响预测[J].应用生态学报,2012,23(9):2445-2450.
[12] 程海涛,刘德江,罗志文,等.药用植物刺五加资源分布与环境因子的相关性[J].黑龙江医药科学,2012,35(4):8-9.
[13] 王效宇,陈毅烽,伍江波,等.湖南省杜仲产业现状调查[J].经济林研究,2016,34(4):158-162.
[14] REIS F S,CIRIC A,STOJKOVIC D,et al.Effects of different culture conditions on biological potential and metabolites production in three
Penicillium isolates[J].Drug Development and Industrial Pharmacy,2015,41(2):253-262.

[15] LI W S,XIE D M,FROST J W.Benzene-free synthesis of catechol:interfacing microbial and chemical catalysis[J].Journal of the American Chemical Society,2005,127(9):2874-2882.

[16] 王佳.改造木糖非磷酸化代谢途径及莽草酸途径生物合成高附加值产物[D].博士学位论文.北京:北京化工大学,2018.
[17] WU F L,CAO P,SONG G T,et al.Expanding the repertoire of aromatic chemicals by microbial production[J].Journal of Chemical Technology and Biotechnology,2018,93(10):2804-2816.

[18] SROKA Z,CISOWSKI W.Hydrogen peroxide scavenging,antioxidant and anti-radical activity of some phenolic acids[J].Food and Chemical Toxicology,2003,41(6):753-758.

[19] SHI G F,AN L J,JIANG B,et al.
Alpinia protocatechuic acid protects against oxidative damage
in vitro and reduces oxidative stress
in vivo[J].Neuroscience Letters,2006,403(3):206-210.

[20] CHOU T H,DING H Y,LIN R J,et al.Inhibition of melanogenesis and oxidation by protocatechuic acid from
Origanum vulgare (oregano)[J].Journal of Natural Products,2010,73(11):1767-1774.

[21] LI X C,WANG X Z,CHEN D F,et al.
Antioxidant activity and mechanism of protocatechuic acid
in vitro[J].Functional Foods in Health & Disease,2011,1(7):232-244.
[22] ZHANG X L,SHI G F,LIU X Z,et al.Anti-ageing effects of protocatechuic acid from
Alpinia on spleen and liver antioxidative system of senescent mice[J].Cell Biochemistry & Function,2011,29(4):342-347.

[23] 王一冰.原儿茶酸影响动物肠道屏障功能的研究[D].博士学位论文.杭州:浙江大学,2017.
[24] 刘时中.自由基与衰老[J].生理科学进展,1983,14(2):147-152.
[25] VARI R,D'ARCHIVIO M,FILESI C,et al.Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages[J].The Journal of Nutritional Biochemistry,2011,22(5):409-417.

[26] CHAO C Y,YIN M C.Antibacterial effects of roselle calyx extracts and protocatechuic acid in ground beef and apple juice[J].Foodborne Pathogens and Disease,2009,6(2):201-206.

[27] 柴贝贝,姜维佳,王莉贞,等.原儿茶酸或绿原酸与抗菌药联用对鱼源链球菌的抑菌效果[J].南方农业学报,2018,49(3):580-585.
[28] PACHECO O R,WALL-MEDRANO A,GOÑI M G,et al.Effect of phenolic compounds on the growth of selected probiotic and pathogenic bacteria[J].Letters in Applied Microbiology,2018,66(1):25-31.

[29] GUTIERREZ L M,RUA J,CARO I,et al. Evaluation of antimicrobial and antioxidant activities of natural phenolic compounds against foodborne pathogens and spoilage bacteria[J].Food Control,2012,26(2):555-563.

[30] 袁胜浩,卞金辉,谢珍,等.大半边莲中酚酸类成分与抑菌活性研究[J].中成药,2013,35(01):170-172.
[31] AJIBOYE T O, HABIBU R S,SAIDU K,et al. Involvement of oxidative stress in protocatechuic acid-medi ated bacterial lethality[J].Microbiologyopen, 2017, 6(4):10.
[32] 贾振宇,孙怡,陈怡飞,等.原儿茶酸对阪崎克罗诺肠杆菌的抑制作用[J].微生物学通报,2018,45(04):788-796.
[33] LIU W H,HSU C C,YIN M C.
In vitro anti-helicobacter pylori activity of diallyl sulphides and protocatechuic acid[J].Phytotherapy Research,2008,22(1):53-57.

[34] KEMPERMAN R A,BOLCA S,ROGER L C,et al.Novel approaches for analysing gut microbes and dietary polyphenols:challenges and opportunities[J].Microbiology,2010,156(11):3224-3231.

