[1] TAN C Q,WEI H K,AO J T,et al.Inclusion of konjac flour in the gestation diet changes the gut microbiota,alleviates oxidative stress,and improves insulin sensitivity in sows[J].Applied and Environmental Microbiology,2016,82(19):5899-5909.
[2] CHENG C S,WEI H K,YU H C,et al.Metabolic syndrome during perinatal period in sows and the link with gut microbiota and metabolites[J].Frontiers in Microbiology,2018,9:1989.
[3] SHIMOBAYASHI M,ALBERT V,WOELNERHANSSEN B,et al.Insulin resistance causes inflammation in adipose tissue[J].Journal of Clinical Investigation,2018,128(4):1538-1550.
[4] SUN H Q,TAN C Q,WEI H K,et al.Effects of different amounts of konjac flour inclusion in gestation diets on physio-chemical properties of diets,postprandial satiety in pregnant sows,lactation feed intake of sows and piglet performance[J].Animal Reproduction Science,2015,152:55-64.
[5] 柒启恩,肖俊峰,张军,等.围产期母猪饲粮中添加壳寡糖对母猪、仔猪免疫功能及母猪肠道微生物的影响[J].动物营养学报,2018,30(10):4105-4122.
[6] WU R Y,MÄÄTTÄNEN P,NAPPER S,et al.Non-digestible oligosaccharides directly regulate host kinome to modulate host inflammatory responses without alterations in the gut microbiota[J].Microbiome,2017,5(1):135.
[7] 龙次民,谢春艳,吴信,等.妊娠后期母猪饲粮中添加壳寡糖对新生仔猪抗氧化能力的影响[J].动物营养学报,2015,27(4):1207-1213.
[8] 魏宏逵,周远飞,彭健.调控母猪繁殖周期中胰岛素敏感性提高繁殖性能的研究进展[C]//中国畜牧兽医学会动物营养学分会第十二次动物营养学术研讨会论文集.武汉:中国畜牧兽医学会动物营养学分会,2016.
[9] 马建华.妊娠与胰岛素抵抗[J].国外医学妇产科学分册,2005,32(1):19-22.
[10] 王蕴慧,吴惠华,丁红,等.妊娠期胰岛素抵抗及胰岛β细胞功能与体重指数、血脂水平、C反应蛋白的关系探讨[J].中华临床医师杂志(电子版),2011,5(16):4736-4740.
[11] JEFFERIES C A,HOFMAN P L,KEELAN J A,et al.Insulin resistance is not due to persistently elevated serum tumor necrosis-α levels in small for gestational age,premature,or twin children[J].Pediatric Diabetes,2004,5(1):20-25.
[12] SIVAN E,BODEN G.Free fatty acids,insulin resistance,and pregnancy[J].Current Diabetes Reports,2003,3(4):319-322.
[13] WAKI H,TONTONOZ P.Endocrine functions of adipose tissue[J].Annual Review of Pathology:Mechanisms of Disease,2007,2:31-56.
[14] YANG W S,LEE W J,FUNAHASHI T,et al.Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein,adiponectin[J].The Journal of Clinical Endocrinology & Metabolism,2001,86(8):3815-3819.
[15] OKUNO A,TAMEMOTO H,TOBE K,et al.Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats[J].The Journal of Clinical Investigation,1998,101(6):1354-1361.
[16] HEILBRONN L K,GAN S K,TURNER N,et al.Markers of mitochondrial biogenesis and metabolism are lower in overweight and obese insulin-resistant subjects[J].The Journal of Clinical Endocrinology & Metabolism,2007,92(4):1467-1473.
[17] RITOV V B,MENSHIKOVA E V,HE J,et al.Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes[J].Diabetes,2005,54(1):8-14.
[18] SHARMA N K,DAS S K,MONDAL A K,et al.Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects[J].The Journal of Clinical Endocrinology & Metabolism,2008,93(11):4532-4541.
[19] CASTILLO C,HERNANDEZ J,BRAVO A,et al.Oxidative status during late pregnancy and early lactation in dairy cows[J].The Veterinary Journal,2005,169(2):286-292.
[20] BURTON G J.The influence of the intrauterine environment on human placental development[J].Journal of Reproductive Immunology,2010,86(2):81-82.
[21] KANETO H,NAKATANI Y,KAWAMORI D,et al.Involvement of oxidative stress and the JNK pathway in glucose toxicity[J].The Review of Diabetic Studies,2004,1(4):165-174.
[22] SHEN Y B,CARROLL J A,YOON I,et al.Effects of supplementing S
accharomyces cerevisiae fermentation product in sow diets on performance of sows and nursing piglets[J].Journal of Animal Science,2011,89(8):2462-2471.
[23] TAN C Q,WEI H K,SUN H Q,et al.Effects of dietary supplementation of oregano essential oil to sows on oxidative stress status,lactation feed intake of sows,and piglet performance[J].BioMed Research International,2015,2015:525218.
[24] 陈新龙,夏照帆,韦多,等.c-Jun氨基末端激酶抑制剂减轻烫伤后胰岛素抵抗的实验研究[J].中华烧伤杂志,2006,22(6):466-468.
