Research Progress in Wnt/β-Catenin Signaling Drives Small Intestinal Epithelial Renewal and Regeneration

  • ZHU Qiujie ,
  • ZHOU Jiayi ,
  • LIANG Shaojie ,
  • WANG Xiuqi
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  • National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China

Received date: 2019-04-16

  Online published: 2019-11-19

Abstract

Intestinal stem cells are the source of programmed renewal of small intestinal epithelium, which drive the generation of intestinal epithelial functional cells, and further realize the functions of barrier, absorption, immune and endocrine in the intestine. Meanwhile, intestinal repair after injury, namely epithelial regeneration, is also driven by intestinal stem cells. Wnt/β-catenin signaling pathway is one of the key control switches for the fate of intestinal stem cells, which can regulate their proliferation and differentiation, and maintains the ordered structure of intestinal epithelial cells and intestinal homeostasis. This paper reviews the mechanisms of Wnt/β-catenin signaling regulation in the process of intestinal epithelial renewal and regeneration, aiming to provide basis for the development of new feed additives and intestinal health management of livestock.

Cite this article

ZHU Qiujie , ZHOU Jiayi , LIANG Shaojie , WANG Xiuqi . Research Progress in Wnt/β-Catenin Signaling Drives Small Intestinal Epithelial Renewal and Regeneration[J]. Chinese Journal of Animal Nutrition, 2019 , 31(11) : 4995 -5002 . DOI: 10.3969/j.issn.1006-267x.2019.11.013

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