[1] 陶弘景.名医别录[M].北京:人民卫生出版社,1986.
[2] 高明焱,孙朋,杜同同,等.苦参碱衍生物的合成及其抗肿瘤活性研究进展[J].大众科技,2017,19(3):57-60.
[3] 吴波,程杏安,蒋旭红,等.苦参碱农用活性及其结构修饰研究进展[J].江苏农业科学,2019,47(8):123-129.
[4] 付奔.新型苦参碱类衍生物的设计、合成及抗肿瘤活性研究[D].硕士学位论文.上海:第二军医大学,2017.
[5] 倪晨旭.苦参碱衍生物WM130抗肝细胞癌的作用及其机制研究[D].硕士学位论文.上海:第二军医大学,2016.
[6] 邹玉明.苦参碱衍生物MASM对类风湿关节炎的治疗作用及其机制研究[D].博士学位论文.上海:中国人民解放军海军军医大学,2018.
[7] SUN K Y,YANG P Y,ZHAO R,et al.Matrine attenuates
D-galactose-induced aging-related behavior in mice via inhibition of cellular senescence and oxidative stress[J].Oxidative Medicine and Cellular Longevity,2018,2018:7108604.
[8] WU G J,ZHOU W H,ZHAO J F,et al.Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal[J].Oncotarget,2017,8(7):11621-11628.
[9] 李巨银,陈丽红,章敬旗,等.氧化苦参碱-黄芪多糖中药复方对雏鸡血清中抗氧化指标的影响[J].畜牧与兽医,2018,50(9):103-107.
[10] 卢金霞,何芳,冯峰,等.苦参碱对奶牛乳腺上皮细胞增殖、凋亡及抗氧化能力的影响[J].西北农林科技大学学报(自然科学版),2018,46(7):1-6,14.
[11] 张明发,沈雅琴.苦参碱类生物碱免疫促进作用的研究进展[J].药物评价研究,2019,42(3):579-585.
[12] ZHANG L,ZHANG H Z,ZHU Z C,et al.Matrine regulates immune functions to inhibit the proliferation of leukemic cells[J].International Journal of Clinical and Experimental Medicine,2015,8(4):5591-5600.
[13] 张瑞奎,汪超.苦参碱对大鼠乳腺癌细胞荷瘤生长及其炎性因子与免疫功能的影响[J].中国应用生理学杂志,2018,34(4):375-378.
[14] ZHANG C L,HOU H G,LI J H.Chitosan/matrine membrane preparations promote wound recovery in an
in vivo animal model of ulcer trauma[J].International Journal of Clinical and Experimental Medicine,2019,12(1):504-512.
[15] 张明发,沈雅琴.槐定碱和氧化槐定碱及13α-羟基苦参碱抗炎和免疫抑制作用的研究进展[J].抗感染药学,2018,15(6):921-925.
[16] ZHANG M L,ZHANG X J,KANG J,et al.Matrine promotes NT3 expression in CNS cells in experimental autoimmune encephalomyelitis[J].Neuroscience Letters,2017,649:100-106.
[17] LI Q,LAI Y M,WANG C B,et al.Matrine inhibits the proliferation,invasion and migration of castration-resistant prostate cancer cells through regulation of the NF-κB signaling pathway[J].Oncology Reports,2016,35(1):375-381.

[18] LI Q,HUANG H,HE Z,et al.Regulatory effects of antitumor agent matrine on FOXO and PI3K-AKT pathway in castration-resistant prostate cancer cells[J].Science China Life Sciences,2018,61(5):550-558.

[19] JIANG J H,PI J,JIN H,et al.Chinese herb medicine matrine induce apoptosis in human esophageal squamous cancer KYSE-150 cells through increasing reactive oxygen species and inhibiting mitochondrial function[J].Pathology-Research and Practice,2018,214(5):691-699.