[25] MAURYA C K,ARHA D,RAI A K,et al.NOD2 activation induces oxidative stress contributing to mitochondrial dysfunction and insulin resistance in skeletal muscle cells[J].Free Radical Biology and Medicine,2015,89:158-169.
[26] BÄCKHED F,DING H,WANG T,et al.The gut microbiota as an environmental factor that regulates fat storage[J].Proceedings of the National Academy of Sciences of the United States of America,2004,101(44):15718-15723.
[27] XIONG Y M,MIYAMOTO N,SHIBATA K,et al.Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41[J].Proceedings of the National Academy of Sciences of the United States of America,2004,101(4):1045-1050.
[28] MATTACE RASO G,SIMEOLI R,RUSSO R,et al.Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high fat diet[J].PLoS One,2013,8(7):e68626.
[29] KUMAR H,KAWAI T,AKIRA S.Toll-like receptors and innate immunity[J].Biochemical and Biophysical Research Communications,2009,388(4):621-625.
[30] CARICILLI A M,PICARDI P K,DE ABREU L L,et al.Retraction:gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice[J].PLoS Biology,2016,14(5):e1002479.
[31] D'AVERSA F,TORTORA A,IANIRO G,et al.Gut microbiota and metabolic syndrome[J].Internal and Emergency Medicine,2013,8(Suppl.1):11-15.
[32] SCHERTZER J D,TAMRAKAR A K,MAGALHÃES J G,et al.NOD1 activators link innate immunity to insulin resistance[J].Diabetes,2011,60(9):2206-2215.
[33] CAPITÁN-CANADAS F,ORTEGA-GONZÁLEZ M,GUADIX E,et al.Prebiotic oligosaccharides directly modulate proinflammatory cytokine production in monocytes via activation of TLR4[J].Molecular Nutrition & Food Research,2014,58(5):1098-1110.
[34] JIAO L F,KE Y L,XIAO K,et al.Effects of cello-oligosaccharide on intestinal microbiota and epithelial barrier function of weanling pigs[J].Journal of Animal Science,2015,93(3):1157-1164.
[35] BHATIA S,PRABHU P N,BENEFIEL A C,et al.Galacto-oligosaccharides may directly enhance intestinal barrier function through the modulation of goblet cells[J].Molecular Nutrition & Food Research,2015,59(3):566-573.
[36] SPILJAR M,MERKLER D,TRAJKOVSKI M.The immune system bridges the gut microbiota with systemic energy homeostasis:focus on TLRs,mucosal barrier,and SCFAs[J].Frontiers in Immunology,2017,8:1353.
[37] 杨开云.壳寡糖对母猪早期胎儿生长和繁殖性能的影响及机理研究[D].硕士学位论文.雅安:四川农业大学,2016.
[38] FERNÁNDEZ J,REDONDO-BLANCO S,GUTIÉRREZ-DEL-RÍO I,et al.Colon microbiota fermentation of dietary prebiotics towards short-chain fatty acids and their roles as anti-inflammatory and antitumour agents:a review[J].Journal of Functional Foods,2016,25:511-522.
[39] GOH Y J,KLAENHAMMER T R.Genetic mechanisms of prebiotic oligosaccharide metabolism in probiotic microbes[J].Annual Review of Food Science and Technology,2015,6:137-156.
[40] 王璐璇,刘玥宏,朱继开,等.短链脂肪酸在疾病治疗中的研究进展[J].世界华人消化杂志,2017,25(13):1179-1186.
[41] 王敏,臧师竹,辛毅,等.小鼠肠道对壳寡糖的吸收率及吸收成分的影响[J].中国微生态学杂志,2013,25(10):1143-1144,1148.
[42] MAO B Y,GU J Y,LI D Y,et al.Effects of different doses of fructooligosaccharides (FOS) on the composition of mice fecal microbiota,especially the
Bifidobacterium composition[J].Nutrients,2018,10(8):1105.
[43] ZHONG Y,CAI D L,CAI W,et al.Protective effect of galactooligosaccharide-supplemented enteral nutrition on intestinal barrier function in rats with severe acute pancreatitis[J].Clinical Nutrition,2009,28(5):575-580.
[44] BODOGAI M,CONNELL J,KIM K,et al.Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells[J].Science Translational Medicine,2018,10(467):eaat4271.
[45] RABIEI S,HEDAYATI M,RASHIDKHANI B,et al.The effects of synbiotic supplementation on body mass index,metabolic and inflammatory biomarkers,and appetite in patients with metabolic syndrome:a triple-blind randomized controlled trial[J].Journal of Dietary Supplements,2019,16(3):294-306.
[46] DE COSSÍO L F,FOURRIER C,SAUVANT J,et al.Impact of prebiotics on metabolic and behavioral alterations in a mouse model of metabolic syndrome[J].Brain,Behavior,and Immunity,2017,64:33-49.
[47] 郑建仙.功能性低聚糖[M].北京:化学工业出版社,2004.
[48] WU R Y,ABDULLAH M,MÄÄTTÄNEN P,et al.Protein kinase C δ signaling is required for dietary prebiotic-induced strengthening of intestinal epithelial barrier function[J].Scientific Reports,2017,7:40820.
[49] 马龙.壳寡糖调节免疫力[J].家庭保健,2012(1):80-81.