[35] SMITH A H,ZOETENDAL E,MACKIE R I.Bacterial mechanisms to overcome inhibitory effects of dietary tannins[J].Microbial Ecology,2005,50(2):197-205.

[36] BABICH H,SCHUCK A G,WEISBURG J H,et al.Research strategies in the study of the pro-oxidant nature of polyphenol nutraceuticals[J].Journal of Toxicology,2011,2011:467305.
[37] SEMAMING Y,PANNENGPETCH P,CHATTIPAKORN S C,et al.Pharmacological properties of protocatechuic acid and its potential roles as complementary medicine[J].Evidence-Based Complementary and Alternative Medicine,2015,2015:593902.
[38] ZHANG X L,LI C L,LI J,et al.Protective effects of protocatechuic acid on acute lung injury induced by lipopolysaccharide in mice via p38MAPK and NF-κB signal pathways[J].International Immunopharmacology,2015,26(1):229-236.

[39] FAROMBI E O,ADEDARA I A,AWOYEMI O V,et al.Dietary protocatechuic acid ameliorates dextran sulphate sodium-induced ulcerative colitis and hepatotoxicity in rats[J].Food & Function,2016,7(2):913-921.

[40] NAM Y J,LEE C S.Protocatechuic acid inhibits Toll-like receptor-4-dependent activation of NF-κB by suppressing activation of the Akt,mTOR,JNK and p38-MAPK[J].International Immunopharmacology,2018,55:272-281.
[41] MASELLA R,SANTANGELO C,M.D'ARCHIVIO M,et al.Protocatechuic acid and human disease prevention:biological activities and molecular mechanisms[J].Current Medicinal Chemistry,2012,19(18):2901-2917.

[42] WANG Y M,ZHOU J,FU S,et al.Preventive effects of protocatechuic acid on LPS-induced inflammatory response in human gingival fibroblasts via activating PPAR-γ[J].Inflammation,2015,38(3):1080-1084.

[43] 刘厚佳,胡晋红,孙莲娜,等.原儿茶酸等化合物对HBV DNA转染人肝癌细胞株的作用[J].第二军医大学学报,2001,22(7):661-663.
[44] OU C B,PANG Q,CHEN X,et al.Protocatechuic acid,a new active substance against the challenge of avian infectious bursal disease virus[J].Poultry Science,2012,91(7):1604-1609.

[45] OU C B,SHI N N,YANG Q H,et al.Protocatechuic acid,a novel active substance against avian influenza virus H9N2 infection[J].PLoS One,2014,9(10):e111004.
[46] GUO Y X,ZHANG Q,ZUO Z H,et al.Protocatechuic acid (PCA) induced a better antiviral effect by immune enhancement in SPF chickens[J].Microbial Pathogenesis,2018,114:233-238.
[47] 宋雁,贾旭东,崔文明,等.不同途径和剂量环磷酰胺建立小鼠免疫抑制模型的对比研究[J].中国食品卫生杂志,2013,25(3):218-225.
[48] 欧长波,何诚.原儿茶酸对环磷酰胺诱导的肉鸡免疫抑制影响的研究[J].中国家禽,2017,39(2):28-32.
[49] OU C B,WANG Q X,WEI X B,et al.Pro-apoptosis effects of protocatechuic acid in the early stage of infectious bursal disease virus infection[J].Microbial Pathogenesis,2018,124:216-222.
[50] DAI X Q,CAI W T,WU X,et al.Protocatechuic acid inhibits hepatitis B virus replication by activating ERK1/2 pathway and down-regulating HNF4α and HNF1α
in vitro[J].Life Sciences,2017,180:68-74.
[51] 石海仁,滚双宝,张生伟,等.杜仲叶对育肥猪生长性能、胴体性状、抗氧化能力及肠道菌群的影响[J].动物营养学报,2018,30(1):350-359.
[52] 陈鹏,杨在宾,黄丽波,等.八角和杜仲叶提取物对断奶仔猪生长性能、血清酶活性及肝脏肿瘤坏死因子-α分布和表达的影响[J].动物营养学报,2017,29(3):874-881.
[53] FANG J,YAN F Y,KONG X F,et al.Dietary supplementation with
Acanthopanax senticosus extract enhances gut health in weanling piglets[J].Livestock Science,2009,123(2/3):268-275.
[54] HU R Z,HE Y J,AROWOLO M A,et al.Polyphenols as potential attenuators of heat stress in poultry production[J].Antioxidants,2019,8(3):67.