[20] 刘冬,周伟,高晓博,等.苦参碱抑制Nrf2诱导的Annexin A4表达改善非小细胞肺癌对顺铂耐药[J].临床与病理杂志,2019,39(3):457-463.
[21] 鄂颖,尚德高,尤胜.苦参碱联合顺铂对人肝癌细胞株HepG2裸鼠移植瘤模型瘤体生长及caspase-3和survivin表达的影响[J].临床和实验医学杂志,2019,18(5):457-460.
[22] 卓新凤,姬颖华.苦参碱对人肺癌A549细胞增殖、侵袭和血管生成的抑制作用及其机制研究[J].现代药物与临床,2017,32(5):767-771.
[23] 卢迎宏,王丹,井海云.苦参碱对oxLDL诱导的血管平滑肌细胞炎症反应及增殖凋亡的影响及分子机制研究[J].中国免疫学杂志,2018,34(4):537-543.
[24] 王淑静,孙微微,张家宁,等.苦参碱、氧化苦参碱联合应用对ECV304活性及能量代谢影响[J].天然产物研究与开发,2017,29(5):741-746.
[25] ZHANG Y,CUI L,GUAN G C,et al.Matrine suppresses cardiac fibrosis by inhibiting the TGF-β/Smad pathway in experimental diabetic cardiomyopathy[J].Molecular Medicine Reports,2018,17(1):1775-1781.
[26] WANG J K,TANG Z G,ZHANG Y,et al.Matrine alleviates AGEs-induced cardiac dysfunctions by attenuating calcium overload via reducing ryanodine receptor 2 activity[J].European Journal of Pharmacology,2019,842:118-124.
[27] 徐锦龙,段宝忠,马卫成.基于数据分析苦参碱对肝脏的作用[J].浙江中西医结合杂志,2019,29(1):79-81.
[28] GAO X B,GUO S,ZHANG S,et al.Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway[J].Journal of Translational Medicine,2018,16(1):319.
[29] RAZA A,MUHAMMAD F,BASHIR S,et al.Antiviral and immune boosting activities of different medicinal plants against Newcastle disease virus in poultry[J].World's Poultry Science Journal,2015,71(3):523-532.

[30] 李时珍.本草纲目[M].北京:人民卫生出版社,1982.
[31] 刘晓丹,王惠英,李瑞和,等.HPLC法测定植物源杀螨浴剂(外用)中氧化苦参碱的含量[J].畜牧与饲料科学,2019,40(3):6-11.
[32] 雒艳萍.砂生槐种子生物碱抗包虫效应及机制研究[D].博士学位论文.兰州:兰州大学,2017.
[33] 张国超.砂生槐种子生物碱E2a联合BCG及纳米药物PLGA-Fe
3O
4-E2a的抗包虫效果评价[D].硕士学位论文.兰州:兰州大学,2018.
[34] 张明发,沈雅琴.苦参碱类生物碱抗菌药理作用的研究进展[J].抗感染药学,2018,15(3):369-374.
[35] 冷晓红,王志强,李军.苦豆子生物碱对奶牛乳房炎致病菌体外抗菌活性的研究[J].中国兽药杂志,2013,47(9):31-33.
[36] 韩欢胜,徐馨,高利.苦参碱类生物碱传递体凝胶剂对奶牛乳房炎主要病原菌的药效学研究[J].中国预防兽医学报,2017,39(4):272-276.
[37] LI P Y,LEI J J,HU G S,et al.Matrine mediates inflammatory response via gut microbiota in TNBS-induced murine colitis[J].Frontiers in Physiology,2019,10:28.
[38] FENG F,MA W W,LUO H X,et al.Effect of matrine on reducing damage to bovine mammary epithelial cells induced by Staphylococcus aureus alpha-hemolysin[J].Polish Journal of Veterinary Sciences,2018,21(2):409-413.
[39] 李治建,周凡,窦勤,等.苦参碱体外抗念珠菌活性及对白色念珠菌细胞膜生物合成的影响[J].新疆医学,2018(6):603-606.
[40] SHAO J,WANG T,YAN Y,et al.Matrine reduces yeast-to-hypha transition and resistance of a fluconazole-resistant strain of
Candida albicans[J].Journal of Applied Microbiology,2014,117(3):618-626.

[41] ZHANG M,YANG X,WANG D,et al.Antifungal activity of immunosuppressants used alone or in combination with fluconazole[J].Journal of Applied Microbiology,2019,126(5):1304-1317.

[42] BANDIERA S,PERNOT S,EL SAGHIRE H,et al.Hepatitis C virus-induced upregulation of microRNA miR-146a-5p in hepatocytes promotes viral infection and deregulates metabolic pathways associated with liver disease pathogenesis[J].Journal of Virology,2016,90(14):6387-6400.

[43] 陈曦,任浩,陈照林,等.苦参碱联合恩替卡韦抗乙型肝炎病毒感染的作用及其机制[J].现代生物医学进展,2018,18(18):3518-3520.
[44] SUN N,SUN P P,LV H P,et al.Matrine displayed antiviral activity in porcine alveolar macrophages co-infected by porcine reproductive and respiratory syndrome virus and porcine circovirus type 2[J].Scientific Reports,2016,6:24401.
[45] KOSTADINOVIC L J,PUVAC A N,POPOVIC S,et al.Botanical supplements as anti-coccidial alternatives in poultry nutrition[J].World's Poultry Science Journal,2015,71(1):27-36.

[46] 张明发,沈雅琴.苦参碱类生物碱的毒性研究进展[J].药物评价研究,2018,41(4):682-691.
[47] 杨良月.苦参碱的毒理及HPLC法测定绵羊血浆苦参碱的研究[D].硕士学位类型.呼和浩特:内蒙古农业大学,2015.